Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers—OMICs-based contributions to understanding their mechanism of action
Gastric, liver, and colorectal cancers belong to gastrointestinal (GI) cancers, one of the most threatening diseases in the world. The tonics class in Chinese medicines plays a critical role in antigastrointestinal cancer as adjuvants. However, it is a challenge to study the effects and underlying m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.986765/full |
| _version_ | 1811322758568607744 |
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| author | Zhigang Zuo Jia Jia Hongliang Li Run Shi Di Wang Ke-Wu Zeng Hong Nie Xin-Guo Wang Wen Liu Minglun Li Yibin Feng Xuan Bin Wang |
| author_facet | Zhigang Zuo Jia Jia Hongliang Li Run Shi Di Wang Ke-Wu Zeng Hong Nie Xin-Guo Wang Wen Liu Minglun Li Yibin Feng Xuan Bin Wang |
| author_sort | Zhigang Zuo |
| collection | DOAJ |
| description | Gastric, liver, and colorectal cancers belong to gastrointestinal (GI) cancers, one of the most threatening diseases in the world. The tonics class in Chinese medicines plays a critical role in antigastrointestinal cancer as adjuvants. However, it is a challenge to study the effects and underlying mechanisms of tonics due to their multiple components and multiple targets; OMICs were introduced to facilitate the investigation of the complex mixture of tonics. In this review, the online databases PubMed, ProQuest, Web of Knowledge, China National Knowledge Infrastructure (CNKI), Chongqing VIP, and Wanfang were retrieved from 1 January 2011 to 31 May 2022, in an aim to summarize and discuss the research progress of the effects and, especially, the underlying mechanisms of tonics for antigastrointestinal cancers via OMICs. The results showed that through the combination of OMICs and other technologies, tonics have been used for gastrointestinal cancer by targeting cancer hallmarks, enhancing body resistance to carcinogenesis, enhancing therapeutic effects, and/or decreasing side effects. In conclusion, tonics may play a promising role in gastric, liver, and colorectal cancers as adjuvants and can be well investigated via the combination of OMICs and other technologies, which deserves further study. |
| first_indexed | 2024-04-13T13:41:47Z |
| format | Article |
| id | doaj.art-da73ef92e4824c8b87ecc792ba826bff |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T13:41:47Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-da73ef92e4824c8b87ecc792ba826bff2022-12-22T02:44:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.986765986765Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers—OMICs-based contributions to understanding their mechanism of actionZhigang Zuo0Jia Jia1Hongliang Li2Run Shi3Di Wang4Ke-Wu Zeng5Hong Nie6Xin-Guo Wang7Wen Liu8Minglun Li9Yibin Feng10Xuan Bin Wang11Laboratory of Chinese Herbal Pharmacology, Department of Pharmacy, Renmin Hospital, Biomedical Research Institute, School of Pharmaceutical Sciences and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, ChinaLaboratory of Chinese Herbal Pharmacology, Department of Pharmacy, Renmin Hospital, Biomedical Research Institute, School of Pharmaceutical Sciences and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, ChinaLaboratory of Chinese Herbal Pharmacology, Department of Pharmacy, Renmin Hospital, Biomedical Research Institute, School of Pharmaceutical Sciences and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, ChinaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, ChinaInternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, ChinaSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, ChinaSchool of Pharmacy, Guizhou Medical University, Guiyang, ChinaDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, GermanySchool of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, ChinaLaboratory of Chinese Herbal Pharmacology, Department of Pharmacy, Renmin Hospital, Biomedical Research Institute, School of Pharmaceutical Sciences and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, ChinaGastric, liver, and colorectal cancers belong to gastrointestinal (GI) cancers, one of the most threatening diseases in the world. The tonics class in Chinese medicines plays a critical role in antigastrointestinal cancer as adjuvants. However, it is a challenge to study the effects and underlying mechanisms of tonics due to their multiple components and multiple targets; OMICs were introduced to facilitate the investigation of the complex mixture of tonics. In this review, the online databases PubMed, ProQuest, Web of Knowledge, China National Knowledge Infrastructure (CNKI), Chongqing VIP, and Wanfang were retrieved from 1 January 2011 to 31 May 2022, in an aim to summarize and discuss the research progress of the effects and, especially, the underlying mechanisms of tonics for antigastrointestinal cancers via OMICs. The results showed that through the combination of OMICs and other technologies, tonics have been used for gastrointestinal cancer by targeting cancer hallmarks, enhancing body resistance to carcinogenesis, enhancing therapeutic effects, and/or decreasing side effects. In conclusion, tonics may play a promising role in gastric, liver, and colorectal cancers as adjuvants and can be well investigated via the combination of OMICs and other technologies, which deserves further study.https://www.frontiersin.org/articles/10.3389/fphar.2022.986765/fullChinese medicinestonicsgastrointestinal cancerOMICshallmark |
| spellingShingle | Zhigang Zuo Jia Jia Hongliang Li Run Shi Di Wang Ke-Wu Zeng Hong Nie Xin-Guo Wang Wen Liu Minglun Li Yibin Feng Xuan Bin Wang Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers—OMICs-based contributions to understanding their mechanism of action Frontiers in Pharmacology Chinese medicines tonics gastrointestinal cancer OMICs hallmark |
| title | Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers—OMICs-based contributions to understanding their mechanism of action |
| title_full | Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers—OMICs-based contributions to understanding their mechanism of action |
| title_fullStr | Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers—OMICs-based contributions to understanding their mechanism of action |
| title_full_unstemmed | Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers—OMICs-based contributions to understanding their mechanism of action |
| title_short | Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers—OMICs-based contributions to understanding their mechanism of action |
| title_sort | adjuvant effects of chinese medicinal tonics on gastric liver and colorectal cancers omics based contributions to understanding their mechanism of action |
| topic | Chinese medicines tonics gastrointestinal cancer OMICs hallmark |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.986765/full |
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