Overexpression of CMTM7 inhibits cell growth and migration in liver cancer
Abstract Chemokine‐like factor (CKLF)‐like, MAL and related proteins for vesicle trafficking and membrane link (MARVEL) transmembrane domain‐containing family proteins (CMTMs) have significant roles in the immune system, in male reproduction, as well as in tumorigenesis. Previous studies have shown...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-06-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/kjm2.12058 |
| _version_ | 1818764744826290176 |
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| author | Zi‐Ming Huang Peng‐Ling Li Peng Yang Xiao‐Dan Hou Yi‐Li Yang Xin Xu Feng Xu |
| author_facet | Zi‐Ming Huang Peng‐Ling Li Peng Yang Xiao‐Dan Hou Yi‐Li Yang Xin Xu Feng Xu |
| author_sort | Zi‐Ming Huang |
| collection | DOAJ |
| description | Abstract Chemokine‐like factor (CKLF)‐like, MAL and related proteins for vesicle trafficking and membrane link (MARVEL) transmembrane domain‐containing family proteins (CMTMs) have significant roles in the immune system, in male reproduction, as well as in tumorigenesis. Previous studies have shown that CMTM family member 7 (CMTM7) was broadly expressed in various normal tissues, but not in lung, gastric, esophageal, pancreas, and cervix cancers. To explore its relationship with liver cancer, we examined the expression of CMTM7 in liver cancers and its correlation with clinical and pathological conditions. We found that CMTM7 expression was markedly reduced in liver cancer tissues, and negatively correlated with TNM staging and tumor metastasis. In vitro studies showed that enforced expression of CMTM7 inhibited the cell growth and migration of liver cancer cells. Further analysis revealed that CMTM7 suppressed AKT signaling and induced cell cycle arrest at the G0/G1 phase in the liver cancer cells, likely as the consequent of decreased levels of cyclin D1, cyclin‐dependent kinase 4 (CDK4), and CDK6, and increased p27 expression. Thus, CMTM7 functions as a tumor suppressor in liver cancer through suppressing cell cycle progression. |
| first_indexed | 2024-12-18T08:07:04Z |
| format | Article |
| id | doaj.art-da8a31a2b6c04c589cb173ed39b74f45 |
| institution | Directory Open Access Journal |
| issn | 1607-551X 2410-8650 |
| language | English |
| last_indexed | 2024-12-18T08:07:04Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-da8a31a2b6c04c589cb173ed39b74f452022-12-21T21:14:59ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502019-06-0135633234010.1002/kjm2.12058Overexpression of CMTM7 inhibits cell growth and migration in liver cancerZi‐Ming Huang0Peng‐Ling Li1Peng Yang2Xiao‐Dan Hou3Yi‐Li Yang4Xin Xu5Feng Xu6Department of Emergency Surgery The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Respiratory Care The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University Huai'an Jiangsu ChinaDepartment of Emergency Surgery The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaSuzhou Institute of Systems Medicine Center for Systems Medicine, Chinese Academy of Medical Sciences Suzhou Jiangsu ChinaSuzhou Institute of Systems Medicine Center for Systems Medicine, Chinese Academy of Medical Sciences Suzhou Jiangsu ChinaSuzhou Institute of Systems Medicine Center for Systems Medicine, Chinese Academy of Medical Sciences Suzhou Jiangsu ChinaDepartment of Emergency Surgery The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaAbstract Chemokine‐like factor (CKLF)‐like, MAL and related proteins for vesicle trafficking and membrane link (MARVEL) transmembrane domain‐containing family proteins (CMTMs) have significant roles in the immune system, in male reproduction, as well as in tumorigenesis. Previous studies have shown that CMTM family member 7 (CMTM7) was broadly expressed in various normal tissues, but not in lung, gastric, esophageal, pancreas, and cervix cancers. To explore its relationship with liver cancer, we examined the expression of CMTM7 in liver cancers and its correlation with clinical and pathological conditions. We found that CMTM7 expression was markedly reduced in liver cancer tissues, and negatively correlated with TNM staging and tumor metastasis. In vitro studies showed that enforced expression of CMTM7 inhibited the cell growth and migration of liver cancer cells. Further analysis revealed that CMTM7 suppressed AKT signaling and induced cell cycle arrest at the G0/G1 phase in the liver cancer cells, likely as the consequent of decreased levels of cyclin D1, cyclin‐dependent kinase 4 (CDK4), and CDK6, and increased p27 expression. Thus, CMTM7 functions as a tumor suppressor in liver cancer through suppressing cell cycle progression.https://doi.org/10.1002/kjm2.12058cell cyclecell growthCMTM7liver cancermigration |
| spellingShingle | Zi‐Ming Huang Peng‐Ling Li Peng Yang Xiao‐Dan Hou Yi‐Li Yang Xin Xu Feng Xu Overexpression of CMTM7 inhibits cell growth and migration in liver cancer Kaohsiung Journal of Medical Sciences cell cycle cell growth CMTM7 liver cancer migration |
| title | Overexpression of CMTM7 inhibits cell growth and migration in liver cancer |
| title_full | Overexpression of CMTM7 inhibits cell growth and migration in liver cancer |
| title_fullStr | Overexpression of CMTM7 inhibits cell growth and migration in liver cancer |
| title_full_unstemmed | Overexpression of CMTM7 inhibits cell growth and migration in liver cancer |
| title_short | Overexpression of CMTM7 inhibits cell growth and migration in liver cancer |
| title_sort | overexpression of cmtm7 inhibits cell growth and migration in liver cancer |
| topic | cell cycle cell growth CMTM7 liver cancer migration |
| url | https://doi.org/10.1002/kjm2.12058 |
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