Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and accounts for most cases of dementia. The prevalence of AD has increased in the current rapidly aging society and contributes to a heavy burden on families and society. Despite the profound impact of AD, current treatments are un...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/15/8208 |
| _version_ | 1797525545849716736 |
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| author | Tien-Wei Yu Hsien-Yuan Lane Chieh-Hsin Lin |
| author_facet | Tien-Wei Yu Hsien-Yuan Lane Chieh-Hsin Lin |
| author_sort | Tien-Wei Yu |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a progressive neurodegenerative disease and accounts for most cases of dementia. The prevalence of AD has increased in the current rapidly aging society and contributes to a heavy burden on families and society. Despite the profound impact of AD, current treatments are unable to achieve satisfactory therapeutic effects or stop the progression of the disease. Finding novel treatments for AD has become urgent. In this paper, we reviewed novel therapeutic approaches in five categories: anti-amyloid therapy, anti-tau therapy, anti-neuroinflammatory therapy, neuroprotective agents including N-methyl-D-aspartate (NMDA) receptor modulators, and brain stimulation. The trend of therapeutic development is shifting from a single pathological target to a more complex mechanism, such as the neuroinflammatory and neurodegenerative processes. While drug repositioning may accelerate pharmacological development, non-pharmacological interventions, especially repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), also have the potential for clinical application. In the future, it is possible for physicians to choose appropriate interventions individually on the basis of precision medicine. |
| first_indexed | 2024-03-10T09:14:27Z |
| format | Article |
| id | doaj.art-da902ecf8d784f48a437e114ba0d34d6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:14:27Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-da902ecf8d784f48a437e114ba0d34d62023-11-22T05:44:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012215820810.3390/ijms22158208Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated ReviewTien-Wei Yu0Hsien-Yuan Lane1Chieh-Hsin Lin2Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Psychiatry and Brain Disease Research Center, China Medical University Hospital, Taichung 40402, TaiwanDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanAlzheimer’s disease (AD) is a progressive neurodegenerative disease and accounts for most cases of dementia. The prevalence of AD has increased in the current rapidly aging society and contributes to a heavy burden on families and society. Despite the profound impact of AD, current treatments are unable to achieve satisfactory therapeutic effects or stop the progression of the disease. Finding novel treatments for AD has become urgent. In this paper, we reviewed novel therapeutic approaches in five categories: anti-amyloid therapy, anti-tau therapy, anti-neuroinflammatory therapy, neuroprotective agents including N-methyl-D-aspartate (NMDA) receptor modulators, and brain stimulation. The trend of therapeutic development is shifting from a single pathological target to a more complex mechanism, such as the neuroinflammatory and neurodegenerative processes. While drug repositioning may accelerate pharmacological development, non-pharmacological interventions, especially repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), also have the potential for clinical application. In the future, it is possible for physicians to choose appropriate interventions individually on the basis of precision medicine.https://www.mdpi.com/1422-0067/22/15/8208Alzheimer’s diseaseamyloidtauNMDAneuroinflammationneuroprotection |
| spellingShingle | Tien-Wei Yu Hsien-Yuan Lane Chieh-Hsin Lin Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review International Journal of Molecular Sciences Alzheimer’s disease amyloid tau NMDA neuroinflammation neuroprotection |
| title | Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review |
| title_full | Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review |
| title_fullStr | Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review |
| title_full_unstemmed | Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review |
| title_short | Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review |
| title_sort | novel therapeutic approaches for alzheimer s disease an updated review |
| topic | Alzheimer’s disease amyloid tau NMDA neuroinflammation neuroprotection |
| url | https://www.mdpi.com/1422-0067/22/15/8208 |
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