Transcriptional state dynamics lead to heterogeneity and adaptive tumor evolution in urothelial bladder carcinoma

Transcriptional state dynamics lead to heterogeneity and adaptive tumor evolution in urothelial bladder carcinoma

Abstract Intra-tumor heterogeneity contributes to treatment failure and poor survival in urothelial bladder carcinoma (UBC). Analyzing transcriptome from a UBC cohort, we report that intra-tumor transcriptomic heterogeneity indicates co-existence of tumor cells in epithelial and mesenchymal-like tra...

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Bibliographic Details
Main Authors: Antara Biswas, Sarthak Sahoo, Gregory M. Riedlinger, Saum Ghodoussipour, Mohit K. Jolly, Subhajyoti De
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05668-3

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https://doi.org/10.1038/s42003-023-05668-3

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