The Interrelation between Interleukin-2 and Schizophrenia
Interleukin-2 (IL-2) is a growth factor that regulates T-cell autocrine secretion and has long been considered to be closely related to immune response. With the advance in neuroinflammation theory and immunology research on schizophrenia, it is interesting and meaningful to discuss the possible rol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/9/1154 |
| _version_ | 1797490566489964544 |
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| author | Yu Huang Xin Zhang Na Zhou |
| author_facet | Yu Huang Xin Zhang Na Zhou |
| author_sort | Yu Huang |
| collection | DOAJ |
| description | Interleukin-2 (IL-2) is a growth factor that regulates T-cell autocrine secretion and has long been considered to be closely related to immune response. With the advance in neuroinflammation theory and immunology research on schizophrenia, it is interesting and meaningful to discuss the possible role of IL-2 in schizophrenia. Here, we reviewed a series of studies published from the 1990s and found that IL-2 was closely associated with schizophrenia. For example, IL-2 is responsible for mediating toxic reactions, which are the causes of schizophrenia symptoms in patients, and such symptoms resolve after discontinuation of the drug. In addition, we focused on the changes of IL-2 in the onset, progression and treatment of schizophrenia and the possible mechanisms by which IL-2 affects schizophrenia. Our review suggests that IL-2 is associated with schizophrenia and plays a role in its pathogenesis, and progression IL-2 and sIL-2R could serve as potential biomarkers of schizophrenia. |
| first_indexed | 2024-03-10T00:34:50Z |
| format | Article |
| id | doaj.art-da8a8647ca484315b13d57baa7e83b9f |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T00:34:50Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-da8a8647ca484315b13d57baa7e83b9f2023-11-23T15:20:06ZengMDPI AGBrain Sciences2076-34252022-08-01129115410.3390/brainsci12091154The Interrelation between Interleukin-2 and SchizophreniaYu Huang0Xin Zhang1Na Zhou2School of Pharmacy, Macau University of Science and Technology, Macau 999078, ChinaSchool of Pharmacy, Macau University of Science and Technology, Macau 999078, ChinaSchool of Pharmacy, Macau University of Science and Technology, Macau 999078, ChinaInterleukin-2 (IL-2) is a growth factor that regulates T-cell autocrine secretion and has long been considered to be closely related to immune response. With the advance in neuroinflammation theory and immunology research on schizophrenia, it is interesting and meaningful to discuss the possible role of IL-2 in schizophrenia. Here, we reviewed a series of studies published from the 1990s and found that IL-2 was closely associated with schizophrenia. For example, IL-2 is responsible for mediating toxic reactions, which are the causes of schizophrenia symptoms in patients, and such symptoms resolve after discontinuation of the drug. In addition, we focused on the changes of IL-2 in the onset, progression and treatment of schizophrenia and the possible mechanisms by which IL-2 affects schizophrenia. Our review suggests that IL-2 is associated with schizophrenia and plays a role in its pathogenesis, and progression IL-2 and sIL-2R could serve as potential biomarkers of schizophrenia.https://www.mdpi.com/2076-3425/12/9/1154schizophreniainterleukin-2immune responseneuroinflammation biomarker |
| spellingShingle | Yu Huang Xin Zhang Na Zhou The Interrelation between Interleukin-2 and Schizophrenia Brain Sciences schizophrenia interleukin-2 immune response neuroinflammation biomarker |
| title | The Interrelation between Interleukin-2 and Schizophrenia |
| title_full | The Interrelation between Interleukin-2 and Schizophrenia |
| title_fullStr | The Interrelation between Interleukin-2 and Schizophrenia |
| title_full_unstemmed | The Interrelation between Interleukin-2 and Schizophrenia |
| title_short | The Interrelation between Interleukin-2 and Schizophrenia |
| title_sort | interrelation between interleukin 2 and schizophrenia |
| topic | schizophrenia interleukin-2 immune response neuroinflammation biomarker |
| url | https://www.mdpi.com/2076-3425/12/9/1154 |
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