An integrative epi-transcriptomic approach identifies the human cartilage chitinase 3-like protein 2 (CHI3L2) as a potential mediator of B12 deficiency in adipocytes

An integrative epi-transcriptomic approach identifies the human cartilage chitinase 3-like protein 2 (CHI3L2) as a potential mediator of B12 deficiency in adipocytes

Vitamin B12 has multiple biochemical functions including in the one-carbon cycle generating a methyl group for DNA methylation, and metabolism of fatty acids and amino acids to generate energy via the citric acid cycle. The aim of our study was to use a combined epigenomic and transcriptomic approac...

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Bibliographic Details
Main Authors: B. William Ogunkolade, Antonysunil Adaikalakoteswari, Shirleny Romualdo Cardoso, Rob Lowe, Nisha Patel, Vardhman Rakyan, Sarah Finer, Martin Wabitsch, Ponnusamy Saravanan, Gyanendra Tripathi, Elena Bochukova, Graham A Hitman
Format: Article
Language:English
Published: Taylor & Francis Group 2022-10-01
Series:Epigenetics
Subjects:
vitamin b12
adipocyte
epigenome
transcriptome
chi3l2
Online Access:http://dx.doi.org/10.1080/15592294.2021.2003043

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