Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides – a randomized controlled trial
IntroductionCollagen peptide supplementation in conjunction with exercise has been shown to improve structural and functional adaptations of both muscles and the extracellular matrix. This study aimed to explore whether specific collagen peptide (SCP) supplementation combined with a concurrent train...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1384112/full |
| _version_ | 1827309795999219712 |
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| author | Kevin Bischof Kevin Bischof Savvas Stafilidis Larissa Bundschuh Steffen Oesser Arnold Baca Arnold Baca Daniel König Daniel König Daniel König |
| author_facet | Kevin Bischof Kevin Bischof Savvas Stafilidis Larissa Bundschuh Steffen Oesser Arnold Baca Arnold Baca Daniel König Daniel König Daniel König |
| author_sort | Kevin Bischof |
| collection | DOAJ |
| description | IntroductionCollagen peptide supplementation in conjunction with exercise has been shown to improve structural and functional adaptations of both muscles and the extracellular matrix. This study aimed to explore whether specific collagen peptide (SCP) supplementation combined with a concurrent training intervention can improve muscular stress after exercise-induced muscle damage, verified by reliable blood markers.Methods55 sedentary to moderately active males participating in a concurrent training (CT) intervention (3x/week) for 12 weeks were administered either 15 g of SCP or placebo (PLA) daily. Before (T1) and after the intervention (T2), 150 muscle-damaging drop jumps were performed. Blood samples were collected to measure creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin (MYO) and high-sensitivity C-reactive protein (hsCRP) before, after, and at 2 h, 24 h and 48 h post exercise.ResultsA combination of concurrent training and SCP administration showed statistically significant interaction effects, implying a lower increase in the area under the curve (AUC) of MYO (p = 0.004, ηp2 = 0.184), CK (p = 0.01, ηp2 = 0.145) and LDH (p = 0.016, ηp2 = 0.133) in the SCP group. On closer examination, the absolute mean differences (ΔAUCs) showed statistical significance in MYO (p = 0.017, d = 0.771), CK (p = 0.039, d = 0.633) and LDH (p = 0.016, d = 0.764) by SCP supplementation.ConclusionIn conclusion, 12 weeks of 15 g SCP supplementation combined with CT intervention reduced acute markers of exercise-induced muscle damage and improved post-exercise regenerative capacity, as evidenced by the altered post-exercise time course. The current findings indicate that SCP supplementation had a positive effect on the early phase of muscular recovery by either improving the structural integrity of the muscle and extracellular matrix during the training period or by accelerating membrane and cytoskeletal protein repair.Clinical trial registrationhttps://www.clinicaltrials.gov/study/NCT05220371?cond=NCT05220371&rank=1, NCT05220371. |
| first_indexed | 2024-04-24T19:47:52Z |
| format | Article |
| id | doaj.art-da830dcc247946788817d39cd3b7642b |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-24T19:47:52Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-da830dcc247946788817d39cd3b7642b2024-03-25T04:41:37ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-03-011110.3389/fnut.2024.13841121384112Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides – a randomized controlled trialKevin Bischof0Kevin Bischof1Savvas Stafilidis2Larissa Bundschuh3Steffen Oesser4Arnold Baca5Arnold Baca6Daniel König7Daniel König8Daniel König9Centre for Sports Science and University Sports, Department of Sports Science, Section for Nutrition, Exercise and Health, University of Vienna, Vienna, AustriaVienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Vienna, AustriaCentre for Sports Science and University Sports, Department for Biomechanics, Kinesiology and Computer Science in Sport, University of Vienna, Vienna, AustriaCentre for Sports Science and University Sports, Department of Sports Science, Section for Nutrition, Exercise and Health, University of Vienna, Vienna, AustriaCRI, Collagen Research Institute, Kiel, GermanyVienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Vienna, AustriaCentre for Sports Science and University Sports, Department for Biomechanics, Kinesiology and Computer Science in Sport, University of Vienna, Vienna, AustriaCentre for Sports Science and University Sports, Department of Sports Science, Section for Nutrition, Exercise and Health, University of Vienna, Vienna, AustriaVienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Vienna, AustriaFaculty of Life Sciences, Department for Nutrition, Section for Nutrition, Exercise and Health, University of Vienna, Vienna, AustriaIntroductionCollagen peptide supplementation in conjunction with exercise has been shown to improve structural and functional adaptations of both muscles and the extracellular matrix. This study aimed to explore whether specific collagen peptide (SCP) supplementation combined with a concurrent training intervention can improve muscular stress after exercise-induced muscle damage, verified by reliable blood markers.Methods55 sedentary to moderately active males participating in a concurrent training (CT) intervention (3x/week) for 12 weeks were administered either 15 g of SCP or placebo (PLA) daily. Before (T1) and after the intervention (T2), 150 muscle-damaging drop jumps were performed. Blood samples were collected to measure creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin (MYO) and high-sensitivity C-reactive protein (hsCRP) before, after, and at 2 h, 24 h and 48 h post exercise.ResultsA combination of concurrent training and SCP administration showed statistically significant interaction effects, implying a lower increase in the area under the curve (AUC) of MYO (p = 0.004, ηp2 = 0.184), CK (p = 0.01, ηp2 = 0.145) and LDH (p = 0.016, ηp2 = 0.133) in the SCP group. On closer examination, the absolute mean differences (ΔAUCs) showed statistical significance in MYO (p = 0.017, d = 0.771), CK (p = 0.039, d = 0.633) and LDH (p = 0.016, d = 0.764) by SCP supplementation.ConclusionIn conclusion, 12 weeks of 15 g SCP supplementation combined with CT intervention reduced acute markers of exercise-induced muscle damage and improved post-exercise regenerative capacity, as evidenced by the altered post-exercise time course. The current findings indicate that SCP supplementation had a positive effect on the early phase of muscular recovery by either improving the structural integrity of the muscle and extracellular matrix during the training period or by accelerating membrane and cytoskeletal protein repair.Clinical trial registrationhttps://www.clinicaltrials.gov/study/NCT05220371?cond=NCT05220371&rank=1, NCT05220371.https://www.frontiersin.org/articles/10.3389/fnut.2024.1384112/fullcollagen peptidesmuscle damageconcurrent trainingrecoveryregenerationcreatine kinase |
| spellingShingle | Kevin Bischof Kevin Bischof Savvas Stafilidis Larissa Bundschuh Steffen Oesser Arnold Baca Arnold Baca Daniel König Daniel König Daniel König Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides – a randomized controlled trial Frontiers in Nutrition collagen peptides muscle damage concurrent training recovery regeneration creatine kinase |
| title | Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides – a randomized controlled trial |
| title_full | Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides – a randomized controlled trial |
| title_fullStr | Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides – a randomized controlled trial |
| title_full_unstemmed | Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides – a randomized controlled trial |
| title_short | Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides – a randomized controlled trial |
| title_sort | reduction in systemic muscle stress markers after exercise induced muscle damage following concurrent training and supplementation with specific collagen peptides a randomized controlled trial |
| topic | collagen peptides muscle damage concurrent training recovery regeneration creatine kinase |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1384112/full |
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