MiR-17 partly promotes hematopoietic cell expansion through augmenting HIF-1α in osteoblasts.

MiR-17 partly promotes hematopoietic cell expansion through augmenting HIF-1α in osteoblasts.

BACKGROUND: Hematopoietic stem cell (HSC) regulation is highly dependent on interactions with the marrow microenvironment, of which osteogenic cells play a crucial role. While evidence is accumulating for an important role of intrinsic miR-17 in regulating HSCs and HPCs, whether miR-17 signaling pat...

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Bibliographic Details
Main Authors: Yuxia Yang, Wei Ma, Dan Wu, Yu Huang, Hongge Li, Junhua Zou, Yanju Zhang, Meifu Feng, Jianyuan Luo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3723828?pdf=render

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