Comprehensive evaluation of solvent in dispersive liquid-liquid microextraction for determination of itraconazole and hydroxy itraconazole by high performance liquid chromatography with fluorescence detection
This paper aims to propose a multicriteria decision analysis (MCDA) method to evaluate and select solvent in a dispersive liquid-liquid microextraction (DLLME) approach. The DLLME is applied to the determination of itraconazole and hydroxy itraconazole in plasma by high performance liquid chromatogr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535223000266 |
| _version_ | 1811159992352374784 |
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| author | Zhixiang Cheng Jian Liang Yanan Hu Qianzhou Lv Xiaoyu Li Xiong Shen |
| author_facet | Zhixiang Cheng Jian Liang Yanan Hu Qianzhou Lv Xiaoyu Li Xiong Shen |
| author_sort | Zhixiang Cheng |
| collection | DOAJ |
| description | This paper aims to propose a multicriteria decision analysis (MCDA) method to evaluate and select solvent in a dispersive liquid-liquid microextraction (DLLME) approach. The DLLME is applied to the determination of itraconazole and hydroxy itraconazole in plasma by high performance liquid chromatography with fluorescence detection (HPLC-FLD). To achieve this goal, extraction efficiency, chromatographic resolution, and greenness of solvent were identified as the three indicators in MCDA. Then, Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) was employed to evaluate and select the solvent. Weight assignment was set up by integrating the subjective scoring from experienced analysts and the objective approach using Shannon’s entropy weight method. Under chosen parameters (extraction solvent: 1-decanol 40 μL, dispersing solvent: methanol 400 μL), the method was validated satisfactorily and applied successfully to the analysis of itraconazole and hydroxy itraconazole in real human plasma samples. The results show that the comprehensive weighted TOPSIS analysis is a promising tool to choose experimental conditions toward an integrative goal. It can provide analysts with a decision making reference to maintain a balance between the analytical performance and eco-friendliness. |
| first_indexed | 2024-04-10T05:50:08Z |
| format | Article |
| id | doaj.art-da769f38605742d0b8f2d40dcbe44393 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-10T05:50:08Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-da769f38605742d0b8f2d40dcbe443932023-03-05T04:23:46ZengElsevierArabian Journal of Chemistry1878-53522023-04-01164104565Comprehensive evaluation of solvent in dispersive liquid-liquid microextraction for determination of itraconazole and hydroxy itraconazole by high performance liquid chromatography with fluorescence detectionZhixiang Cheng0Jian Liang1Yanan Hu2Qianzhou Lv3Xiaoyu Li4Xiong Shen5Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Corresponding author.This paper aims to propose a multicriteria decision analysis (MCDA) method to evaluate and select solvent in a dispersive liquid-liquid microextraction (DLLME) approach. The DLLME is applied to the determination of itraconazole and hydroxy itraconazole in plasma by high performance liquid chromatography with fluorescence detection (HPLC-FLD). To achieve this goal, extraction efficiency, chromatographic resolution, and greenness of solvent were identified as the three indicators in MCDA. Then, Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) was employed to evaluate and select the solvent. Weight assignment was set up by integrating the subjective scoring from experienced analysts and the objective approach using Shannon’s entropy weight method. Under chosen parameters (extraction solvent: 1-decanol 40 μL, dispersing solvent: methanol 400 μL), the method was validated satisfactorily and applied successfully to the analysis of itraconazole and hydroxy itraconazole in real human plasma samples. The results show that the comprehensive weighted TOPSIS analysis is a promising tool to choose experimental conditions toward an integrative goal. It can provide analysts with a decision making reference to maintain a balance between the analytical performance and eco-friendliness.http://www.sciencedirect.com/science/article/pii/S1878535223000266Technique for order of preference by similarity to ideal solution (TOPSIS)EntropyMulticriteria decision analysisDispersive liquid-liquid microextractionGreen analytical chemistry |
| spellingShingle | Zhixiang Cheng Jian Liang Yanan Hu Qianzhou Lv Xiaoyu Li Xiong Shen Comprehensive evaluation of solvent in dispersive liquid-liquid microextraction for determination of itraconazole and hydroxy itraconazole by high performance liquid chromatography with fluorescence detection Arabian Journal of Chemistry Technique for order of preference by similarity to ideal solution (TOPSIS) Entropy Multicriteria decision analysis Dispersive liquid-liquid microextraction Green analytical chemistry |
| title | Comprehensive evaluation of solvent in dispersive liquid-liquid microextraction for determination of itraconazole and hydroxy itraconazole by high performance liquid chromatography with fluorescence detection |
| title_full | Comprehensive evaluation of solvent in dispersive liquid-liquid microextraction for determination of itraconazole and hydroxy itraconazole by high performance liquid chromatography with fluorescence detection |
| title_fullStr | Comprehensive evaluation of solvent in dispersive liquid-liquid microextraction for determination of itraconazole and hydroxy itraconazole by high performance liquid chromatography with fluorescence detection |
| title_full_unstemmed | Comprehensive evaluation of solvent in dispersive liquid-liquid microextraction for determination of itraconazole and hydroxy itraconazole by high performance liquid chromatography with fluorescence detection |
| title_short | Comprehensive evaluation of solvent in dispersive liquid-liquid microextraction for determination of itraconazole and hydroxy itraconazole by high performance liquid chromatography with fluorescence detection |
| title_sort | comprehensive evaluation of solvent in dispersive liquid liquid microextraction for determination of itraconazole and hydroxy itraconazole by high performance liquid chromatography with fluorescence detection |
| topic | Technique for order of preference by similarity to ideal solution (TOPSIS) Entropy Multicriteria decision analysis Dispersive liquid-liquid microextraction Green analytical chemistry |
| url | http://www.sciencedirect.com/science/article/pii/S1878535223000266 |
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