Facile synthesis of mesoporous alumina using hexadecyltrimethylammonium bromide (HTAB) as template: simplified sol‐gel approach
Herein the authors present the synthesis of surface functionalised mesoporous alumina (MeAl) for textural characterisation by a simplified sol–gel method obtained by using hexadecyltrimethylammonium bromide as a template. Etoricoxib (ETOX) was used as a model drug for the study. Alumina supported me...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi-IET
2019-10-01
|
| Series: | IET Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1049/iet-nbt.2018.5343 |
| _version_ | 1797429517176799232 |
|---|---|
| author | Sameer H. Lakade Minal T. Harde Varsha Chattichalwadi Pravin S. Uttekar |
| author_facet | Sameer H. Lakade Minal T. Harde Varsha Chattichalwadi Pravin S. Uttekar |
| author_sort | Sameer H. Lakade |
| collection | DOAJ |
| description | Herein the authors present the synthesis of surface functionalised mesoporous alumina (MeAl) for textural characterisation by a simplified sol–gel method obtained by using hexadecyltrimethylammonium bromide as a template. Etoricoxib (ETOX) was used as a model drug for the study. Alumina supported mesoporous material containing drug was characterised using instrumental technique namely Brunauer–Emmett–Teller surface area, Fourier transform‐infrared, differential scanning calorimetry, transmission electron microscopy, X‐ray diffraction, and field emission scanning electron microscopy. Diffusion study using a dialysis bag method used to check the release pattern of ETOX‐loaded‐MeAl. Results of characterisation study revealed the successful surface functionalisation of the drug on nanocomposite. The IC50 value obtained from cell viability study demonstrated the non‐toxic behaviour of synthesised drug‐loaded mesoporous alumina up to the tested concentration range. The present work has demonstrated that synthesised MeAl showed excellent stability with an expanded surface area suitable for carrier material for drug delivery system. |
| first_indexed | 2024-03-09T09:14:16Z |
| format | Article |
| id | doaj.art-da8e2f0dbc1c478c8c8cd1a2100c71bf |
| institution | Directory Open Access Journal |
| issn | 1751-8741 1751-875X |
| language | English |
| last_indexed | 2024-03-09T09:14:16Z |
| publishDate | 2019-10-01 |
| publisher | Hindawi-IET |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj.art-da8e2f0dbc1c478c8c8cd1a2100c71bf2023-12-02T07:52:22ZengHindawi-IETIET Nanobiotechnology1751-87411751-875X2019-10-0113883484110.1049/iet-nbt.2018.5343Facile synthesis of mesoporous alumina using hexadecyltrimethylammonium bromide (HTAB) as template: simplified sol‐gel approachSameer H. Lakade0Minal T. Harde1Varsha Chattichalwadi2Pravin S. Uttekar3Department of PharmaceuticsRMD Institute of Pharmaceutical Education & ResearchPuneMSIndiaDepartment of Pharmaceutical ChemistryPES's Modern College of PharmacySector no. 21, Yamunanagar, NigdiPuneMSIndiaPost Graduate Department of PharmaceuticsSinhgad Institute of Pharmaceutical SciencesKus(Bk) LonavalaPuneMSIndiaDepartment of PharmaceuticsPES's Modern College of PharmacySector no. 21, Yamunanagar, NigdiPuneMSIndiaHerein the authors present the synthesis of surface functionalised mesoporous alumina (MeAl) for textural characterisation by a simplified sol–gel method obtained by using hexadecyltrimethylammonium bromide as a template. Etoricoxib (ETOX) was used as a model drug for the study. Alumina supported mesoporous material containing drug was characterised using instrumental technique namely Brunauer–Emmett–Teller surface area, Fourier transform‐infrared, differential scanning calorimetry, transmission electron microscopy, X‐ray diffraction, and field emission scanning electron microscopy. Diffusion study using a dialysis bag method used to check the release pattern of ETOX‐loaded‐MeAl. Results of characterisation study revealed the successful surface functionalisation of the drug on nanocomposite. The IC50 value obtained from cell viability study demonstrated the non‐toxic behaviour of synthesised drug‐loaded mesoporous alumina up to the tested concentration range. The present work has demonstrated that synthesised MeAl showed excellent stability with an expanded surface area suitable for carrier material for drug delivery system.https://doi.org/10.1049/iet-nbt.2018.5343ETOX‐loaded‐MeAlsuccessful surface functionalisationsynthesised drug‐loaded mesoporous aluminasynthesised MeAlexpanded surface areadrug delivery system |
| spellingShingle | Sameer H. Lakade Minal T. Harde Varsha Chattichalwadi Pravin S. Uttekar Facile synthesis of mesoporous alumina using hexadecyltrimethylammonium bromide (HTAB) as template: simplified sol‐gel approach IET Nanobiotechnology ETOX‐loaded‐MeAl successful surface functionalisation synthesised drug‐loaded mesoporous alumina synthesised MeAl expanded surface area drug delivery system |
| title | Facile synthesis of mesoporous alumina using hexadecyltrimethylammonium bromide (HTAB) as template: simplified sol‐gel approach |
| title_full | Facile synthesis of mesoporous alumina using hexadecyltrimethylammonium bromide (HTAB) as template: simplified sol‐gel approach |
| title_fullStr | Facile synthesis of mesoporous alumina using hexadecyltrimethylammonium bromide (HTAB) as template: simplified sol‐gel approach |
| title_full_unstemmed | Facile synthesis of mesoporous alumina using hexadecyltrimethylammonium bromide (HTAB) as template: simplified sol‐gel approach |
| title_short | Facile synthesis of mesoporous alumina using hexadecyltrimethylammonium bromide (HTAB) as template: simplified sol‐gel approach |
| title_sort | facile synthesis of mesoporous alumina using hexadecyltrimethylammonium bromide htab as template simplified sol gel approach |
| topic | ETOX‐loaded‐MeAl successful surface functionalisation synthesised drug‐loaded mesoporous alumina synthesised MeAl expanded surface area drug delivery system |
| url | https://doi.org/10.1049/iet-nbt.2018.5343 |
| work_keys_str_mv | AT sameerhlakade facilesynthesisofmesoporousaluminausinghexadecyltrimethylammoniumbromidehtabastemplatesimplifiedsolgelapproach AT minaltharde facilesynthesisofmesoporousaluminausinghexadecyltrimethylammoniumbromidehtabastemplatesimplifiedsolgelapproach AT varshachattichalwadi facilesynthesisofmesoporousaluminausinghexadecyltrimethylammoniumbromidehtabastemplatesimplifiedsolgelapproach AT pravinsuttekar facilesynthesisofmesoporousaluminausinghexadecyltrimethylammoniumbromidehtabastemplatesimplifiedsolgelapproach |