Holmium-166 Transarterial Radioembolization for the Treatment of Intrahepatic Cholangiocarcinoma: A Case Series
Background: Transarterial radioembolization (TARE) is used to treat primary and secondary malignancies in the liver that are not amenable to curative resection. Accumulating evidence demonstrates the efficacy and safety of TARE with yttrium-90 (<sup>90</sup>Y), which is the most widely u...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/19/4791 |
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| author | Sim Vermeulen Katrien De Keukeleire Nicole Dorny Isabelle Colle Bert Van Den Bossche Victor Nuttens Dirk Ooms Pieter De Bondt Olivier De Winter |
| author_facet | Sim Vermeulen Katrien De Keukeleire Nicole Dorny Isabelle Colle Bert Van Den Bossche Victor Nuttens Dirk Ooms Pieter De Bondt Olivier De Winter |
| author_sort | Sim Vermeulen |
| collection | DOAJ |
| description | Background: Transarterial radioembolization (TARE) is used to treat primary and secondary malignancies in the liver that are not amenable to curative resection. Accumulating evidence demonstrates the efficacy and safety of TARE with yttrium-90 (<sup>90</sup>Y), which is the most widely used radionuclide for TARE, and later with holmium-166 (<sup>166</sup>Ho) for various indications. However, the safety and efficacy of <sup>166</sup>Ho TARE in patients with intrahepatic cholangiocarcinoma (ICC) remains to be studied. Methods: This was a retrospective case series study of seven consecutive patients with ICC who were treated with <sup>166-</sup>Ho-TARE in our center. We recorded the clinical parameters and outcomes of the TARE procedures, the tumor response according to mRECIST, subsequent treatments, and adverse events. Results: Three out of the seven patients had a partial or complete response. Two patients had stable disease after the first TARE procedure, and two of the patients (one with a complete response, and one with stable disease) were alive at the time of analysis. No serious adverse events related to the procedure were recorded. Conclusions: This is the first case series reporting the safety and tumor response outcomes of <sup>166</sup>Ho-TARE for ICC. The treatment demonstrated its versatility, allowing for reaching a high tumor dose, which is important for improving tumor response and treating patients in a palliative setting, where safety and the preservation of quality of life are paramount. |
| first_indexed | 2024-03-10T21:48:04Z |
| format | Article |
| id | doaj.art-da792a899d274b3a9c8ec4368789d9b2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T21:48:04Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-da792a899d274b3a9c8ec4368789d9b22023-11-19T14:10:37ZengMDPI AGCancers2072-66942023-09-011519479110.3390/cancers15194791Holmium-166 Transarterial Radioembolization for the Treatment of Intrahepatic Cholangiocarcinoma: A Case SeriesSim Vermeulen0Katrien De Keukeleire1Nicole Dorny2Isabelle Colle3Bert Van Den Bossche4Victor Nuttens5Dirk Ooms6Pieter De Bondt7Olivier De Winter8Nuclear Medicine Department, A.S.Z. Aalst, 9300 Aalst, BelgiumInterventional Radiology Department, A.S.Z. Aalst, 9300 Aalst, BelgiumNuclear Medicine Department, A.S.Z. Aalst, 9300 Aalst, BelgiumGastroenterology Department, A.S.Z. Aalst, 9300 Aalst, BelgiumAbdominal Surgery Department, A.S.Z. Aalst, 9300 Aalst, BelgiumNuclear Medicine Department, A.S.Z. Aalst, 9300 Aalst, BelgiumNuclear Medicine Department, A.S.Z. Aalst, 9300 Aalst, BelgiumNuclear Medicine Department, A.S.Z. Aalst, 9300 Aalst, BelgiumNuclear Medicine Department, A.S.Z. Aalst, 9300 Aalst, BelgiumBackground: Transarterial radioembolization (TARE) is used to treat primary and secondary malignancies in the liver that are not amenable to curative resection. Accumulating evidence demonstrates the efficacy and safety of TARE with yttrium-90 (<sup>90</sup>Y), which is the most widely used radionuclide for TARE, and later with holmium-166 (<sup>166</sup>Ho) for various indications. However, the safety and efficacy of <sup>166</sup>Ho TARE in patients with intrahepatic cholangiocarcinoma (ICC) remains to be studied. Methods: This was a retrospective case series study of seven consecutive patients with ICC who were treated with <sup>166-</sup>Ho-TARE in our center. We recorded the clinical parameters and outcomes of the TARE procedures, the tumor response according to mRECIST, subsequent treatments, and adverse events. Results: Three out of the seven patients had a partial or complete response. Two patients had stable disease after the first TARE procedure, and two of the patients (one with a complete response, and one with stable disease) were alive at the time of analysis. No serious adverse events related to the procedure were recorded. Conclusions: This is the first case series reporting the safety and tumor response outcomes of <sup>166</sup>Ho-TARE for ICC. The treatment demonstrated its versatility, allowing for reaching a high tumor dose, which is important for improving tumor response and treating patients in a palliative setting, where safety and the preservation of quality of life are paramount.https://www.mdpi.com/2072-6694/15/19/4791intrahepatic cholangiocarcinomatransarterial radioembolization (TARE)selective internal radiation therapy (SIRT)holmiumsafety |
| spellingShingle | Sim Vermeulen Katrien De Keukeleire Nicole Dorny Isabelle Colle Bert Van Den Bossche Victor Nuttens Dirk Ooms Pieter De Bondt Olivier De Winter Holmium-166 Transarterial Radioembolization for the Treatment of Intrahepatic Cholangiocarcinoma: A Case Series Cancers intrahepatic cholangiocarcinoma transarterial radioembolization (TARE) selective internal radiation therapy (SIRT) holmium safety |
| title | Holmium-166 Transarterial Radioembolization for the Treatment of Intrahepatic Cholangiocarcinoma: A Case Series |
| title_full | Holmium-166 Transarterial Radioembolization for the Treatment of Intrahepatic Cholangiocarcinoma: A Case Series |
| title_fullStr | Holmium-166 Transarterial Radioembolization for the Treatment of Intrahepatic Cholangiocarcinoma: A Case Series |
| title_full_unstemmed | Holmium-166 Transarterial Radioembolization for the Treatment of Intrahepatic Cholangiocarcinoma: A Case Series |
| title_short | Holmium-166 Transarterial Radioembolization for the Treatment of Intrahepatic Cholangiocarcinoma: A Case Series |
| title_sort | holmium 166 transarterial radioembolization for the treatment of intrahepatic cholangiocarcinoma a case series |
| topic | intrahepatic cholangiocarcinoma transarterial radioembolization (TARE) selective internal radiation therapy (SIRT) holmium safety |
| url | https://www.mdpi.com/2072-6694/15/19/4791 |
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