Trimetazidine effects on heart and kidney functional status, and quality of life in long-term complex treatment of chronic heart failure in elderly patients
Aim. To study trimetazidine influence, as a part of complex long-term treatment of chronic heart failure (CHF), on functional heart and kidney status, as well as on quality of life (QoL) in elderly CHF patients. Material and methods. Forty patients with clinically manifested CHF, functional class (F...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2005-10-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1005 |
| Summary: | Aim. To study trimetazidine influence, as a part of complex long-term treatment of chronic heart failure (CHF), on functional heart and kidney status, as well as on quality of life (QoL) in elderly CHF patients. Material and methods. Forty patients with clinically manifested CHF, functional class (FC) II-III, and myocardial infarction (MI) in anamnesis were randomized into two groups. Group I (n=20) received basic CHF therapy and trimetazidine (70 mg/d), Group II (n=20) - basal therapy only. Follow-up period lasted for 12 months. At baseline, 12 weeks later, and after the treatment, QoL was assessed by Minnesota Questionnaire, 6-minute walking test and echocardiography (EchoCG) were performed, CHF FC and functional kidney status were assessed. Results. Additional trimetazidine therapy was associated with significant decrease in local myocardial contractility (LMC) index by the end of follow-up, comparing with Group II (0.9±0.34 vs 2.8±0.89, р<0.05). In Group I, CHF FC decreased more substantially, QoL, heart diastolic function and renal function were improved. Conclusion. Adding trimetazidine to standard CHF therapy improved workload tolerance, QoL, systolic and diastolic heart function, LMC, and demonstrated additional nephroprotective effect in the elderly CHF patients. |
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| ISSN: | 1728-8800 2619-0125 |