Can the Development of AKI be Predicted in COVID-19 Patients with Severe Pneumonia?
Objective: Coronavirus disease-2019 (COVID-19) may cause severe respiratory disease, glomerular dysfunction and acute tubular necrosis. Lactate dehydrogenase (LDH), C-reactive protein (CRP), D-dimer, lymphopenia and increased neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) associa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-09-01
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| Series: | Türk Yoğun Bakim Derneği Dergisi |
| Subjects: | |
| Online Access: | https://www.turkishjic.org/archives/archive-detail/article-preview/can-the-development-of-ak-be-predicted-in-covd-19-/51870 |
| _version_ | 1797919471932801024 |
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| author | Rabia Sarı Küçük Asime Ay Esra Dağlı Rabia Gülsüm Aydın Namigar Turgut |
| author_facet | Rabia Sarı Küçük Asime Ay Esra Dağlı Rabia Gülsüm Aydın Namigar Turgut |
| author_sort | Rabia Sarı Küçük |
| collection | DOAJ |
| description | Objective: Coronavirus disease-2019 (COVID-19) may cause severe respiratory disease, glomerular dysfunction and acute tubular necrosis. Lactate dehydrogenase (LDH), C-reactive protein (CRP), D-dimer, lymphopenia and increased neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) associated with poor prognosis. We investigated the effects of these mediators on the development of acute kidney injury (AKI).
Materials and Methods: Patients with severe pneumonia with the diagnosis COVID-19 were included in the retrospective study. Three subgroups were created: Group 1: patients who developed AKI at admission or at follow-up to the intensive care unit (ICU), group 2: those without AKI, group 3: Patients who developed AKI on the basis of chronic kidney disease. Demographic data, comorbidities, lactate, D-dimer, CRP, LDH, NLR, PLR, mortality were recorded and compared.
Results: Two hundred fifty six patients were evaluated. Group 2 D-dimer levels before ICU were significantly lower than those in group 3. Group 2 last day D-dimer levels were significantly lower than those of group 3 and group 1. Admission LDH values were higher in the group 1 than in groups 2 and 3. Last day LDH values were higher in the group 1 than in group 2. NLR values were higher in group 3 than in group 2 on the 6th day. Last day PLR values were lower in the group 1 than in group 2. No significant difference was present between the groups in terms of D-dimer, LDH, NLR, PLR levels at the other time points.
Conclusion: The contribution of laboratory findings in determining the risk of AKI has not been clarified. |
| first_indexed | 2024-04-10T13:46:04Z |
| format | Article |
| id | doaj.art-da8fbb7b91c943528768eb9a8b0a800a |
| institution | Directory Open Access Journal |
| issn | 2146-6416 2147-267X |
| language | English |
| last_indexed | 2024-04-10T13:46:04Z |
| publishDate | 2022-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Yoğun Bakim Derneği Dergisi |
| spelling | doaj.art-da8fbb7b91c943528768eb9a8b0a800a2023-02-15T16:10:59ZengGalenos YayineviTürk Yoğun Bakim Derneği Dergisi2146-64162147-267X2022-09-0120Suppl 1718010.4274/tybd.galenos.2022.0502513049054Can the Development of AKI be Predicted in COVID-19 Patients with Severe Pneumonia?Rabia Sarı Küçük0https://orcid.org/0000-0002-7597-8279Asime Ay1https://orcid.org/0000-0002-5517-7191Esra Dağlı2https://orcid.org/0000-0002-6178-8351Rabia Gülsüm Aydın3https://orcid.org/0000-0002-6022-8205Namigar Turgut4https://orcid.org/0000-0003-0252-3377University of Health Sciences Turkey, Prof. Dr. Cemil Taşcıoğlu City Hospital, Clinic of Intensive Care, İstanbul, TurkeyUniversity of Health Sciences Turkey, Prof. Dr. Cemil Taşcıoğlu City Hospital, Clinic of Intensive Care, İstanbul, TurkeyUniversity of Health Sciences Turkey, Prof. Dr. Cemil Taşcıoğlu City Hospital, Clinic of Intensive Care, İstanbul, TurkeyUniversity of Health Sciences Turkey, Prof. Dr. Cemil Taşcıoğlu City Hospital, Clinic of Intensive Care, İstanbul, TurkeyUniversity of Health Sciences Turkey, Prof. Dr. Cemil Taşcıoğlu City Hospital, Clinic of Intensive Care, İstanbul, TurkeyObjective: Coronavirus disease-2019 (COVID-19) may cause severe respiratory disease, glomerular dysfunction and acute tubular necrosis. Lactate dehydrogenase (LDH), C-reactive protein (CRP), D-dimer, lymphopenia and increased neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) associated with poor prognosis. We investigated the effects of these mediators on the development of acute kidney injury (AKI). Materials and Methods: Patients with severe pneumonia with the diagnosis COVID-19 were included in the retrospective study. Three subgroups were created: Group 1: patients who developed AKI at admission or at follow-up to the intensive care unit (ICU), group 2: those without AKI, group 3: Patients who developed AKI on the basis of chronic kidney disease. Demographic data, comorbidities, lactate, D-dimer, CRP, LDH, NLR, PLR, mortality were recorded and compared. Results: Two hundred fifty six patients were evaluated. Group 2 D-dimer levels before ICU were significantly lower than those in group 3. Group 2 last day D-dimer levels were significantly lower than those of group 3 and group 1. Admission LDH values were higher in the group 1 than in groups 2 and 3. Last day LDH values were higher in the group 1 than in group 2. NLR values were higher in group 3 than in group 2 on the 6th day. Last day PLR values were lower in the group 1 than in group 2. No significant difference was present between the groups in terms of D-dimer, LDH, NLR, PLR levels at the other time points. Conclusion: The contribution of laboratory findings in determining the risk of AKI has not been clarified.https://www.turkishjic.org/archives/archive-detail/article-preview/can-the-development-of-ak-be-predicted-in-covd-19-/51870covid-19severe pneumoniaacute kidney injury |
| spellingShingle | Rabia Sarı Küçük Asime Ay Esra Dağlı Rabia Gülsüm Aydın Namigar Turgut Can the Development of AKI be Predicted in COVID-19 Patients with Severe Pneumonia? Türk Yoğun Bakim Derneği Dergisi covid-19 severe pneumonia acute kidney injury |
| title | Can the Development of AKI be Predicted in COVID-19 Patients with Severe Pneumonia? |
| title_full | Can the Development of AKI be Predicted in COVID-19 Patients with Severe Pneumonia? |
| title_fullStr | Can the Development of AKI be Predicted in COVID-19 Patients with Severe Pneumonia? |
| title_full_unstemmed | Can the Development of AKI be Predicted in COVID-19 Patients with Severe Pneumonia? |
| title_short | Can the Development of AKI be Predicted in COVID-19 Patients with Severe Pneumonia? |
| title_sort | can the development of aki be predicted in covid 19 patients with severe pneumonia |
| topic | covid-19 severe pneumonia acute kidney injury |
| url | https://www.turkishjic.org/archives/archive-detail/article-preview/can-the-development-of-ak-be-predicted-in-covd-19-/51870 |
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