Sulfur-containing amino acids and their metabolites in atrial fibrosis
Atrial fibrosis, a symbol of atrial structural remodelling, is a complex process involved in the occurrence and maintenance of atrial fibrillation (AF). Atrial fibrosis is regulated by multiple factors. Sulfur containing amino acids and their metabolites, such as hydrogen sulfide (H2S) and taurine,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1063241/full |
| _version_ | 1818470904382881792 |
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| author | Rui Wang Rui Wang Rui Wang Yong Fen Qi Yong Fen Qi Yong Fen Qi Chun Hua Ding Chun Hua Ding Da Zhang Da Zhang |
| author_facet | Rui Wang Rui Wang Rui Wang Yong Fen Qi Yong Fen Qi Yong Fen Qi Chun Hua Ding Chun Hua Ding Da Zhang Da Zhang |
| author_sort | Rui Wang |
| collection | DOAJ |
| description | Atrial fibrosis, a symbol of atrial structural remodelling, is a complex process involved in the occurrence and maintenance of atrial fibrillation (AF). Atrial fibrosis is regulated by multiple factors. Sulfur containing amino acids and their metabolites, such as hydrogen sulfide (H2S) and taurine, can inhibit the process of atrial fibrosis and alleviate atrial remodeling. However, homocysteine can promote the activation of atrial fibroblasts and further promote atrial fibrosis. In this review, we will focus on the recent progress in atrial structural changes and molecular mechanisms of atrial fibrosis, as well as the regulatory roles and possible mechanisms of sulfur containing amino acids and their metabolites in atrial fibrosis. It is expected to provide new ideas for clarifying the mechanism of atrial fibrosis and finding targets to inhibit the progress of atrial fibrosis. |
| first_indexed | 2024-04-13T21:43:47Z |
| format | Article |
| id | doaj.art-da91baff6f9049d4b6073269c50b1d20 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T21:43:47Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-da91baff6f9049d4b6073269c50b1d202022-12-22T02:28:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.10632411063241Sulfur-containing amino acids and their metabolites in atrial fibrosisRui Wang0Rui Wang1Rui Wang2Yong Fen Qi3Yong Fen Qi4Yong Fen Qi5Chun Hua Ding6Chun Hua Ding7Da Zhang8Da Zhang9Laboratory of Cardiovascular Bioactive Molecule, School of Basic Medical Sciences, Peking University, Beijing, ChinaKey Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center, Beijing, ChinaDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, ChinaLaboratory of Cardiovascular Bioactive Molecule, School of Basic Medical Sciences, Peking University, Beijing, ChinaKey Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center, Beijing, ChinaDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, ChinaCardiac Department, Aerospace Center Hospital, Beijing, ChinaPeking University Aerospace School of Clinical Medicine, Beijing, ChinaCardiac Department, Aerospace Center Hospital, Beijing, ChinaPeking University Aerospace School of Clinical Medicine, Beijing, ChinaAtrial fibrosis, a symbol of atrial structural remodelling, is a complex process involved in the occurrence and maintenance of atrial fibrillation (AF). Atrial fibrosis is regulated by multiple factors. Sulfur containing amino acids and their metabolites, such as hydrogen sulfide (H2S) and taurine, can inhibit the process of atrial fibrosis and alleviate atrial remodeling. However, homocysteine can promote the activation of atrial fibroblasts and further promote atrial fibrosis. In this review, we will focus on the recent progress in atrial structural changes and molecular mechanisms of atrial fibrosis, as well as the regulatory roles and possible mechanisms of sulfur containing amino acids and their metabolites in atrial fibrosis. It is expected to provide new ideas for clarifying the mechanism of atrial fibrosis and finding targets to inhibit the progress of atrial fibrosis.https://www.frontiersin.org/articles/10.3389/fphar.2022.1063241/fullsulfur-containing amino acidatrial fibrosishydrogen sulfidetaurinehomocysteine |
| spellingShingle | Rui Wang Rui Wang Rui Wang Yong Fen Qi Yong Fen Qi Yong Fen Qi Chun Hua Ding Chun Hua Ding Da Zhang Da Zhang Sulfur-containing amino acids and their metabolites in atrial fibrosis Frontiers in Pharmacology sulfur-containing amino acid atrial fibrosis hydrogen sulfide taurine homocysteine |
| title | Sulfur-containing amino acids and their metabolites in atrial fibrosis |
| title_full | Sulfur-containing amino acids and their metabolites in atrial fibrosis |
| title_fullStr | Sulfur-containing amino acids and their metabolites in atrial fibrosis |
| title_full_unstemmed | Sulfur-containing amino acids and their metabolites in atrial fibrosis |
| title_short | Sulfur-containing amino acids and their metabolites in atrial fibrosis |
| title_sort | sulfur containing amino acids and their metabolites in atrial fibrosis |
| topic | sulfur-containing amino acid atrial fibrosis hydrogen sulfide taurine homocysteine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1063241/full |
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