Optogenetic regulation of transcription
Abstract Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to tran...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-04-01
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| Series: | BMC Neuroscience |
| Online Access: | http://link.springer.com/article/10.1186/s12868-018-0411-6 |
| _version_ | 1828491757179895808 |
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| author | Oksana Polesskaya Ancha Baranova Sarah Bui Nikolai Kondratev Evgeniya Kananykhina Olga Nazarenko Tatyana Shapiro Frances Barg Nardia Vladimir Kornienko Vikas Chandhoke Istvan Stadler Raymond Lanzafame Max Myakishev-Rempel |
| author_facet | Oksana Polesskaya Ancha Baranova Sarah Bui Nikolai Kondratev Evgeniya Kananykhina Olga Nazarenko Tatyana Shapiro Frances Barg Nardia Vladimir Kornienko Vikas Chandhoke Istvan Stadler Raymond Lanzafame Max Myakishev-Rempel |
| author_sort | Oksana Polesskaya |
| collection | DOAJ |
| description | Abstract Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to transduce the signal to regulate gene transcription, and its possible use in medicine. One of the problems with existing gene therapies is that they could remain active indefinitely while not allowing regulated transgene production on demand. Optogenetic regulation of transcription (ORT) could potentially be used to regulate the production of a biological drug in situ, by repeatedly applying light to the tissue, and inducing expression of therapeutic transgenes when needed. Red and near infrared wavelengths, which are capable of penetration into tissues, have potential for therapeutic applications. Existing ORT systems are reviewed herein with these considerations in mind. |
| first_indexed | 2024-12-11T11:08:23Z |
| format | Article |
| id | doaj.art-da80bf6c5793414782f7c0aee8747684 |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-12-11T11:08:23Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-da80bf6c5793414782f7c0aee87476842022-12-22T01:09:38ZengBMCBMC Neuroscience1471-22022018-04-0119S131310.1186/s12868-018-0411-6Optogenetic regulation of transcriptionOksana Polesskaya0Ancha Baranova1Sarah Bui2Nikolai Kondratev3Evgeniya Kananykhina4Olga Nazarenko5Tatyana Shapiro6Frances Barg Nardia7Vladimir Kornienko8Vikas Chandhoke9Istvan Stadler10Raymond Lanzafame11Max Myakishev-Rempel12University of CaliforniaResearch Center for Medical Genetics RAMSCenter for the Study of Chronic Metabolic and Rare Diseases, School of Systems Biology, George Mason UniversityLocalized Therapeutics, LLCLocalized Therapeutics, LLCLocalized Therapeutics, LLCLocalized Therapeutics, LLCLocalized Therapeutics, LLCLocalized Therapeutics, LLCCenter for the Study of Chronic Metabolic and Rare Diseases, School of Systems Biology, George Mason UniversityRochester General HospitalRaymond J. Lanzafame, MD PLLCLocalized Therapeutics, LLCAbstract Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to transduce the signal to regulate gene transcription, and its possible use in medicine. One of the problems with existing gene therapies is that they could remain active indefinitely while not allowing regulated transgene production on demand. Optogenetic regulation of transcription (ORT) could potentially be used to regulate the production of a biological drug in situ, by repeatedly applying light to the tissue, and inducing expression of therapeutic transgenes when needed. Red and near infrared wavelengths, which are capable of penetration into tissues, have potential for therapeutic applications. Existing ORT systems are reviewed herein with these considerations in mind.http://link.springer.com/article/10.1186/s12868-018-0411-6 |
| spellingShingle | Oksana Polesskaya Ancha Baranova Sarah Bui Nikolai Kondratev Evgeniya Kananykhina Olga Nazarenko Tatyana Shapiro Frances Barg Nardia Vladimir Kornienko Vikas Chandhoke Istvan Stadler Raymond Lanzafame Max Myakishev-Rempel Optogenetic regulation of transcription BMC Neuroscience |
| title | Optogenetic regulation of transcription |
| title_full | Optogenetic regulation of transcription |
| title_fullStr | Optogenetic regulation of transcription |
| title_full_unstemmed | Optogenetic regulation of transcription |
| title_short | Optogenetic regulation of transcription |
| title_sort | optogenetic regulation of transcription |
| url | http://link.springer.com/article/10.1186/s12868-018-0411-6 |
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