Cell migration in the postnatal subventricular zone
New neurons are constantly added to the olfactory bulb of rodents from birth to adulthood. This accretion is not only dependent on sustained neurogenesis, but also on the migration of neuroblasts and immature neurons from the cortical and striatal subventricular zone (SVZ) to the olfactory bulb. Mig...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2002-12-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001200002 |
| _version_ | 1818571305760325632 |
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| author | J.R.L. Menezes M. Marins J.A.J. Alves M.M. Fróes C. Hedin-Pereira |
| author_facet | J.R.L. Menezes M. Marins J.A.J. Alves M.M. Fróes C. Hedin-Pereira |
| author_sort | J.R.L. Menezes |
| collection | DOAJ |
| description | New neurons are constantly added to the olfactory bulb of rodents from birth to adulthood. This accretion is not only dependent on sustained neurogenesis, but also on the migration of neuroblasts and immature neurons from the cortical and striatal subventricular zone (SVZ) to the olfactory bulb. Migration along this long tangential pathway, known as the rostral migratory stream (RMS), is in many ways opposite to the classical radial migration of immature neurons: it is faster, spans a longer distance, does not require radial glial guidance, and is not limited to postmitotic neurons. In recent years many molecules have been found to be expressed specifically in this pathway and to directly affect this migration. Soluble factors with inhibitory, attractive and inductive roles in migration have been described, as well as molecules mediating cell-to-cell and cell-substrate interactions. However, it is still unclear how the various molecules and cells interact to account for the special migratory behavior in the RMS. Here we will propose some candidate mechanisms for roles in initiating and stopping SVZ/RMS migration. |
| first_indexed | 2024-12-14T13:53:58Z |
| format | Article |
| id | doaj.art-da879ce0727f4436867d679699e5d4ba |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-14T13:53:58Z |
| publishDate | 2002-12-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-da879ce0727f4436867d679699e5d4ba2022-12-21T22:58:55ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2002-12-0135121411142110.1590/S0100-879X2002001200002Cell migration in the postnatal subventricular zoneJ.R.L. MenezesM. MarinsJ.A.J. AlvesM.M. FróesC. Hedin-PereiraNew neurons are constantly added to the olfactory bulb of rodents from birth to adulthood. This accretion is not only dependent on sustained neurogenesis, but also on the migration of neuroblasts and immature neurons from the cortical and striatal subventricular zone (SVZ) to the olfactory bulb. Migration along this long tangential pathway, known as the rostral migratory stream (RMS), is in many ways opposite to the classical radial migration of immature neurons: it is faster, spans a longer distance, does not require radial glial guidance, and is not limited to postmitotic neurons. In recent years many molecules have been found to be expressed specifically in this pathway and to directly affect this migration. Soluble factors with inhibitory, attractive and inductive roles in migration have been described, as well as molecules mediating cell-to-cell and cell-substrate interactions. However, it is still unclear how the various molecules and cells interact to account for the special migratory behavior in the RMS. Here we will propose some candidate mechanisms for roles in initiating and stopping SVZ/RMS migration.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001200002Postnatal neurogenesisChain migrationRostral migratory streamAstrocytesGap junctionsRadial glia |
| spellingShingle | J.R.L. Menezes M. Marins J.A.J. Alves M.M. Fróes C. Hedin-Pereira Cell migration in the postnatal subventricular zone Brazilian Journal of Medical and Biological Research Postnatal neurogenesis Chain migration Rostral migratory stream Astrocytes Gap junctions Radial glia |
| title | Cell migration in the postnatal subventricular zone |
| title_full | Cell migration in the postnatal subventricular zone |
| title_fullStr | Cell migration in the postnatal subventricular zone |
| title_full_unstemmed | Cell migration in the postnatal subventricular zone |
| title_short | Cell migration in the postnatal subventricular zone |
| title_sort | cell migration in the postnatal subventricular zone |
| topic | Postnatal neurogenesis Chain migration Rostral migratory stream Astrocytes Gap junctions Radial glia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001200002 |
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