Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffolds
Reticulated åkermanite (Ca2MgSi2O7) 3D scaffolds were fabricated by direct ink writing of pastes based on a commercial silicone resin and fillers, such as calcium carbonate (CaCO3) and magnesium hydroxide (Mg(OH)2) microparticles, followed by heat treatment at 1100 °C in air. To form liquid phase up...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Open Ceramics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666539523000858 |
| _version_ | 1797736235747246080 |
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| author | Fulden Dogrul Vera Bednarzig Hamada Elsayed Liliana Liverani Dušan Galusek Enrico Bernardo Aldo R. Boccaccini |
| author_facet | Fulden Dogrul Vera Bednarzig Hamada Elsayed Liliana Liverani Dušan Galusek Enrico Bernardo Aldo R. Boccaccini |
| author_sort | Fulden Dogrul |
| collection | DOAJ |
| description | Reticulated åkermanite (Ca2MgSi2O7) 3D scaffolds were fabricated by direct ink writing of pastes based on a commercial silicone resin and fillers, such as calcium carbonate (CaCO3) and magnesium hydroxide (Mg(OH)2) microparticles, followed by heat treatment at 1100 °C in air. To form liquid phase upon firing and thus promote the ionic interdiffusion, borax (Na2B4O7·10H2O) or hydrated sodium phosphate (Na2HPO4·12H2O) were considered as alternative additives. Although leading to scaffolds with different strength-to-density ratio, the two additives did not lead to substantial differences in terms of biological response. All fabricated ceramics exhibited acellular in-vitro bioactivity upon immersion in simulated-body-fluid (SBF) as well as antibacterial activity against S. aureus and E. coli. Direct contact cell viability test, performed with a stromal-cell line from mouse bone marrow (ST-2 cells), indicated no cytotoxicity of both samples determined by the WST-8 assay. |
| first_indexed | 2024-03-12T13:10:43Z |
| format | Article |
| id | doaj.art-da804063c7df433c89879ee4c68d9b13 |
| institution | Directory Open Access Journal |
| issn | 2666-5395 |
| language | English |
| last_indexed | 2024-03-12T13:10:43Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Open Ceramics |
| spelling | doaj.art-da804063c7df433c89879ee4c68d9b132023-08-28T04:23:22ZengElsevierOpen Ceramics2666-53952023-09-0115100413Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffoldsFulden Dogrul0Vera Bednarzig1Hamada Elsayed2Liliana Liverani3Dušan Galusek4Enrico Bernardo5Aldo R. Boccaccini6FunGlass – Centre for Functional and Surface Functionalized Glass, Alexander Dubček University of Trenčín, Trenčín, Slovakia; Department of Industrial Engineering, Università Degli Studi di Padova, Padova, Italy; Institute of Biomaterials, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Cauerstraße 6, 91058 Erlangen, GermanyInstitute of Biomaterials, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Cauerstraße 6, 91058 Erlangen, GermanyDepartment of Industrial Engineering, Università Degli Studi di Padova, Padova, Italy; Department of Glass Research, National Research Centre, EgyptInstitute of Biomaterials, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Cauerstraße 6, 91058 Erlangen, Germany; DGS S.p.A., Rome, ItalyFunGlass – Centre for Functional and Surface Functionalized Glass, Alexander Dubček University of Trenčín, Trenčín, Slovakia; Joint Glass Centre of the IIC SAS, TnU AD and FChFT STU, Centre for Functional and Surface Functionalized Glass, TnUAD, Trenčín, SlovakiaDepartment of Industrial Engineering, Università Degli Studi di Padova, Padova, Italy; Corresponding author.Institute of Biomaterials, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Cauerstraße 6, 91058 Erlangen, Germany; Corresponding author.Reticulated åkermanite (Ca2MgSi2O7) 3D scaffolds were fabricated by direct ink writing of pastes based on a commercial silicone resin and fillers, such as calcium carbonate (CaCO3) and magnesium hydroxide (Mg(OH)2) microparticles, followed by heat treatment at 1100 °C in air. To form liquid phase upon firing and thus promote the ionic interdiffusion, borax (Na2B4O7·10H2O) or hydrated sodium phosphate (Na2HPO4·12H2O) were considered as alternative additives. Although leading to scaffolds with different strength-to-density ratio, the two additives did not lead to substantial differences in terms of biological response. All fabricated ceramics exhibited acellular in-vitro bioactivity upon immersion in simulated-body-fluid (SBF) as well as antibacterial activity against S. aureus and E. coli. Direct contact cell viability test, performed with a stromal-cell line from mouse bone marrow (ST-2 cells), indicated no cytotoxicity of both samples determined by the WST-8 assay.http://www.sciencedirect.com/science/article/pii/S2666539523000858ÅkermaniteScaffoldPolymer-derived-ceramicDirect ink writing (DIW)BioceramicBioactivity |
| spellingShingle | Fulden Dogrul Vera Bednarzig Hamada Elsayed Liliana Liverani Dušan Galusek Enrico Bernardo Aldo R. Boccaccini Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffolds Open Ceramics Åkermanite Scaffold Polymer-derived-ceramic Direct ink writing (DIW) Bioceramic Bioactivity |
| title | Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffolds |
| title_full | Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffolds |
| title_fullStr | Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffolds |
| title_full_unstemmed | Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffolds |
| title_short | Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffolds |
| title_sort | assessment of in vitro bioactivity biodegradability and antibacterial activity of polymer derived 3d printed akermanite scaffolds |
| topic | Åkermanite Scaffold Polymer-derived-ceramic Direct ink writing (DIW) Bioceramic Bioactivity |
| url | http://www.sciencedirect.com/science/article/pii/S2666539523000858 |
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