Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a powerful nuclear transcription factor that coordinates an antioxidant cytoprotector system complex stimulated by the increase in inoxidative stress (OS). In the present manuscript, we conduct a review on the evidence that shows the effect diffe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/6/196 |
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| author | Nancy Vargas-Mendoza Ángel Morales-González Eduardo Osiris Madrigal-Santillán Eduardo Madrigal-Bujaidar Isela Álvarez-González Luis Fernando García-Melo Liliana Anguiano-Robledo Tomás Fregoso-Aguilar José A. Morales-Gonzalez |
| author_facet | Nancy Vargas-Mendoza Ángel Morales-González Eduardo Osiris Madrigal-Santillán Eduardo Madrigal-Bujaidar Isela Álvarez-González Luis Fernando García-Melo Liliana Anguiano-Robledo Tomás Fregoso-Aguilar José A. Morales-Gonzalez |
| author_sort | Nancy Vargas-Mendoza |
| collection | DOAJ |
| description | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a powerful nuclear transcription factor that coordinates an antioxidant cytoprotector system complex stimulated by the increase in inoxidative stress (OS). In the present manuscript, we conduct a review on the evidence that shows the effect different modalities of physical exercise exert on the antioxidant metabolic response directed by Nrf2. During physical exercise, the reactive oxygen species (ROS) are increased; therefore, if the endogenous and exogenous antioxidant defenses are unable to control the elevation of ROS, the resulting OS triggers the activation of the transcriptional factor Nrf2 to induce the antioxidant response. On a molecular basis related to physical exercise, hormesis maintenance (exercise preconditioning) and adaptative changes in training are supported by a growing body of evidence, which is important for detailing the health benefits that involve greater resistance to environmental aggressions, better tolerance to constant changes, and increasing the regenerative capacity of the cells in such a way that it may be used as a tool to support the prevention or treatment of diseases. This may have clinical implications for future investigations regarding physical exercise in terms of understanding adaptations in high-performance athletes but also as a therapeutic model in several diseases. |
| first_indexed | 2024-03-12T19:30:02Z |
| format | Article |
| id | doaj.art-da79f1a17a784a56b2d276aae87e62e3 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T19:30:02Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-da79f1a17a784a56b2d276aae87e62e32023-08-02T04:40:00ZengMDPI AGAntioxidants2076-39212019-06-018619610.3390/antiox8060196antiox8060196Antioxidant and Adaptative Response Mediated by Nrf2 during Physical ExerciseNancy Vargas-Mendoza0Ángel Morales-González1Eduardo Osiris Madrigal-Santillán2Eduardo Madrigal-Bujaidar3Isela Álvarez-González4Luis Fernando García-Melo5Liliana Anguiano-Robledo6Tomás Fregoso-Aguilar7José A. Morales-Gonzalez8México Laboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón S/N, Col. Casco de Santo Tomás, CP 11340 Alcaldía Miguel Hidalgo, MexicoEscuela Superior de Cómputo, Instituto Politécnico Nacional, Av. Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal, Unidad Profesional Adolfo López Mateos, CP 07738 Ciudad de México, MexicoMéxico Laboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón S/N, Col. Casco de Santo Tomás, CP 11340 Alcaldía Miguel Hidalgo, MexicoEscuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, “Unidad Profesional A. López Mateos”. Av. WilfridoMassieu. Col., Lindavista, 07738 Ciudad de México, MexicoEscuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, “Unidad Profesional A. López Mateos”. Av. WilfridoMassieu. Col., Lindavista, 07738 Ciudad de México, MexicoEscuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, “Unidad Profesional A. López Mateos”. Av. WilfridoMassieu. Col., Lindavista, 07738 Ciudad de México, MexicoLaboratorio de Farmacología Molecular, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina-Instituto Politécnico Nacional, 11340 Ciudad de México, MexicoDepartamento de Fisiología, Laboratorio de Hormonas y Conducta, ENCB Campus Zacatenco, Instituto Politécnico Nacional, 07700 Ciudad de México, MexicoMéxico Laboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón S/N, Col. Casco de Santo Tomás, CP 11340 Alcaldía Miguel Hidalgo, MexicoNuclear factor erythroid 2-related factor 2 (Nrf2) is a powerful nuclear transcription factor that coordinates an antioxidant cytoprotector system complex stimulated by the increase in inoxidative stress (OS). In the present manuscript, we conduct a review on the evidence that shows the effect different modalities of physical exercise exert on the antioxidant metabolic response directed by Nrf2. During physical exercise, the reactive oxygen species (ROS) are increased; therefore, if the endogenous and exogenous antioxidant defenses are unable to control the elevation of ROS, the resulting OS triggers the activation of the transcriptional factor Nrf2 to induce the antioxidant response. On a molecular basis related to physical exercise, hormesis maintenance (exercise preconditioning) and adaptative changes in training are supported by a growing body of evidence, which is important for detailing the health benefits that involve greater resistance to environmental aggressions, better tolerance to constant changes, and increasing the regenerative capacity of the cells in such a way that it may be used as a tool to support the prevention or treatment of diseases. This may have clinical implications for future investigations regarding physical exercise in terms of understanding adaptations in high-performance athletes but also as a therapeutic model in several diseases.https://www.mdpi.com/2076-3921/8/6/196oxidative stressNrf2antioxidantsexercise trainingadaptative response |
| spellingShingle | Nancy Vargas-Mendoza Ángel Morales-González Eduardo Osiris Madrigal-Santillán Eduardo Madrigal-Bujaidar Isela Álvarez-González Luis Fernando García-Melo Liliana Anguiano-Robledo Tomás Fregoso-Aguilar José A. Morales-Gonzalez Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise Antioxidants oxidative stress Nrf2 antioxidants exercise training adaptative response |
| title | Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise |
| title_full | Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise |
| title_fullStr | Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise |
| title_full_unstemmed | Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise |
| title_short | Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise |
| title_sort | antioxidant and adaptative response mediated by nrf2 during physical exercise |
| topic | oxidative stress Nrf2 antioxidants exercise training adaptative response |
| url | https://www.mdpi.com/2076-3921/8/6/196 |
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