The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients
ASAP3 is involved in a variety of biological activities, including cancer progression in humans. In adult glioma, we explore the effects of ASAP3 and NOTCH3 and their relationships on prognosis. The Oncomine, TIMER, and Gene Expression Profiling Interactive Analysis databases were used to investigat...
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-10-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2022-0585 |
| _version_ | 1811246854463029248 |
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| author | Su Li-ping Ji Min Liu Li Sang Wei Xue Jing Wang Bo Pu Hong-Wei Zhang Wei |
| author_facet | Su Li-ping Ji Min Liu Li Sang Wei Xue Jing Wang Bo Pu Hong-Wei Zhang Wei |
| author_sort | Su Li-ping |
| collection | DOAJ |
| description | ASAP3 is involved in a variety of biological activities, including cancer progression in humans. In adult glioma, we explore the effects of ASAP3 and NOTCH3 and their relationships on prognosis. The Oncomine, TIMER, and Gene Expression Profiling Interactive Analysis databases were used to investigate ASAP3 expression. Immunohistochemistry was used to assess the levels of ASAP3 and NOTCH3 expressions. The effects of ASAP3 and NOTCH3 on prognosis were assessed using survival analysis. The results revealed that the amount of ASAP3 mRNA in gliomas was much higher than in normal tissue (P < 0.01). Glioma patients with high ASAP3 mRNA expression had a worse overall survival and progression-free survival. ASAP3 overexpression is directly associated with the NOTCH signaling system. Immunohistochemistry revealed that ASAP3 and NOTCH3 were overexpressed in glioblastomas (GBMs). ASAP3 expression was associated with age, recurrence, tumor resection, postoperative chemoradiotherapy, World Health Organization (WHO) grade, and Ki-67 expression. ASAP3 expression was related to the isocitrate dehydrogenase-1 mutation in low-grade glioma. Gender, local recurrence, tumor resection, postoperative radio-chemotherapy, WHO grade, recurrence, and ATRX expression were all associated with NOTCH3 expression. ASAP3 was shown to be positively associated with NOTCH3 (r = 0.337, P = 0.000). Therefore, ASAP3 and NOTCH3 as oncogene factors have the potential to be prognostic biomarkers and therapeutic targets in adult glioma. |
| first_indexed | 2024-04-12T14:59:21Z |
| format | Article |
| id | doaj.art-da87143e3b004b698f1cbc62b3ebc521 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T14:59:21Z |
| publishDate | 2022-10-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-da87143e3b004b698f1cbc62b3ebc5212022-12-22T03:28:07ZengDe GruyterOpen Medicine2391-54632022-10-011711724174110.1515/med-2022-0585The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patientsSu Li-ping0Ji Min1Liu Li2Sang Wei3Xue Jing4Wang Bo5Pu Hong-Wei6Zhang Wei7Department of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. ChinaCollege of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. ChinaDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. ChinaDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. ChinaDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. ChinaDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. ChinaDepartment of Science and Research Education Center, The First Affiliated Hospital, Xinjiang Medical University, No. 137 Liyushan Southern Road, Urumqi, Xinjiang 830011, P.R. ChinaDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, No. 137 Liyushan Southern Road, Urumqi, Xinjiang 830011, P.R. ChinaASAP3 is involved in a variety of biological activities, including cancer progression in humans. In adult glioma, we explore the effects of ASAP3 and NOTCH3 and their relationships on prognosis. The Oncomine, TIMER, and Gene Expression Profiling Interactive Analysis databases were used to investigate ASAP3 expression. Immunohistochemistry was used to assess the levels of ASAP3 and NOTCH3 expressions. The effects of ASAP3 and NOTCH3 on prognosis were assessed using survival analysis. The results revealed that the amount of ASAP3 mRNA in gliomas was much higher than in normal tissue (P < 0.01). Glioma patients with high ASAP3 mRNA expression had a worse overall survival and progression-free survival. ASAP3 overexpression is directly associated with the NOTCH signaling system. Immunohistochemistry revealed that ASAP3 and NOTCH3 were overexpressed in glioblastomas (GBMs). ASAP3 expression was associated with age, recurrence, tumor resection, postoperative chemoradiotherapy, World Health Organization (WHO) grade, and Ki-67 expression. ASAP3 expression was related to the isocitrate dehydrogenase-1 mutation in low-grade glioma. Gender, local recurrence, tumor resection, postoperative radio-chemotherapy, WHO grade, recurrence, and ATRX expression were all associated with NOTCH3 expression. ASAP3 was shown to be positively associated with NOTCH3 (r = 0.337, P = 0.000). Therefore, ASAP3 and NOTCH3 as oncogene factors have the potential to be prognostic biomarkers and therapeutic targets in adult glioma.https://doi.org/10.1515/med-2022-0585gliomabioinformaticsclinicopathologic characteristicsasap3notch3 |
| spellingShingle | Su Li-ping Ji Min Liu Li Sang Wei Xue Jing Wang Bo Pu Hong-Wei Zhang Wei The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients Open Medicine glioma bioinformatics clinicopathologic characteristics asap3 notch3 |
| title | The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients |
| title_full | The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients |
| title_fullStr | The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients |
| title_full_unstemmed | The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients |
| title_short | The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients |
| title_sort | expression of asap3 and notch3 and the clinicopathological characteristics of adult glioma patients |
| topic | glioma bioinformatics clinicopathologic characteristics asap3 notch3 |
| url | https://doi.org/10.1515/med-2022-0585 |
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