Painful peripheral neuropathy
Painful peripheral neuropathy (PPN) is characterized by neuropathic pain (NP), which is accompanied by dysfunction of motor, sensory and autonomic nervous system. It always involves small nerve fibers, including A δ and C fibers. PPN can be classified into two types according to etiology: hereditary...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2013-09-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/798 |
| _version_ | 1819074820533387264 |
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| author | Bo SUN Xu-sheng HUANG |
| author_facet | Bo SUN Xu-sheng HUANG |
| author_sort | Bo SUN |
| collection | DOAJ |
| description | Painful peripheral neuropathy (PPN) is characterized by neuropathic pain (NP), which is accompanied by dysfunction of motor, sensory and autonomic nervous system. It always involves small nerve fibers, including A δ and C fibers. PPN can be classified into two types according to etiology: hereditary and acquired. Pain of PPN can manifest as spontaneous pain and stimulus-evoked pain (allodynia, hyperalgesia and hyperpathia). The manifestation of typical cases is length-dependent, which firstly involves the feet, and then progresses proximally and to the hands, presenting a glove-stock pattern. PPN can be either an isolated disease entity or part of other diseases. The former indicates idiopathic small fiber neuropathy (SFN), while the latter contains various diseases involving peripheral nerve fibers, including systemic diseases such as diabetes mellitus and peripheral neuropathy with other causes. The accessory examinations of PPN include quantitative sensory testing (QST), intraepidermal nerve fiber density (IENFD), sympathetic skin response (SSR), etc. Among them, IENFD is the "golden standard" for SFN. The major therapeutic methods are to control primary diseases and relieve pain. Medications alleviating neuropathic pain consist of carbamazepine, pregabalin, gabapentin and amitriptyline, etc. <br /> |
| first_indexed | 2024-12-21T18:15:35Z |
| format | Article |
| id | doaj.art-da75429985824bcab9ad230d303d22d1 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-21T18:15:35Z |
| publishDate | 2013-09-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-da75429985824bcab9ad230d303d22d12022-12-21T18:54:41ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312013-09-01139755759797Painful peripheral neuropathyBo SUNXu-sheng HUANGPainful peripheral neuropathy (PPN) is characterized by neuropathic pain (NP), which is accompanied by dysfunction of motor, sensory and autonomic nervous system. It always involves small nerve fibers, including A δ and C fibers. PPN can be classified into two types according to etiology: hereditary and acquired. Pain of PPN can manifest as spontaneous pain and stimulus-evoked pain (allodynia, hyperalgesia and hyperpathia). The manifestation of typical cases is length-dependent, which firstly involves the feet, and then progresses proximally and to the hands, presenting a glove-stock pattern. PPN can be either an isolated disease entity or part of other diseases. The former indicates idiopathic small fiber neuropathy (SFN), while the latter contains various diseases involving peripheral nerve fibers, including systemic diseases such as diabetes mellitus and peripheral neuropathy with other causes. The accessory examinations of PPN include quantitative sensory testing (QST), intraepidermal nerve fiber density (IENFD), sympathetic skin response (SSR), etc. Among them, IENFD is the "golden standard" for SFN. The major therapeutic methods are to control primary diseases and relieve pain. Medications alleviating neuropathic pain consist of carbamazepine, pregabalin, gabapentin and amitriptyline, etc. <br />http://www.cjcnn.org/index.php/cjcnn/article/view/798Peripheral nervous system diseasesNeuralgiaPain measurementDrug therapyReview |
| spellingShingle | Bo SUN Xu-sheng HUANG Painful peripheral neuropathy Chinese Journal of Contemporary Neurology and Neurosurgery Peripheral nervous system diseases Neuralgia Pain measurement Drug therapy Review |
| title | Painful peripheral neuropathy |
| title_full | Painful peripheral neuropathy |
| title_fullStr | Painful peripheral neuropathy |
| title_full_unstemmed | Painful peripheral neuropathy |
| title_short | Painful peripheral neuropathy |
| title_sort | painful peripheral neuropathy |
| topic | Peripheral nervous system diseases Neuralgia Pain measurement Drug therapy Review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/798 |
| work_keys_str_mv | AT bosun painfulperipheralneuropathy AT xushenghuang painfulperipheralneuropathy |