M1 Polarized Tumor-Associated Macrophages (TAMs) as Promising Prognostic Signature in Stage I–II Gastric Adenocarcinomas
Tumor-associated macrophages (TAMs) may be noticed in gastric carcinomas (GC), but their clinicopathological significance has not been yet explored. From a histological review of 400 cases of tubular/papillary adenocarcinomas, 24 cases of stage I–II gastric adenocarcinomas with intraglandular and st...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Gastrointestinal Disorders |
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| Online Access: | https://www.mdpi.com/2624-5647/3/4/20 |
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| author | Antonio Ieni Rosario Alberto Caruso Cristina Pizzimenti Giuseppe Giuffrè Eleonora Irato Luciana Rigoli Giuseppe Navarra Guido Fadda Giovanni Tuccari |
| author_facet | Antonio Ieni Rosario Alberto Caruso Cristina Pizzimenti Giuseppe Giuffrè Eleonora Irato Luciana Rigoli Giuseppe Navarra Guido Fadda Giovanni Tuccari |
| author_sort | Antonio Ieni |
| collection | DOAJ |
| description | Tumor-associated macrophages (TAMs) may be noticed in gastric carcinomas (GC), but their clinicopathological significance has not been yet explored. From a histological review of 400 cases of tubular/papillary adenocarcinomas, 24 cases of stage I–II gastric adenocarcinomas with intraglandular and stromal TAMs were identified. Their clinicopathological features were compared with 72 pT-matched as well as stage-matched control cases of adenocarcinomas without TAMs. TAMs present in GC cases were present either in glands or in neoplastic stroma, showing an immunoreactivity for CD68 and CD80; sometimes, they were organized in mature granulomas with occasional giant cells. Therefore, the stained TAMs were reminiscent of a specific polarized macrophage M1 phenotype; however, in any case of our cohort, no M2 phenotype macrophages were documented by CD 163 and CD 204 immunostainings. Statistically, no significant differences in age, gender, tumor location, size, and lymphovascular and perineural invasion between the case group with TAMs and pT- as well as stage-matched controls were reported; furthermore, the case group showed lower frequency of lymph node metastasis (<i>p</i> = 0.02). In addition, a significantly different clinical course and overall survival rate were also observed in gastric adenocarcinomas with M1 TAMs (<i>p</i> = 0.02) in comparison to controls. These results suggest that tumor-associated M1 macrophages are related to a quite indolent growth and a better prognosis of patients with this peculiar variant of gastric adenocarcinomas. |
| first_indexed | 2024-03-10T04:04:44Z |
| format | Article |
| id | doaj.art-da8e7f034ba347d0b719eba995e649ef |
| institution | Directory Open Access Journal |
| issn | 2624-5647 |
| language | English |
| last_indexed | 2024-03-10T04:04:44Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gastrointestinal Disorders |
| spelling | doaj.art-da8e7f034ba347d0b719eba995e649ef2023-11-23T08:27:06ZengMDPI AGGastrointestinal Disorders2624-56472021-10-013420721710.3390/gidisord3040020M1 Polarized Tumor-Associated Macrophages (TAMs) as Promising Prognostic Signature in Stage I–II Gastric AdenocarcinomasAntonio Ieni0Rosario Alberto Caruso1Cristina Pizzimenti2Giuseppe Giuffrè3Eleonora Irato4Luciana Rigoli5Giuseppe Navarra6Guido Fadda7Giovanni Tuccari8Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyTranslational Molecular Medicine and Surgery, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyIntegrated Cancer Registry of Oriental Sicily, 95123 Catania, ItalyDepartment of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyTumor-associated macrophages (TAMs) may be noticed in gastric carcinomas (GC), but their clinicopathological significance has not been yet explored. From a histological review of 400 cases of tubular/papillary adenocarcinomas, 24 cases of stage I–II gastric adenocarcinomas with intraglandular and stromal TAMs were identified. Their clinicopathological features were compared with 72 pT-matched as well as stage-matched control cases of adenocarcinomas without TAMs. TAMs present in GC cases were present either in glands or in neoplastic stroma, showing an immunoreactivity for CD68 and CD80; sometimes, they were organized in mature granulomas with occasional giant cells. Therefore, the stained TAMs were reminiscent of a specific polarized macrophage M1 phenotype; however, in any case of our cohort, no M2 phenotype macrophages were documented by CD 163 and CD 204 immunostainings. Statistically, no significant differences in age, gender, tumor location, size, and lymphovascular and perineural invasion between the case group with TAMs and pT- as well as stage-matched controls were reported; furthermore, the case group showed lower frequency of lymph node metastasis (<i>p</i> = 0.02). In addition, a significantly different clinical course and overall survival rate were also observed in gastric adenocarcinomas with M1 TAMs (<i>p</i> = 0.02) in comparison to controls. These results suggest that tumor-associated M1 macrophages are related to a quite indolent growth and a better prognosis of patients with this peculiar variant of gastric adenocarcinomas.https://www.mdpi.com/2624-5647/3/4/20gastric adenocarcinomatumor microenvironmenttumor-associated macrophagesCD 68/CD80 expressionprognosis |
| spellingShingle | Antonio Ieni Rosario Alberto Caruso Cristina Pizzimenti Giuseppe Giuffrè Eleonora Irato Luciana Rigoli Giuseppe Navarra Guido Fadda Giovanni Tuccari M1 Polarized Tumor-Associated Macrophages (TAMs) as Promising Prognostic Signature in Stage I–II Gastric Adenocarcinomas Gastrointestinal Disorders gastric adenocarcinoma tumor microenvironment tumor-associated macrophages CD 68/CD80 expression prognosis |
| title | M1 Polarized Tumor-Associated Macrophages (TAMs) as Promising Prognostic Signature in Stage I–II Gastric Adenocarcinomas |
| title_full | M1 Polarized Tumor-Associated Macrophages (TAMs) as Promising Prognostic Signature in Stage I–II Gastric Adenocarcinomas |
| title_fullStr | M1 Polarized Tumor-Associated Macrophages (TAMs) as Promising Prognostic Signature in Stage I–II Gastric Adenocarcinomas |
| title_full_unstemmed | M1 Polarized Tumor-Associated Macrophages (TAMs) as Promising Prognostic Signature in Stage I–II Gastric Adenocarcinomas |
| title_short | M1 Polarized Tumor-Associated Macrophages (TAMs) as Promising Prognostic Signature in Stage I–II Gastric Adenocarcinomas |
| title_sort | m1 polarized tumor associated macrophages tams as promising prognostic signature in stage i ii gastric adenocarcinomas |
| topic | gastric adenocarcinoma tumor microenvironment tumor-associated macrophages CD 68/CD80 expression prognosis |
| url | https://www.mdpi.com/2624-5647/3/4/20 |
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