Seroprevalence of Toxoplasma gondii in domestic pigs, sheep, cattle, wild boars, and moose in the Nordic-Baltic region: A systematic review and meta-analysis
Background: Toxoplasma gondii is an important foodborne zoonotic parasite. Meat of infected animals is presumed to constitute a major source of human infection and may be a driver of geographical variation in the prevalence of anti-T. gondii antibodies in humans, which is substantial in the Nordic-B...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-05-01
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| Series: | Parasite Epidemiology and Control |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405673119300157 |
| _version_ | 1818240692357431296 |
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| author | Abbey Olsen Rebecca Berg Maarja Tagel Kärt Must Gunita Deksne Heidi Larsen Enemark Lis Alban Maria Vang Johansen Henrik Vedel Nielsen Marianne Sandberg Anna Lundén Christen Rune Stensvold Sara M. Pires Pikka Jokelainen |
| author_facet | Abbey Olsen Rebecca Berg Maarja Tagel Kärt Must Gunita Deksne Heidi Larsen Enemark Lis Alban Maria Vang Johansen Henrik Vedel Nielsen Marianne Sandberg Anna Lundén Christen Rune Stensvold Sara M. Pires Pikka Jokelainen |
| author_sort | Abbey Olsen |
| collection | DOAJ |
| description | Background: Toxoplasma gondii is an important foodborne zoonotic parasite. Meat of infected animals is presumed to constitute a major source of human infection and may be a driver of geographical variation in the prevalence of anti-T. gondii antibodies in humans, which is substantial in the Nordic-Baltic region in northern Europe. However, data on seroprevalence of T. gondii in different animal species used for human consumption are scattered. Methods: We conducted a systematic review of seroprevalence studies and meta-analysis to estimate the seroprevalence of T. gondii in five animal species that are raised or hunted for human consumption in the Nordic-Baltic region: domestic pigs (Sus scrofa domesticus), sheep (Ovis aries), cattle (Bos taurus), wild boars (Sus scrofa), and moose (Alces alces). We searched for studies that were conducted between January 1990 and June 2018, and reported in articles, theses, conference abstracts and proceedings, and manuscripts. Subgroup analyses were performed to identify variables influencing the seroprevalence. Findings: From a total of 271 studies identified in the systematic review, 32 were included in the meta-analysis. These comprised of 13 studies on domestic pigs, six on sheep, three on cattle, six on wild boars, and four on moose. The estimated pooled seroprevalence of T. gondii was 6% in domestic pigs (CI95%: 3–10%), 23% in sheep (CI95%: 12–36%), 7% in cattle (CI95%: 1–21%), 33% in wild boars (CI95%: 26–41%), and 16% in moose (CI95%: 10–23%). High heterogeneity was observed in the seroprevalence data within each species. In all host species except wild boars, the pooled seroprevalence estimates were significantly higher in animals >1 year of age than in younger animals. Not all studies provided information on animal age, sensitivity and specificity of the serological method employed, and the cut-off values used for defining an animal seropositive. Conclusions: A substantial proportion of animals raised or hunted for human consumption in the region had tested positive for T. gondii. This indicates widespread exposure to T. gondii among animals raised or hunted for human consumption in the region. Large variations were observed in the seroprevalence estimates between the studies in the region; however, studies were too few to identify spatial patterns at country-level. Keywords: Food-borne, Meat-borne, Europe, Seroepidemiology, Toxoplasmosis, Zoonosis |
| first_indexed | 2024-12-12T13:17:29Z |
| format | Article |
| id | doaj.art-da7c908e740647408d585451ce9ed93c |
| institution | Directory Open Access Journal |
| issn | 2405-6731 |
| language | English |
| last_indexed | 2024-12-12T13:17:29Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Parasite Epidemiology and Control |
| spelling | doaj.art-da7c908e740647408d585451ce9ed93c2022-12-22T00:23:23ZengElsevierParasite Epidemiology and Control2405-67312019-05-015Seroprevalence of Toxoplasma gondii in domestic pigs, sheep, cattle, wild boars, and moose in the Nordic-Baltic region: A systematic review and meta-analysisAbbey Olsen0Rebecca Berg1Maarja Tagel2Kärt Must3Gunita Deksne4Heidi Larsen Enemark5Lis Alban6Maria Vang Johansen7Henrik Vedel Nielsen8Marianne Sandberg9Anna Lundén10Christen Rune Stensvold11Sara M. Pires12Pikka Jokelainen13Section for Parasitology and Aquatic Pathobiology, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 100, DK-1870 Frederiksberg C, Denmark; Department of Food Safety, Veterinary Issues & Risk Analysis, Danish Agriculture & Food Council, Axelborg, Axeltorv 3, DK-1609 Copenhagen, Denmark; Corresponding author at: Section for Parasitology and Aquatic Pathobiology, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 100, DK-1870 Frederiksberg C, Denmark.Section for Organismal Biology, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg, DenmarkInstitute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Kreutzwaldi 62, 51006 Tartu, EstoniaInstitute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Kreutzwaldi 62, 51006 Tartu, EstoniaDepartment of Parasitology, Institute of Food Safety, Animal Health and Environment “BIOR”, Lejupes Str. 3, LV-1076 Riga, Latvia; Department of Zoology and Animal Ecology, Faculty of Biology, University of Latvia, Jelgavas Str. 1, LV-1004 Riga, LatviaNorwegian Veterinary Institute, Department of Animal Health and Food Safety, P.O. Box 750, Sentrum, NO-0106 Oslo, NorwayDepartment of Food Safety, Veterinary Issues & Risk Analysis, Danish Agriculture & Food Council, Axelborg, Axeltorv 3, DK-1609 Copenhagen, DenmarkSection for Parasitology and Aquatic Pathobiology, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 100, DK-1870 Frederiksberg C, DenmarkLaboratory of Parasitology, Department of Bacteria, Parasites & Fungi, Infectious Disease Preparedness, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, DenmarkDepartment of Food Safety, Veterinary Issues & Risk Analysis, Danish Agriculture & Food Council, Axelborg, Axeltorv 3, DK-1609 Copenhagen, DenmarkNational Veterinary Institute, Department of Microbiology, SE-751 89 Uppsala, SwedenLaboratory of Parasitology, Department of Bacteria, Parasites & Fungi, Infectious Disease Preparedness, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, DenmarkNational Food Institute, Technical University of Denmark, Kemitorvet 201, 2800 Kgs. Lyngby, DenmarkLaboratory of Parasitology, Department of Bacteria, Parasites & Fungi, Infectious Disease Preparedness, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark; Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Kreutzwaldi 62, 51006 Tartu, Estonia; Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 66, 00014 Helsinki, FinlandBackground: Toxoplasma gondii is an important foodborne zoonotic parasite. Meat of infected animals is presumed to constitute a major source of human infection and may be a driver of geographical variation in the prevalence of anti-T. gondii antibodies in humans, which is substantial in the Nordic-Baltic region in northern Europe. However, data on seroprevalence of T. gondii in different animal species used for human consumption are scattered. Methods: We conducted a systematic review of seroprevalence studies and meta-analysis to estimate the seroprevalence of T. gondii in five animal species that are raised or hunted for human consumption in the Nordic-Baltic region: domestic pigs (Sus scrofa domesticus), sheep (Ovis aries), cattle (Bos taurus), wild boars (Sus scrofa), and moose (Alces alces). We searched for studies that were conducted between January 1990 and June 2018, and reported in articles, theses, conference abstracts and proceedings, and manuscripts. Subgroup analyses were performed to identify variables influencing the seroprevalence. Findings: From a total of 271 studies identified in the systematic review, 32 were included in the meta-analysis. These comprised of 13 studies on domestic pigs, six on sheep, three on cattle, six on wild boars, and four on moose. The estimated pooled seroprevalence of T. gondii was 6% in domestic pigs (CI95%: 3–10%), 23% in sheep (CI95%: 12–36%), 7% in cattle (CI95%: 1–21%), 33% in wild boars (CI95%: 26–41%), and 16% in moose (CI95%: 10–23%). High heterogeneity was observed in the seroprevalence data within each species. In all host species except wild boars, the pooled seroprevalence estimates were significantly higher in animals >1 year of age than in younger animals. Not all studies provided information on animal age, sensitivity and specificity of the serological method employed, and the cut-off values used for defining an animal seropositive. Conclusions: A substantial proportion of animals raised or hunted for human consumption in the region had tested positive for T. gondii. This indicates widespread exposure to T. gondii among animals raised or hunted for human consumption in the region. Large variations were observed in the seroprevalence estimates between the studies in the region; however, studies were too few to identify spatial patterns at country-level. Keywords: Food-borne, Meat-borne, Europe, Seroepidemiology, Toxoplasmosis, Zoonosishttp://www.sciencedirect.com/science/article/pii/S2405673119300157 |
| spellingShingle | Abbey Olsen Rebecca Berg Maarja Tagel Kärt Must Gunita Deksne Heidi Larsen Enemark Lis Alban Maria Vang Johansen Henrik Vedel Nielsen Marianne Sandberg Anna Lundén Christen Rune Stensvold Sara M. Pires Pikka Jokelainen Seroprevalence of Toxoplasma gondii in domestic pigs, sheep, cattle, wild boars, and moose in the Nordic-Baltic region: A systematic review and meta-analysis Parasite Epidemiology and Control |
| title | Seroprevalence of Toxoplasma gondii in domestic pigs, sheep, cattle, wild boars, and moose in the Nordic-Baltic region: A systematic review and meta-analysis |
| title_full | Seroprevalence of Toxoplasma gondii in domestic pigs, sheep, cattle, wild boars, and moose in the Nordic-Baltic region: A systematic review and meta-analysis |
| title_fullStr | Seroprevalence of Toxoplasma gondii in domestic pigs, sheep, cattle, wild boars, and moose in the Nordic-Baltic region: A systematic review and meta-analysis |
| title_full_unstemmed | Seroprevalence of Toxoplasma gondii in domestic pigs, sheep, cattle, wild boars, and moose in the Nordic-Baltic region: A systematic review and meta-analysis |
| title_short | Seroprevalence of Toxoplasma gondii in domestic pigs, sheep, cattle, wild boars, and moose in the Nordic-Baltic region: A systematic review and meta-analysis |
| title_sort | seroprevalence of toxoplasma gondii in domestic pigs sheep cattle wild boars and moose in the nordic baltic region a systematic review and meta analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2405673119300157 |
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