Atractylenolide-1 Targets FLT3 to Regulate PI3K/AKT/HIF1-α Pathway to Inhibit Osteogenic Differentiation of Human Valve Interstitial Cells

Atractylenolide-1 Targets FLT3 to Regulate PI3K/AKT/HIF1-α Pathway to Inhibit Osteogenic Differentiation of Human Valve Interstitial Cells

Atractylenolide-1 (AT-1), a natural active ingredient extracted from Atractylodes macrocephala, was reported to have good anti-fibrotic and anti-inflammatory effects. Osteogenic changes induced by the inflammation of valve interstitial cells (VICs) play a role in the development of calcified aortic...

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Bibliographic Details
Main Authors: Jie Wang, Penghua Zhang, Jing Zhang, Zhaohui Ma, Xingqin Tian, Yan Liu, Guanghui Lv, Linghang Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
Atractylenolide-1
calcification
PI3K
FLT3
HIF1-α
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.899775/full

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