Ultrasonic and microwave activation of raspberry extract: antioxidant and anti-carcinogenic properties
Safe and healthy nutrition has a beneficial effect on human well-being. Various foods, such as berries, are known to inhibit cancer-promoting pre-proliferative signals. Among European fruit and berry crops, raspberries demonstrate one with the widest ranges of biologically active substances. Extract...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Kemerovo State University
2019-10-01
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| Series: | Foods and Raw Materials |
| Subjects: | |
| Online Access: | http://jfrm.ru/files/archive/14/6.pdf |
| _version_ | 1819132555466637312 |
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| author | Natalia B. Eremeeva Nadezhda V. Makarova Ekaterina M. Zhidkova Varvara P. Maximova Ekaterina A. Lesova |
| author_facet | Natalia B. Eremeeva Nadezhda V. Makarova Ekaterina M. Zhidkova Varvara P. Maximova Ekaterina A. Lesova |
| author_sort | Natalia B. Eremeeva |
| collection | DOAJ |
| description | Safe and healthy nutrition has a beneficial effect on human well-being. Various foods, such as berries, are known to inhibit cancer-promoting pre-proliferative signals. Among European fruit and berry crops, raspberries demonstrate one with the widest ranges of biologically active substances. Extraction remains a reliable method of obtaining biologically active substances from plant materials. The research objective was to obtain a semi-finished raspberry product by using microwave and ultrasonic processing and to study its antioxidant, anti-carcinogenic, sensory, physico-chemical, and microbiological properties. The raspberry extracts were obtained by maceration, ultrasound treatment, and microwave processing. After that, the samples underwent a comparative analysis of their antioxidant properties. The ultrasonic method gave the best results. A set of experiments made it possible to define the optimal technological modes for the extraction process: ethanol = 50%, ultrasonic radiation = 35 kHz, temperature = 40 ± 5°C, time = 120 min, water ratio = 1:10. A set of experiments on cell cultures demonstrated that the raspberry extract was able to reduce the expression of the anti-inflammatory COX-2, iNOS, and IL-8 genes. Hense, we recommend further studies of the effect of the raspberry extract on the induced expression of COX-2, iNOS, and IL-8. In addition, its anticarcinogenic properties have to be studied in vivo. |
| first_indexed | 2024-12-22T09:33:16Z |
| format | Article |
| id | doaj.art-da81927402b1470eaceb2b62f3f78d1f |
| institution | Directory Open Access Journal |
| issn | 2308-4057 2310-9599 |
| language | English |
| last_indexed | 2024-12-22T09:33:16Z |
| publishDate | 2019-10-01 |
| publisher | Kemerovo State University |
| record_format | Article |
| series | Foods and Raw Materials |
| spelling | doaj.art-da81927402b1470eaceb2b62f3f78d1f2022-12-21T18:30:53ZengKemerovo State UniversityFoods and Raw Materials2308-40572310-95992019-10-017226427310.21603/2308-4057-2019-2-264-273Ultrasonic and microwave activation of raspberry extract: antioxidant and anti-carcinogenic propertiesNatalia B. Eremeeva0Nadezhda V. Makarova1Ekaterina M. Zhidkova2Varvara P. Maximova3Ekaterina A. Lesova4Samara State Technical UniversitySamara State Technical UniversityN.N. Blokhin National Medical Research Centre of oncologyN.N. Blokhin National Medical Research Centre of oncologyN.N. Blokhin National Medical Research Centre of oncologySafe and healthy nutrition has a beneficial effect on human well-being. Various foods, such as berries, are known to inhibit cancer-promoting pre-proliferative signals. Among European fruit and berry crops, raspberries demonstrate one with the widest ranges of biologically active substances. Extraction remains a reliable method of obtaining biologically active substances from plant materials. The research objective was to obtain a semi-finished raspberry product by using microwave and ultrasonic processing and to study its antioxidant, anti-carcinogenic, sensory, physico-chemical, and microbiological properties. The raspberry extracts were obtained by maceration, ultrasound treatment, and microwave processing. After that, the samples underwent a comparative analysis of their antioxidant properties. The ultrasonic method gave the best results. A set of experiments made it possible to define the optimal technological modes for the extraction process: ethanol = 50%, ultrasonic radiation = 35 kHz, temperature = 40 ± 5°C, time = 120 min, water ratio = 1:10. A set of experiments on cell cultures demonstrated that the raspberry extract was able to reduce the expression of the anti-inflammatory COX-2, iNOS, and IL-8 genes. Hense, we recommend further studies of the effect of the raspberry extract on the induced expression of COX-2, iNOS, and IL-8. In addition, its anticarcinogenic properties have to be studied in vivo.http://jfrm.ru/files/archive/14/6.pdfExtraction of plant materialsphenolic substancesPRC-analysisexpression of anti-inflammatory genesinhibitionultrasoundmicrovaves |
| spellingShingle | Natalia B. Eremeeva Nadezhda V. Makarova Ekaterina M. Zhidkova Varvara P. Maximova Ekaterina A. Lesova Ultrasonic and microwave activation of raspberry extract: antioxidant and anti-carcinogenic properties Foods and Raw Materials Extraction of plant materials phenolic substances PRC-analysis expression of anti-inflammatory genes inhibition ultrasound microvaves |
| title | Ultrasonic and microwave activation of raspberry extract: antioxidant and anti-carcinogenic properties |
| title_full | Ultrasonic and microwave activation of raspberry extract: antioxidant and anti-carcinogenic properties |
| title_fullStr | Ultrasonic and microwave activation of raspberry extract: antioxidant and anti-carcinogenic properties |
| title_full_unstemmed | Ultrasonic and microwave activation of raspberry extract: antioxidant and anti-carcinogenic properties |
| title_short | Ultrasonic and microwave activation of raspberry extract: antioxidant and anti-carcinogenic properties |
| title_sort | ultrasonic and microwave activation of raspberry extract antioxidant and anti carcinogenic properties |
| topic | Extraction of plant materials phenolic substances PRC-analysis expression of anti-inflammatory genes inhibition ultrasound microvaves |
| url | http://jfrm.ru/files/archive/14/6.pdf |
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