Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
Caspases are most closely associated with cell death, but many have other cellular functions. Here, Das et al. find that upon metabolic stress, caspase-10 cleaves ACLY to regulate metabolic homeostasis and epigenetic reprogramming by altering Acetyl-CoA levels.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12194-6 |
| _version_ | 1818342195511427072 |
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| author | Rajni Kumari Ruhi S. Deshmukh Sanjeev Das |
| author_facet | Rajni Kumari Ruhi S. Deshmukh Sanjeev Das |
| author_sort | Rajni Kumari |
| collection | DOAJ |
| description | Caspases are most closely associated with cell death, but many have other cellular functions. Here, Das et al. find that upon metabolic stress, caspase-10 cleaves ACLY to regulate metabolic homeostasis and epigenetic reprogramming by altering Acetyl-CoA levels. |
| first_indexed | 2024-12-13T16:10:50Z |
| format | Article |
| id | doaj.art-da7fe8cd0b86475f9a5a54a875ed8c64 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:10:50Z |
| publishDate | 2019-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-da7fe8cd0b86475f9a5a54a875ed8c642022-12-21T23:38:56ZengNature PortfolioNature Communications2041-17232019-09-0110111510.1038/s41467-019-12194-6Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesisRajni Kumari0Ruhi S. Deshmukh1Sanjeev Das2Molecular Oncology Laboratory, National Institute of ImmunologyMolecular Oncology Laboratory, National Institute of ImmunologyMolecular Oncology Laboratory, National Institute of ImmunologyCaspases are most closely associated with cell death, but many have other cellular functions. Here, Das et al. find that upon metabolic stress, caspase-10 cleaves ACLY to regulate metabolic homeostasis and epigenetic reprogramming by altering Acetyl-CoA levels.https://doi.org/10.1038/s41467-019-12194-6 |
| spellingShingle | Rajni Kumari Ruhi S. Deshmukh Sanjeev Das Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis Nature Communications |
| title | Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis |
| title_full | Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis |
| title_fullStr | Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis |
| title_full_unstemmed | Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis |
| title_short | Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis |
| title_sort | caspase 10 inhibits atp citrate lyase mediated metabolic and epigenetic reprogramming to suppress tumorigenesis |
| url | https://doi.org/10.1038/s41467-019-12194-6 |
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