Sex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imaging
Highlights 1. Female patients with HCM showed worse LV remodeling with a higher indexed LV mass and a smaller indexed LV end-diastolic volume (measured by CMR) at the time of ASA. 2. Both men and women exhibited the LV reverse remodeling, however, men experienced more favorable LV reverse remodeling...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-022-00447-x |
| _version_ | 1818488568952127488 |
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| author | You-Zhou Chen Xing-Shan Zhao Jian-Song Yuan Yan Zhang Wei Liu Shu-Bin Qiao |
| author_facet | You-Zhou Chen Xing-Shan Zhao Jian-Song Yuan Yan Zhang Wei Liu Shu-Bin Qiao |
| author_sort | You-Zhou Chen |
| collection | DOAJ |
| description | Highlights 1. Female patients with HCM showed worse LV remodeling with a higher indexed LV mass and a smaller indexed LV end-diastolic volume (measured by CMR) at the time of ASA. 2. Both men and women exhibited the LV reverse remodeling, however, men experienced more favorable LV reverse remodeling than women after ASA. The overall percentage of the LVM index regression was greater among men than women. 3. Women with HCM had worse relative composite endpoint than men. Sex and LV mass preablation were independent predictors of cardiovascular outcomes. 4. Sex appears to be a significant modifier in HCM patients receiving ASA treatment and highlighted the need for a different approach to women with HCM, such as improving women’s awareness of diagnosis and follow-up management as well as earlier referral for advanced therapies (e.g., septal reduction therapy and ICD implantation). |
| first_indexed | 2024-12-10T16:52:54Z |
| format | Article |
| id | doaj.art-da90f30c90b9403e975d5263a6280dc5 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-12-10T16:52:54Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-da90f30c90b9403e975d5263a6280dc52022-12-22T01:40:50ZengBMCBiology of Sex Differences2042-64102022-07-0113111110.1186/s13293-022-00447-xSex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imagingYou-Zhou Chen0Xing-Shan Zhao1Jian-Song Yuan2Yan Zhang3Wei Liu4Shu-Bin Qiao5Department of Cardiology, Beijing Jishuitan HosptialDepartment of Cardiology, Beijing Jishuitan HosptialDepartment of Cardiology, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Magnetic Resonance Imaging, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Beijing Jishuitan HosptialDepartment of Cardiology, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeHighlights 1. Female patients with HCM showed worse LV remodeling with a higher indexed LV mass and a smaller indexed LV end-diastolic volume (measured by CMR) at the time of ASA. 2. Both men and women exhibited the LV reverse remodeling, however, men experienced more favorable LV reverse remodeling than women after ASA. The overall percentage of the LVM index regression was greater among men than women. 3. Women with HCM had worse relative composite endpoint than men. Sex and LV mass preablation were independent predictors of cardiovascular outcomes. 4. Sex appears to be a significant modifier in HCM patients receiving ASA treatment and highlighted the need for a different approach to women with HCM, such as improving women’s awareness of diagnosis and follow-up management as well as earlier referral for advanced therapies (e.g., septal reduction therapy and ICD implantation).https://doi.org/10.1186/s13293-022-00447-xHypertrophic cardiomyopathyAlcohol septal ablationRemodelingSex |
| spellingShingle | You-Zhou Chen Xing-Shan Zhao Jian-Song Yuan Yan Zhang Wei Liu Shu-Bin Qiao Sex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imaging Biology of Sex Differences Hypertrophic cardiomyopathy Alcohol septal ablation Remodeling Sex |
| title | Sex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imaging |
| title_full | Sex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imaging |
| title_fullStr | Sex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imaging |
| title_full_unstemmed | Sex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imaging |
| title_short | Sex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imaging |
| title_sort | sex related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy insights from cardiovascular magnetic resonance imaging |
| topic | Hypertrophic cardiomyopathy Alcohol septal ablation Remodeling Sex |
| url | https://doi.org/10.1186/s13293-022-00447-x |
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