Liver MRI and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinoma
Abstract To identify the gadoxetic acid (GA)-enhanced magnetic resonance imaging (MRI) and laboratory findings that enable prediction of treatment response and disease-free survival (DFS) after the first session of drug eluting bead transarterial chemoembolization (DEB-TACE) in patients with hepatoc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01839-6 |
| _version_ | 1819009500575694848 |
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| author | Jeong Yeop Lee Byung Chan Lee Hyoung Ook Kim Suk Hee Heo Sang Soo Shin Yong Yeon Jeong |
| author_facet | Jeong Yeop Lee Byung Chan Lee Hyoung Ook Kim Suk Hee Heo Sang Soo Shin Yong Yeon Jeong |
| author_sort | Jeong Yeop Lee |
| collection | DOAJ |
| description | Abstract To identify the gadoxetic acid (GA)-enhanced magnetic resonance imaging (MRI) and laboratory findings that enable prediction of treatment response and disease-free survival (DFS) after the first session of drug eluting bead transarterial chemoembolization (DEB-TACE) in patients with hepatocellular carcinoma (HCC). A total of 55 patients who underwent GA-enhanced MRI and DEB-TACE from January 2014 to December 2018 were included. All MRI features were reviewed by two radiologists. Treatment response was evaluated according to the modified Response Evaluation Criteria in Solid Tumors. Univariate and multivariate logistic regression analyses were used to determine predictive factors of treatment response and DFS, respectively. A total of 27 patients (49.1%) achieved complete response (CR) after one session of treatment. There were no significant differences between the two groups in terms of clinical and laboratory characteristics. Heterogeneous signal intensity in the hepatobiliary phase (HBP) was the only independent predictor of non-CR (odds ratio, 4.807; p = 0.048). Recurrent HCC was detected in 19 patients (70.4%) after CR. In the multivariate analysis, elevated serum alpha-fetoprotein (AFP) level (≥ 30 ng/mL) was the only significant parameter associated with DFS (hazard ratio, 2.916; p = 0.040). This preliminary study demonstrated that heterogeneous signal intensity in the HBP and high serum AFP were useful predictive factors for poor treatment response and short DFS after DEB-TACE, respectively. |
| first_indexed | 2024-12-21T00:57:21Z |
| format | Article |
| id | doaj.art-da9316a8aead4cac99c625b9cfe7e789 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T00:57:21Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-da9316a8aead4cac99c625b9cfe7e7892022-12-21T19:21:16ZengNature PortfolioScientific Reports2045-23222021-12-0111111010.1038/s41598-021-01839-6Liver MRI and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinomaJeong Yeop Lee0Byung Chan Lee1Hyoung Ook Kim2Suk Hee Heo3Sang Soo Shin4Yong Yeon Jeong5Department of Radiology, Chonnam National University Hwasun HospitalDepartment of Radiology, Chonnam National University Hwasun HospitalDepartment of Radiology, Chonnam National University HospitalDepartment of Radiology, Chonnam National University Hwasun HospitalDepartment of Radiology, Chonnam National University HospitalDepartment of Radiology, Chonnam National University Hwasun HospitalAbstract To identify the gadoxetic acid (GA)-enhanced magnetic resonance imaging (MRI) and laboratory findings that enable prediction of treatment response and disease-free survival (DFS) after the first session of drug eluting bead transarterial chemoembolization (DEB-TACE) in patients with hepatocellular carcinoma (HCC). A total of 55 patients who underwent GA-enhanced MRI and DEB-TACE from January 2014 to December 2018 were included. All MRI features were reviewed by two radiologists. Treatment response was evaluated according to the modified Response Evaluation Criteria in Solid Tumors. Univariate and multivariate logistic regression analyses were used to determine predictive factors of treatment response and DFS, respectively. A total of 27 patients (49.1%) achieved complete response (CR) after one session of treatment. There were no significant differences between the two groups in terms of clinical and laboratory characteristics. Heterogeneous signal intensity in the hepatobiliary phase (HBP) was the only independent predictor of non-CR (odds ratio, 4.807; p = 0.048). Recurrent HCC was detected in 19 patients (70.4%) after CR. In the multivariate analysis, elevated serum alpha-fetoprotein (AFP) level (≥ 30 ng/mL) was the only significant parameter associated with DFS (hazard ratio, 2.916; p = 0.040). This preliminary study demonstrated that heterogeneous signal intensity in the HBP and high serum AFP were useful predictive factors for poor treatment response and short DFS after DEB-TACE, respectively.https://doi.org/10.1038/s41598-021-01839-6 |
| spellingShingle | Jeong Yeop Lee Byung Chan Lee Hyoung Ook Kim Suk Hee Heo Sang Soo Shin Yong Yeon Jeong Liver MRI and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinoma Scientific Reports |
| title | Liver MRI and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinoma |
| title_full | Liver MRI and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinoma |
| title_fullStr | Liver MRI and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinoma |
| title_full_unstemmed | Liver MRI and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinoma |
| title_short | Liver MRI and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinoma |
| title_sort | liver mri and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinoma |
| url | https://doi.org/10.1038/s41598-021-01839-6 |
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