Successful simultaneous targeting of IgE and IL-5 in a severe asthmatic patient selected for lung transplantation
We report a case of severe uncontrolled allergic and eosinophilic asthma in which omalizumab had led to a fast remission. After 18 months, mepolizumab was added to omalizumab because of increased blood eosinophils and a deterioration of asthma control. Asthma was then under control for the next 18 m...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | World Allergy Organization Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S193945512200045X |
| _version_ | 1797999919963832320 |
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| author | Karl-Christian Bergmann, PhD, MD Jörg-Wilhelm Oestmann, MD Jean Bousquet, MD, PhD Torsten Zuberbier, PhD, MD |
| author_facet | Karl-Christian Bergmann, PhD, MD Jörg-Wilhelm Oestmann, MD Jean Bousquet, MD, PhD Torsten Zuberbier, PhD, MD |
| author_sort | Karl-Christian Bergmann, PhD, MD |
| collection | DOAJ |
| description | We report a case of severe uncontrolled allergic and eosinophilic asthma in which omalizumab had led to a fast remission. After 18 months, mepolizumab was added to omalizumab because of increased blood eosinophils and a deterioration of asthma control. Asthma was then under control for the next 18 months. Discontinuation of mepolizumab in the ensuing 6 months led to a decrease in asthma control and an increased eosinophilia. The introduction of benralizumab resulted in an immediate increase of lung function, asthma control test (ACT), and symptom relief. Before the introduction of biologics, the patient was on the list for transplantation due to respiratory insufficiency. High-resolution CT scans before and after biologic therapy demonstrated a reduction of bronchial wall thickening and mucous plugging as well as an increase in bronchial caliber. The patient did therefore not need a transplant. We conclude that the dual use of biologics may be efficient in some cases of severe asthma. |
| first_indexed | 2024-04-11T11:12:15Z |
| format | Article |
| id | doaj.art-da7404f7375747f7a5914c23add48830 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-04-11T11:12:15Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-da7404f7375747f7a5914c23add488302022-12-22T04:27:26ZengElsevierWorld Allergy Organization Journal1939-45512022-08-01158100669Successful simultaneous targeting of IgE and IL-5 in a severe asthmatic patient selected for lung transplantationKarl-Christian Bergmann, PhD, MD0Jörg-Wilhelm Oestmann, MD1Jean Bousquet, MD, PhD2Torsten Zuberbier, PhD, MD3Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Allergology and Immunology, Berlin, Germany; Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Corresponding author. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Allergology and Immunology, Berlin, GermanyCharité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, GermanyInstitute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; University of Montpellier, Montpellier, France; Centre Hospitalier Universitaire de Montpellier (CHU), Montpellier, France; Contre les Maladies Chroniques pour un VIeillissement Actif (MACVIA) en France, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France; Department of Dermatology and Allergy Comprehensive Allergy Center Berlin Institute of Health, Berlin, GermanyFraunhofer Institute for Translational Medicine and Pharmacology ITMP Allergology and Immunology, Berlin, Germany; Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyWe report a case of severe uncontrolled allergic and eosinophilic asthma in which omalizumab had led to a fast remission. After 18 months, mepolizumab was added to omalizumab because of increased blood eosinophils and a deterioration of asthma control. Asthma was then under control for the next 18 months. Discontinuation of mepolizumab in the ensuing 6 months led to a decrease in asthma control and an increased eosinophilia. The introduction of benralizumab resulted in an immediate increase of lung function, asthma control test (ACT), and symptom relief. Before the introduction of biologics, the patient was on the list for transplantation due to respiratory insufficiency. High-resolution CT scans before and after biologic therapy demonstrated a reduction of bronchial wall thickening and mucous plugging as well as an increase in bronchial caliber. The patient did therefore not need a transplant. We conclude that the dual use of biologics may be efficient in some cases of severe asthma.http://www.sciencedirect.com/science/article/pii/S193945512200045XOmalizumabMepolizumabBenralizumabSimultaneous use of biologicsSevere allergic and eosinophilic asthma |
| spellingShingle | Karl-Christian Bergmann, PhD, MD Jörg-Wilhelm Oestmann, MD Jean Bousquet, MD, PhD Torsten Zuberbier, PhD, MD Successful simultaneous targeting of IgE and IL-5 in a severe asthmatic patient selected for lung transplantation World Allergy Organization Journal Omalizumab Mepolizumab Benralizumab Simultaneous use of biologics Severe allergic and eosinophilic asthma |
| title | Successful simultaneous targeting of IgE and IL-5 in a severe asthmatic patient selected for lung transplantation |
| title_full | Successful simultaneous targeting of IgE and IL-5 in a severe asthmatic patient selected for lung transplantation |
| title_fullStr | Successful simultaneous targeting of IgE and IL-5 in a severe asthmatic patient selected for lung transplantation |
| title_full_unstemmed | Successful simultaneous targeting of IgE and IL-5 in a severe asthmatic patient selected for lung transplantation |
| title_short | Successful simultaneous targeting of IgE and IL-5 in a severe asthmatic patient selected for lung transplantation |
| title_sort | successful simultaneous targeting of ige and il 5 in a severe asthmatic patient selected for lung transplantation |
| topic | Omalizumab Mepolizumab Benralizumab Simultaneous use of biologics Severe allergic and eosinophilic asthma |
| url | http://www.sciencedirect.com/science/article/pii/S193945512200045X |
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