Human cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responses.

Human cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responses.

Human cytomegalovirus (HCMV) US6 glycoprotein inhibits TAP function, resulting in down-regulation of MHC class I molecules at the cell surface. Cells lacking MHC class I molecules are susceptible to NK cell lysis. HCMV expresses UL18, a MHC class I homolog that functions as a surrogate to prevent ho...

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Bibliographic Details
Main Authors:	Youngkyun Kim, Boyoun Park, Sunglim Cho, Jinwook Shin, Kwangmin Cho, Youngsoo Jun, Kwangseog Ahn
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-01-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC2483941?pdf=render

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