Advances of Immunotherapy Resistance and Coping Strategies in Non-small Cell Lung Cancer
Immunotherapy has significantly improved clinical outcomes of non-small cell lung cancer (NSCLC), however, along with the popularization of immunotherapy, immune resistance has become an unavoidable problem. Immunotherapy can induce extensive cellular and molecular alterations in the tumor microenvi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2023-01-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2023.102.03 |
| _version_ | 1828014728505458688 |
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| author | Yawan JING Hao ZENG Ruixin CHENG Panwen TIAN Yalun LI |
| author_facet | Yawan JING Hao ZENG Ruixin CHENG Panwen TIAN Yalun LI |
| author_sort | Yawan JING |
| collection | DOAJ |
| description | Immunotherapy has significantly improved clinical outcomes of non-small cell lung cancer (NSCLC), however, along with the popularization of immunotherapy, immune resistance has become an unavoidable problem. Immunotherapy can induce extensive cellular and molecular alterations in the tumor microenvironment. Considering the mechanisms of immune resistance are not yet fully understood and the efficacy of standard chemotherapy regimens is limited, more effective coping strategies based on resistance mechanisms are urgently needed. In this review, we intend to summarize the known mechanisms of immune resistance and feasible strategies, so as to provide a foundation for clinicians to develop more individualized and precise regimens and finally improve patients’ prognosis. |
| first_indexed | 2024-04-10T10:06:10Z |
| format | Article |
| id | doaj.art-da8b35317bbe4f0eb8872a55c16facc4 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-10T10:06:10Z |
| publishDate | 2023-01-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-da8b35317bbe4f0eb8872a55c16facc42023-02-16T00:55:34ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872023-01-01261667710.3779/j.issn.1009-3419.2023.102.03Advances of Immunotherapy Resistance and Coping Strategies
in Non-small Cell Lung CancerYawan JING0Hao ZENG1Ruixin CHENG2Panwen TIAN3Yalun LI4Department of Respiratory and Critical Care Medicine, West China Hospital, Chengdu 610041, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital, Chengdu 610041, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital, Chengdu 610041, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital, Chengdu 610041, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital, Chengdu 610041, ChinaImmunotherapy has significantly improved clinical outcomes of non-small cell lung cancer (NSCLC), however, along with the popularization of immunotherapy, immune resistance has become an unavoidable problem. Immunotherapy can induce extensive cellular and molecular alterations in the tumor microenvironment. Considering the mechanisms of immune resistance are not yet fully understood and the efficacy of standard chemotherapy regimens is limited, more effective coping strategies based on resistance mechanisms are urgently needed. In this review, we intend to summarize the known mechanisms of immune resistance and feasible strategies, so as to provide a foundation for clinicians to develop more individualized and precise regimens and finally improve patients’ prognosis.http://dx.doi.org/10.3779/j.issn.1009-3419.2023.102.03immunotherapyimmunoresistancelung neoplasmscoping strategies |
| spellingShingle | Yawan JING Hao ZENG Ruixin CHENG Panwen TIAN Yalun LI Advances of Immunotherapy Resistance and Coping Strategies in Non-small Cell Lung Cancer Chinese Journal of Lung Cancer immunotherapy immunoresistance lung neoplasms coping strategies |
| title | Advances of Immunotherapy Resistance and Coping Strategies
in Non-small Cell Lung Cancer |
| title_full | Advances of Immunotherapy Resistance and Coping Strategies
in Non-small Cell Lung Cancer |
| title_fullStr | Advances of Immunotherapy Resistance and Coping Strategies
in Non-small Cell Lung Cancer |
| title_full_unstemmed | Advances of Immunotherapy Resistance and Coping Strategies
in Non-small Cell Lung Cancer |
| title_short | Advances of Immunotherapy Resistance and Coping Strategies
in Non-small Cell Lung Cancer |
| title_sort | advances of immunotherapy resistance and coping strategies
in non small cell lung cancer |
| topic | immunotherapy immunoresistance lung neoplasms coping strategies |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2023.102.03 |
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