Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population
Abstract Background Visual rating of medial temporal lobe atrophy (MTA) is often performed in conjunction with dementia workup. Most prior studies involved patients with known or probable Alzheimer’s disease (AD). This study investigated the validity and reliability of MTA in a memory clinic populat...
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-021-02325-2 |
| _version_ | 1819134590474780672 |
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| author | Anna Molinder Doerthe Ziegelitz Stephan E. Maier Carl Eckerström |
| author_facet | Anna Molinder Doerthe Ziegelitz Stephan E. Maier Carl Eckerström |
| author_sort | Anna Molinder |
| collection | DOAJ |
| description | Abstract Background Visual rating of medial temporal lobe atrophy (MTA) is often performed in conjunction with dementia workup. Most prior studies involved patients with known or probable Alzheimer’s disease (AD). This study investigated the validity and reliability of MTA in a memory clinic population. Methods MTA was rated in 752 MRI examinations, of which 105 were performed in cognitively healthy participants (CH), 184 in participants with subjective cognitive impairment, 249 in subjects with mild cognitive impairment, and 214 in patients with dementia, including AD, subcortical vascular dementia and mixed dementia. Hippocampal volumes, measured manually or using FreeSurfer, were available in the majority of cases. Intra- and interrater reliability was tested using Cohen’s weighted kappa. Correlation between MTA and quantitative hippocampal measurements was ascertained with Spearman’s rank correlation coefficient. Moreover, diagnostic ability of MTA was assessed with receiver operating characteristic (ROC) analysis and suitable, age-dependent MTA thresholds were determined. Results Rater agreement was moderate to substantial. MTA correlation with quantitative volumetric methods ranged from -0.20 (p< 0.05) to -0.68 (p < 0.001) depending on the quantitative method used. Both MTA and FreeSurfer are able to distinguish dementia subgroups from CH. Suggested age-dependent MTA thresholds are 1 for the age group below 75 years and 1.5 for the age group 75 years and older. Conclusions MTA can be considered a valid marker of medial temporal lobe atrophy and may thus be valuable in the assessment of patients with cognitive impairment, even in a heterogeneous patient population. |
| first_indexed | 2024-12-22T10:05:37Z |
| format | Article |
| id | doaj.art-da8000ef29a24b1caa2f2c5312a68499 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-22T10:05:37Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-da8000ef29a24b1caa2f2c5312a684992022-12-21T18:29:58ZengBMCBMC Neurology1471-23772021-07-0121111010.1186/s12883-021-02325-2Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic populationAnna Molinder0Doerthe Ziegelitz1Stephan E. Maier2Carl Eckerström3Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of GothenburgDepartment of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of GothenburgDepartment of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of GothenburgDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of GothenburgAbstract Background Visual rating of medial temporal lobe atrophy (MTA) is often performed in conjunction with dementia workup. Most prior studies involved patients with known or probable Alzheimer’s disease (AD). This study investigated the validity and reliability of MTA in a memory clinic population. Methods MTA was rated in 752 MRI examinations, of which 105 were performed in cognitively healthy participants (CH), 184 in participants with subjective cognitive impairment, 249 in subjects with mild cognitive impairment, and 214 in patients with dementia, including AD, subcortical vascular dementia and mixed dementia. Hippocampal volumes, measured manually or using FreeSurfer, were available in the majority of cases. Intra- and interrater reliability was tested using Cohen’s weighted kappa. Correlation between MTA and quantitative hippocampal measurements was ascertained with Spearman’s rank correlation coefficient. Moreover, diagnostic ability of MTA was assessed with receiver operating characteristic (ROC) analysis and suitable, age-dependent MTA thresholds were determined. Results Rater agreement was moderate to substantial. MTA correlation with quantitative volumetric methods ranged from -0.20 (p< 0.05) to -0.68 (p < 0.001) depending on the quantitative method used. Both MTA and FreeSurfer are able to distinguish dementia subgroups from CH. Suggested age-dependent MTA thresholds are 1 for the age group below 75 years and 1.5 for the age group 75 years and older. Conclusions MTA can be considered a valid marker of medial temporal lobe atrophy and may thus be valuable in the assessment of patients with cognitive impairment, even in a heterogeneous patient population.https://doi.org/10.1186/s12883-021-02325-2DementiaMedial temporal lobe atrophy (MTA)Alzheimer’s diseaseMild cognitive impairmentAtrophyMagnetic resonance imaging |
| spellingShingle | Anna Molinder Doerthe Ziegelitz Stephan E. Maier Carl Eckerström Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population BMC Neurology Dementia Medial temporal lobe atrophy (MTA) Alzheimer’s disease Mild cognitive impairment Atrophy Magnetic resonance imaging |
| title | Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population |
| title_full | Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population |
| title_fullStr | Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population |
| title_full_unstemmed | Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population |
| title_short | Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population |
| title_sort | validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population |
| topic | Dementia Medial temporal lobe atrophy (MTA) Alzheimer’s disease Mild cognitive impairment Atrophy Magnetic resonance imaging |
| url | https://doi.org/10.1186/s12883-021-02325-2 |
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