Influence of preoperative intravitreal injection of Ranibizumab on perioperative VRS parameters in patients with PDR
AIM: To discuss the effects of preoperative vitreous cavity injection of ranibizumab on 25G minimally invasive vitreoretinal surgery(VRS)in patients with proliferative diabetic retinopathy(PDR).<p>METHODS: From February 2013 to December 2015, 74 patients with PDR received VRS(82 eyes)were retr...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2017-08-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2017/8/201708044.pdf |
| _version_ | 1811255437557760000 |
|---|---|
| author | Jun-Xia Lu Su-Hua Li Hua Tian |
| author_facet | Jun-Xia Lu Su-Hua Li Hua Tian |
| author_sort | Jun-Xia Lu |
| collection | DOAJ |
| description | AIM: To discuss the effects of preoperative vitreous cavity injection of ranibizumab on 25G minimally invasive vitreoretinal surgery(VRS)in patients with proliferative diabetic retinopathy(PDR).<p>METHODS: From February 2013 to December 2015, 74 patients with PDR received VRS(82 eyes)were retrospectively analyzed. Patients were divided into VRS + IVR group and VRS group according to preoperative VRS treatment. VRS+IVR group: preoperative injection of ranibizumab(10mg / mL)at 3-5d before operation; VRS group: VRS only. We recorded VRS operation time, filling situation, iatrogenic retinal hole and so on. <p>RESULTS: The operation time and coagulation times of VRS+IVR group were significantly lower than VRS group. The two groups in operation time and coagulation times were statistically significant(all <i>P</i><0.05). In the VRS+IVR group, the number of cases of iatrogenic retinal hole and the use of silicone oil were lower than those of VRS group, the difference between the two groups was statistically significant(<i>P</i><0.05). While the use number of C<sub>3</sub>F<sub>8</sub> and perfusion fluid were not statistically significant(<i>P</i>>0.05). In VRS-IVR group within 3mo after operation, 4 eyes appeared to vitreous body hematocele, VRS group was 13 eyes, the difference was statistically significant(<i>χ</i><sup>2</sup>=4.966, <i>P</i><0.05). <p>CONCLUSION: PDR patients with 25G minimally invasive VRS with preoperative therapy can reduce postoperative ocular bleeding, rate of retinal injury and silicone oil filling, shorten the operation time, the incidence rate and improve the success rate of surgery and reduce eye bleeding, postoperative complications such as adhesion. |
| first_indexed | 2024-04-12T17:24:54Z |
| format | Article |
| id | doaj.art-da8a5b879e4840db82d0d359a7c0ef08 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-04-12T17:24:54Z |
| publishDate | 2017-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-da8a5b879e4840db82d0d359a7c0ef082022-12-22T03:23:21ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232017-08-011781569157110.3980/j.issn.1672-5123.2017.8.44Influence of preoperative intravitreal injection of Ranibizumab on perioperative VRS parameters in patients with PDRJun-Xia Lu0Su-Hua Li1Hua Tian2Nanyang City Center Hospital; Affiliated Hospital of Zhengzhou University, Nanyang 473000, Henan Province, ChinaNanyang City Center Hospital; Affiliated Hospital of Zhengzhou University, Nanyang 473000, Henan Province, ChinaNanyang City Center Hospital; Affiliated Hospital of Zhengzhou University, Nanyang 473000, Henan Province, ChinaAIM: To discuss the effects of preoperative vitreous cavity injection of ranibizumab on 25G minimally invasive vitreoretinal surgery(VRS)in patients with proliferative diabetic retinopathy(PDR).<p>METHODS: From February 2013 to December 2015, 74 patients with PDR received VRS(82 eyes)were retrospectively analyzed. Patients were divided into VRS + IVR group and VRS group according to preoperative VRS treatment. VRS+IVR group: preoperative injection of ranibizumab(10mg / mL)at 3-5d before operation; VRS group: VRS only. We recorded VRS operation time, filling situation, iatrogenic retinal hole and so on. <p>RESULTS: The operation time and coagulation times of VRS+IVR group were significantly lower than VRS group. The two groups in operation time and coagulation times were statistically significant(all <i>P</i><0.05). In the VRS+IVR group, the number of cases of iatrogenic retinal hole and the use of silicone oil were lower than those of VRS group, the difference between the two groups was statistically significant(<i>P</i><0.05). While the use number of C<sub>3</sub>F<sub>8</sub> and perfusion fluid were not statistically significant(<i>P</i>>0.05). In VRS-IVR group within 3mo after operation, 4 eyes appeared to vitreous body hematocele, VRS group was 13 eyes, the difference was statistically significant(<i>χ</i><sup>2</sup>=4.966, <i>P</i><0.05). <p>CONCLUSION: PDR patients with 25G minimally invasive VRS with preoperative therapy can reduce postoperative ocular bleeding, rate of retinal injury and silicone oil filling, shorten the operation time, the incidence rate and improve the success rate of surgery and reduce eye bleeding, postoperative complications such as adhesion.http://ies.ijo.cn/cn_publish/2017/8/201708044.pdfproliferative diabetic retinopathyvitreoretinal surgeryranibizumabvitreous resuscitationvitreous resuscitation |
| spellingShingle | Jun-Xia Lu Su-Hua Li Hua Tian Influence of preoperative intravitreal injection of Ranibizumab on perioperative VRS parameters in patients with PDR Guoji Yanke Zazhi proliferative diabetic retinopathy vitreoretinal surgery ranibizumab vitreous resuscitation vitreous resuscitation |
| title | Influence of preoperative intravitreal injection of Ranibizumab on perioperative VRS parameters in patients with PDR |
| title_full | Influence of preoperative intravitreal injection of Ranibizumab on perioperative VRS parameters in patients with PDR |
| title_fullStr | Influence of preoperative intravitreal injection of Ranibizumab on perioperative VRS parameters in patients with PDR |
| title_full_unstemmed | Influence of preoperative intravitreal injection of Ranibizumab on perioperative VRS parameters in patients with PDR |
| title_short | Influence of preoperative intravitreal injection of Ranibizumab on perioperative VRS parameters in patients with PDR |
| title_sort | influence of preoperative intravitreal injection of ranibizumab on perioperative vrs parameters in patients with pdr |
| topic | proliferative diabetic retinopathy vitreoretinal surgery ranibizumab vitreous resuscitation vitreous resuscitation |
| url | http://ies.ijo.cn/cn_publish/2017/8/201708044.pdf |
| work_keys_str_mv | AT junxialu influenceofpreoperativeintravitrealinjectionofranibizumabonperioperativevrsparametersinpatientswithpdr AT suhuali influenceofpreoperativeintravitrealinjectionofranibizumabonperioperativevrsparametersinpatientswithpdr AT huatian influenceofpreoperativeintravitrealinjectionofranibizumabonperioperativevrsparametersinpatientswithpdr |