Non-adherence to antiretroviral therapy in Yaounde: Prevalence, determinants and the concordance of two screening criteria
Summary: Purpose: To assess the prevalence and determinants of non-adherence to antiretroviral therapy (ART) as well as the concordance of two screening criteria in a major center for human immunodeficiency virus (HIV) treatment in Yaounde, Cameroon. Methods: In 2011, we conducted a cross-sectional...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-08-01
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| Series: | Journal of Infection and Public Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187603411300035X |
| _version_ | 1818038440402354176 |
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| author | Eric Walter Pefura-Yone Emmanuel Soh André Pascal Kengne Adamou Dodo Balkissou Christopher Kuaban |
| author_facet | Eric Walter Pefura-Yone Emmanuel Soh André Pascal Kengne Adamou Dodo Balkissou Christopher Kuaban |
| author_sort | Eric Walter Pefura-Yone |
| collection | DOAJ |
| description | Summary: Purpose: To assess the prevalence and determinants of non-adherence to antiretroviral therapy (ART) as well as the concordance of two screening criteria in a major center for human immunodeficiency virus (HIV) treatment in Yaounde, Cameroon. Methods: In 2011, we conducted a cross-sectional study involving a random sample of 889 adults (age > 18 years, 67.9% women) infected with HIV who were receiving chronic care at the Yaounde Jamot Hospital. Adherence was assessed via self-administered questionnaires using the Community Programs for Clinical Research on AIDS (CPCRA) index and the Center for Adherence Support Evaluation (CASE) index. Results: The prevalence of non-adherence to ART was 22.5% based on the CPCRA index and 34.9% based on the CASE index, with a low agreement between the two indexes [kappa = 0.37 (95% confidence interval 0.31–0.44)]. Independent determinants of CPCRA-diagnosed non-adherence were as follows: being a remunerated employee [odds ratio (95% confidence interval): 1.61 (1.14–2.28)], Pentecostal Christianity [2.18 (1.25–3.80)], alcohol consumption [1.65 (1.16–2.34)] and non-adherence to cotrimoxazole prophylaxis [5.73 (3.92–8.38)]. The equivalents for CASE-diagnosed non-adherence were [1.59 (1.19–2.12)], [1.83 (1.36–2.47)], [1.70 (1.27–2.28)], respectively, in addition to association with changes to the ART regimen [1.61 (1.17–2.20)]. Conclusions: Non-adherence to ART remains high in this population. The careful evaluation of patients for the presence of determinants of non-adherence identified in this study may aid ART optimization. Keywords: Antiretroviral therapy, Adherence, HIV infection, Cameroon |
| first_indexed | 2024-12-10T07:42:46Z |
| format | Article |
| id | doaj.art-da743768e25c4d2e9143f3fac5f41fb7 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-10T07:42:46Z |
| publishDate | 2013-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-da743768e25c4d2e9143f3fac5f41fb72022-12-22T01:57:17ZengElsevierJournal of Infection and Public Health1876-03412013-08-0164307315Non-adherence to antiretroviral therapy in Yaounde: Prevalence, determinants and the concordance of two screening criteriaEric Walter Pefura-Yone0Emmanuel Soh1André Pascal Kengne2Adamou Dodo Balkissou3Christopher Kuaban4Department of Internal Medicine and Subspecialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon; Pneumology Service, Yaounde Jamot Hospital, Cameroon; Corresponding author at: Yaounde Jamot's Hospital, PO Box 4021-Yaounde, Cameroon. Tel.: +237 9653972; fax: +237 22203165.Pneumology Service, Yaounde Jamot Hospital, CameroonSouth African Medical Research Council & University of Cape Town, Cape Town, South AfricaDepartment of Internal Medicine and Subspecialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, CameroonDepartment of Internal Medicine and Subspecialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon; Pneumology Service, Yaounde Jamot Hospital, CameroonSummary: Purpose: To assess the prevalence and determinants of non-adherence to antiretroviral therapy (ART) as well as the concordance of two screening criteria in a major center for human immunodeficiency virus (HIV) treatment in Yaounde, Cameroon. Methods: In 2011, we conducted a cross-sectional study involving a random sample of 889 adults (age > 18 years, 67.9% women) infected with HIV who were receiving chronic care at the Yaounde Jamot Hospital. Adherence was assessed via self-administered questionnaires using the Community Programs for Clinical Research on AIDS (CPCRA) index and the Center for Adherence Support Evaluation (CASE) index. Results: The prevalence of non-adherence to ART was 22.5% based on the CPCRA index and 34.9% based on the CASE index, with a low agreement between the two indexes [kappa = 0.37 (95% confidence interval 0.31–0.44)]. Independent determinants of CPCRA-diagnosed non-adherence were as follows: being a remunerated employee [odds ratio (95% confidence interval): 1.61 (1.14–2.28)], Pentecostal Christianity [2.18 (1.25–3.80)], alcohol consumption [1.65 (1.16–2.34)] and non-adherence to cotrimoxazole prophylaxis [5.73 (3.92–8.38)]. The equivalents for CASE-diagnosed non-adherence were [1.59 (1.19–2.12)], [1.83 (1.36–2.47)], [1.70 (1.27–2.28)], respectively, in addition to association with changes to the ART regimen [1.61 (1.17–2.20)]. Conclusions: Non-adherence to ART remains high in this population. The careful evaluation of patients for the presence of determinants of non-adherence identified in this study may aid ART optimization. Keywords: Antiretroviral therapy, Adherence, HIV infection, Cameroonhttp://www.sciencedirect.com/science/article/pii/S187603411300035X |
| spellingShingle | Eric Walter Pefura-Yone Emmanuel Soh André Pascal Kengne Adamou Dodo Balkissou Christopher Kuaban Non-adherence to antiretroviral therapy in Yaounde: Prevalence, determinants and the concordance of two screening criteria Journal of Infection and Public Health |
| title | Non-adherence to antiretroviral therapy in Yaounde: Prevalence, determinants and the concordance of two screening criteria |
| title_full | Non-adherence to antiretroviral therapy in Yaounde: Prevalence, determinants and the concordance of two screening criteria |
| title_fullStr | Non-adherence to antiretroviral therapy in Yaounde: Prevalence, determinants and the concordance of two screening criteria |
| title_full_unstemmed | Non-adherence to antiretroviral therapy in Yaounde: Prevalence, determinants and the concordance of two screening criteria |
| title_short | Non-adherence to antiretroviral therapy in Yaounde: Prevalence, determinants and the concordance of two screening criteria |
| title_sort | non adherence to antiretroviral therapy in yaounde prevalence determinants and the concordance of two screening criteria |
| url | http://www.sciencedirect.com/science/article/pii/S187603411300035X |
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