Hexachlorocyclotriphosphazene (HCCP)-Mediated Direct Formation of Thioethers and Ethers from Quinazolin-4(3H)-ones

Hexachlorocyclotriphosphazene (HCCP)-Mediated Direct Formation of Thioethers and Ethers from Quinazolin-4(3H)-ones

A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline de...

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Bibliographic Details
Main Authors: Weimin Mo, Nan Sun, Xinquan Hu, Ming Guo, Zhenlu Shen, Lili Sheng, Xiaochu Zhang, Baoxiang Hu
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Molecules
Subjects:
quinazolin-4(3H)-ones
hexachlorocyclotriphosphazene
4-arylthioquinazolines
4-aryloxyquinazolines
4-alkoxyquinazolines
Online Access:http://www.mdpi.com/1420-3049/18/5/5580
Description
Summary:A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-aryloxyquinazoline and 4-alkoxyquinazoline derivatives using phenols and sodium alkoxides as the nucleophiles.
ISSN:1420-3049

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