Serum activity of Angiotensin converting enzyme and blood pressure response to acute dynamic exercise
Angiotensin converting enzyme (ACE) plays an important role in blood pressure regulation not only in the state of rest, but also during physical exercise. The aim of this study was to estimate the serum ACE activity in response to acute dynamic exercise. The study involved a group of young, healthy...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2004-11-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3357 |
| _version_ | 1797260783263940608 |
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| author | Emina Nakać-Ićindić Adnan Hadžimuratović Jasminko Huskić Almira Hadžović Asija Začiragić Nešina Avdagić |
| author_facet | Emina Nakać-Ićindić Adnan Hadžimuratović Jasminko Huskić Almira Hadžović Asija Začiragić Nešina Avdagić |
| author_sort | Emina Nakać-Ićindić |
| collection | DOAJ |
| description |
Angiotensin converting enzyme (ACE) plays an important role in blood pressure regulation not only in the state of rest, but also during physical exercise. The aim of this study was to estimate the serum ACE activity in response to acute dynamic exercise. The study involved a group of young, healthy, male volunteers (average 22 years of age). Exercise testing was carried out on ergometer bicycle according to the protocol of individually adjusted continuous, constant workload (3 W/kg). The activity of ACE in serum was measured in venous blood, in the period of rest, in 4th, 8th and 12th minute of exercise and 1st, 3rd and 6th minute of recovery by spectrophotometric method. Marked inter-individual differences in basal serum ACE activity were determined (range 8, 31-63, 72 U/L). Serum ACE activity did not significantly vary during exercise and in the period of recovery. Systolic blood pressure changed during exercise compared to values during rest period in accordance with the applied type of dynamical exercise. Diastolic blood pressure did not vary considerably during exercise. Statistically significant correlation between mean arterial blood pressure and ACE activity in the serum was not found. The lack of increase of ACE activity in the serum, in spite of changes in blood pressure values, most likely shows the presence of alternative ACE independent pathway involved in the production of vasoactive substances that have important role in the regulation of cardiovascular system response to acutedynamic exercise.
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| first_indexed | 2024-04-24T23:30:48Z |
| format | Article |
| id | doaj.art-da8d7876a8264220a0ec022eec0b5b66 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:30:48Z |
| publishDate | 2004-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-da8d7876a8264220a0ec022eec0b5b662024-03-15T14:43:59ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2004-11-014410.17305/bjbms.2004.3357807Serum activity of Angiotensin converting enzyme and blood pressure response to acute dynamic exerciseEmina Nakać-Ićindić0Adnan Hadžimuratović1Jasminko Huskić2Almira Hadžović3Asija Začiragić4Nešina Avdagić5Institute of Physiology and Biochemistry, School of Medicine, University of SarajevoChildren Surgery Department, Sarajevo University Clinics CentreInstitute of Physiology and Biochemistry, School of Medicine, University of SarajevoInstitute of Physiology and Biochemistry, School of Medicine, University of SarajevoInstitute of Physiology and Biochemistry, School of Medicine, University of SarajevoInstitute of Physiology and Biochemistry, School of Medicine, University of Sarajevo Angiotensin converting enzyme (ACE) plays an important role in blood pressure regulation not only in the state of rest, but also during physical exercise. The aim of this study was to estimate the serum ACE activity in response to acute dynamic exercise. The study involved a group of young, healthy, male volunteers (average 22 years of age). Exercise testing was carried out on ergometer bicycle according to the protocol of individually adjusted continuous, constant workload (3 W/kg). The activity of ACE in serum was measured in venous blood, in the period of rest, in 4th, 8th and 12th minute of exercise and 1st, 3rd and 6th minute of recovery by spectrophotometric method. Marked inter-individual differences in basal serum ACE activity were determined (range 8, 31-63, 72 U/L). Serum ACE activity did not significantly vary during exercise and in the period of recovery. Systolic blood pressure changed during exercise compared to values during rest period in accordance with the applied type of dynamical exercise. Diastolic blood pressure did not vary considerably during exercise. Statistically significant correlation between mean arterial blood pressure and ACE activity in the serum was not found. The lack of increase of ACE activity in the serum, in spite of changes in blood pressure values, most likely shows the presence of alternative ACE independent pathway involved in the production of vasoactive substances that have important role in the regulation of cardiovascular system response to acutedynamic exercise. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3357angiotensin converting enzymeacute exercisehealthy volunteersmale |
| spellingShingle | Emina Nakać-Ićindić Adnan Hadžimuratović Jasminko Huskić Almira Hadžović Asija Začiragić Nešina Avdagić Serum activity of Angiotensin converting enzyme and blood pressure response to acute dynamic exercise Biomolecules & Biomedicine angiotensin converting enzyme acute exercise healthy volunteers male |
| title | Serum activity of Angiotensin converting enzyme and blood pressure response to acute dynamic exercise |
| title_full | Serum activity of Angiotensin converting enzyme and blood pressure response to acute dynamic exercise |
| title_fullStr | Serum activity of Angiotensin converting enzyme and blood pressure response to acute dynamic exercise |
| title_full_unstemmed | Serum activity of Angiotensin converting enzyme and blood pressure response to acute dynamic exercise |
| title_short | Serum activity of Angiotensin converting enzyme and blood pressure response to acute dynamic exercise |
| title_sort | serum activity of angiotensin converting enzyme and blood pressure response to acute dynamic exercise |
| topic | angiotensin converting enzyme acute exercise healthy volunteers male |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3357 |
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