Preparation of Alginate Microspheres for the Delivery of Risperidone
Aim: The aim of this research is to prepare and evaluate alginate microspheres of prolonged delivery of a model drug, Risperidone. Methods: Alginate microspheres containing Risperidone were prepared employing cross-linking method by calcium chloride. The formed microspheres were evaluated for percen...
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| Format: | Article |
| Language: | English |
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University of Science and Technology, Yemen
2014-12-01
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| Series: | Yemeni Journal for Medical Sciences |
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| Online Access: | https://journals.ust.edu/index.php/yjms/article/view/779 |
| _version_ | 1811334474207592448 |
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| author | Al-Tahami K. |
| author_facet | Al-Tahami K. |
| author_sort | Al-Tahami K. |
| collection | DOAJ |
| description | Aim: The aim of this research is to prepare and evaluate alginate microspheres of prolonged delivery of a model drug, Risperidone. Methods: Alginate microspheres containing Risperidone were prepared employing cross-linking method by calcium chloride. The formed microspheres were evaluated for percentage yield, drug content, drug loading, and encapsulation efficiency. In vitro release studies were carried out in phosphate buffer (pH 7.4). Results: The formed microspheres exhibited good drug loading and encapsulation efficiency. The drug release was sustained over a period of 8 hours. Conclusions: The fabricated Risperidone microspheres showed extended drug release, which could improve the therapeutic agent bioavailability and increase patient compliance. The delivery system developed can potentially serve for the delivery of many therapeutic agents. |
| first_indexed | 2024-04-13T17:09:24Z |
| format | Article |
| id | doaj.art-da81c5ce7c514789bcf3c54b720dc331 |
| institution | Directory Open Access Journal |
| issn | 2227-9601 2227-961X |
| language | English |
| last_indexed | 2024-04-13T17:09:24Z |
| publishDate | 2014-12-01 |
| publisher | University of Science and Technology, Yemen |
| record_format | Article |
| series | Yemeni Journal for Medical Sciences |
| spelling | doaj.art-da81c5ce7c514789bcf3c54b720dc3312022-12-22T02:38:21ZengUniversity of Science and Technology, YemenYemeni Journal for Medical Sciences2227-96012227-961X2014-12-0181192310.20428/YJMS.8.1.4734Preparation of Alginate Microspheres for the Delivery of RisperidoneAl-Tahami K.0Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Science and Technology, Sana’a, YemenAim: The aim of this research is to prepare and evaluate alginate microspheres of prolonged delivery of a model drug, Risperidone. Methods: Alginate microspheres containing Risperidone were prepared employing cross-linking method by calcium chloride. The formed microspheres were evaluated for percentage yield, drug content, drug loading, and encapsulation efficiency. In vitro release studies were carried out in phosphate buffer (pH 7.4). Results: The formed microspheres exhibited good drug loading and encapsulation efficiency. The drug release was sustained over a period of 8 hours. Conclusions: The fabricated Risperidone microspheres showed extended drug release, which could improve the therapeutic agent bioavailability and increase patient compliance. The delivery system developed can potentially serve for the delivery of many therapeutic agents.https://journals.ust.edu/index.php/yjms/article/view/779alginatemicrospheressustained releaserisperidone |
| spellingShingle | Al-Tahami K. Preparation of Alginate Microspheres for the Delivery of Risperidone Yemeni Journal for Medical Sciences alginate microspheres sustained release risperidone |
| title | Preparation of Alginate Microspheres for the Delivery of Risperidone |
| title_full | Preparation of Alginate Microspheres for the Delivery of Risperidone |
| title_fullStr | Preparation of Alginate Microspheres for the Delivery of Risperidone |
| title_full_unstemmed | Preparation of Alginate Microspheres for the Delivery of Risperidone |
| title_short | Preparation of Alginate Microspheres for the Delivery of Risperidone |
| title_sort | preparation of alginate microspheres for the delivery of risperidone |
| topic | alginate microspheres sustained release risperidone |
| url | https://journals.ust.edu/index.php/yjms/article/view/779 |
| work_keys_str_mv | AT altahamik preparationofalginatemicrospheresforthedeliveryofrisperidone |