The global establishment of a highly-fluoroquinolone resistant Salmonella enterica serotype Kentucky ST198 strain
While the spread of Salmonella enterica serotype Kentucky resistant to ciprofloxacin across Africa and the Middle-East has been described recently, the presence of this strain in humans, food, various animal species (livestock, pets, and wildlife) and in environment is suspected in other countries o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00395/full |
| _version_ | 1818596725682601984 |
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| author | Simon eLe Hello Amany Abdelrehim Bekhit Amany Abdelrehim Bekhit Sophie eGranier Himel eBarua Janine eBeutlich Magdalena Maria Zając Sebastian eMünch Vitali eSintchenko Brahim eBouchrif Kayode eFashae Jean-Louis ePinsard Lucile eSontag Laetitia eFabre Martine eGarnier Veronique eGuibert Peter eHoward Rene eHendriksen Jens Peter Christensen Paritosh Kumar Biswas Axel eCloeckaert Axel eCloeckaert Wolfgang eRabsch Dariusz eWasyl Benoit eDoublet Benoit eDoublet François-Xavier eWeill |
| author_facet | Simon eLe Hello Amany Abdelrehim Bekhit Amany Abdelrehim Bekhit Sophie eGranier Himel eBarua Janine eBeutlich Magdalena Maria Zając Sebastian eMünch Vitali eSintchenko Brahim eBouchrif Kayode eFashae Jean-Louis ePinsard Lucile eSontag Laetitia eFabre Martine eGarnier Veronique eGuibert Peter eHoward Rene eHendriksen Jens Peter Christensen Paritosh Kumar Biswas Axel eCloeckaert Axel eCloeckaert Wolfgang eRabsch Dariusz eWasyl Benoit eDoublet Benoit eDoublet François-Xavier eWeill |
| author_sort | Simon eLe Hello |
| collection | DOAJ |
| description | While the spread of Salmonella enterica serotype Kentucky resistant to ciprofloxacin across Africa and the Middle-East has been described recently, the presence of this strain in humans, food, various animal species (livestock, pets, and wildlife) and in environment is suspected in other countries of different continents. Here, we report results of an in-depth molecular epidemiological study on a global human and non-human collection of S. Kentucky (n=70).<br/>We performed XbaI-pulsed field gel electrophoresis and multilocus sequence typing, assessed mutations in the quinolone resistance-determining regions, detected β-lactam resistance mechanisms, and screened the presence of the Salmonella genomic island 1 (SGI1). <br/>In this study, we highlight the rapid and extensive worldwide dissemination of the ciprofloxacin-resistant S. Kentucky ST198-X1-SGI1 strain since the mid-2000s in an increasingly large number of contaminated sources, including the environment. This strain has accumulated an increasing number of chromosomal and plasmid resistance determinants and has been identified in the Indian subcontinent, Southeast Asia and Europe since 2010. The second substitution at position 87 in GyrA (replacing the amino acid Asp) appeared helpful for epidemiological studies to track the origin of contamination.<br/>This global study provides evidence leading to the conclusion that high-level resistance to ciprofloxacin in S. Kentucky is a simple microbiological trait that facilitates the identification of the epidemic clone of interest, ST198-X1-SGI1. Taking this into account is essential in order to detect and monitor it easily and to take rapid measures in livestock to ensure control of this infection. <br/> |
| first_indexed | 2024-12-16T11:36:29Z |
| format | Article |
| id | doaj.art-da93cd0343304086aef4eb10c1ee128c |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-16T11:36:29Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-da93cd0343304086aef4eb10c1ee128c2022-12-21T22:33:05ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2013-12-01410.3389/fmicb.2013.0039572203The global establishment of a highly-fluoroquinolone resistant Salmonella enterica serotype Kentucky ST198 strainSimon eLe Hello0Amany Abdelrehim Bekhit1Amany Abdelrehim Bekhit2Sophie eGranier3Himel eBarua4Janine eBeutlich5Magdalena Maria Zając6Sebastian eMünch7Vitali eSintchenko8Brahim eBouchrif9Kayode eFashae10Jean-Louis ePinsard11Lucile eSontag12Laetitia eFabre13Martine eGarnier14Veronique eGuibert15Peter eHoward16Rene eHendriksen17Jens Peter Christensen18Paritosh Kumar Biswas19Axel eCloeckaert20Axel eCloeckaert21Wolfgang eRabsch22Dariusz eWasyl23Benoit eDoublet24Benoit eDoublet25François-Xavier eWeill26Institut PasteurInstitut PasteurMinia UniversityUniversité Paris-EstChittagong Veterinary and Animal Sciences UniversityFederal Institute for Risk AssessmentNational Veterinary Research Institute,Robert Koch Institute,University of Sydney,Institut Pasteur du MarocUniversity of Ibadan,FINALAB,Institut PasteurInstitut PasteurInstitut PasteurInstitut PasteurUniversity of Sydney,Technical University of DenmarkUniversity of CopenhagenChittagong Veterinary and Animal Sciences UniversityINRAUniversité François Rabelais de ToursRobert Koch Institute,National Veterinary Research Institute,INRAUniversité François Rabelais de ToursInstitut PasteurWhile the spread of Salmonella enterica serotype Kentucky resistant to ciprofloxacin across Africa and the Middle-East has been described recently, the presence of this strain in humans, food, various animal species (livestock, pets, and wildlife) and in environment is suspected in other countries of different continents. Here, we report results of an in-depth molecular epidemiological study on a global human and non-human collection of S. Kentucky (n=70).<br/>We performed XbaI-pulsed field gel electrophoresis and multilocus sequence typing, assessed mutations in the quinolone resistance-determining regions, detected β-lactam resistance mechanisms, and screened the presence of the Salmonella genomic island 1 (SGI1). <br/>In this study, we highlight the rapid and extensive worldwide dissemination of the ciprofloxacin-resistant S. Kentucky ST198-X1-SGI1 strain since the mid-2000s in an increasingly large number of contaminated sources, including the environment. This strain has accumulated an increasing number of chromosomal and plasmid resistance determinants and has been identified in the Indian subcontinent, Southeast Asia and Europe since 2010. The second substitution at position 87 in GyrA (replacing the amino acid Asp) appeared helpful for epidemiological studies to track the origin of contamination.<br/>This global study provides evidence leading to the conclusion that high-level resistance to ciprofloxacin in S. Kentucky is a simple microbiological trait that facilitates the identification of the epidemic clone of interest, ST198-X1-SGI1. Taking this into account is essential in order to detect and monitor it easily and to take rapid measures in livestock to ensure control of this infection. <br/>http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00395/fullKentuckyPoultryQRDRST198SGI1MDR Salmonella dissemination |
| spellingShingle | Simon eLe Hello Amany Abdelrehim Bekhit Amany Abdelrehim Bekhit Sophie eGranier Himel eBarua Janine eBeutlich Magdalena Maria Zając Sebastian eMünch Vitali eSintchenko Brahim eBouchrif Kayode eFashae Jean-Louis ePinsard Lucile eSontag Laetitia eFabre Martine eGarnier Veronique eGuibert Peter eHoward Rene eHendriksen Jens Peter Christensen Paritosh Kumar Biswas Axel eCloeckaert Axel eCloeckaert Wolfgang eRabsch Dariusz eWasyl Benoit eDoublet Benoit eDoublet François-Xavier eWeill The global establishment of a highly-fluoroquinolone resistant Salmonella enterica serotype Kentucky ST198 strain Frontiers in Microbiology Kentucky Poultry QRDR ST198 SGI1 MDR Salmonella dissemination |
| title | The global establishment of a highly-fluoroquinolone resistant Salmonella enterica serotype Kentucky ST198 strain |
| title_full | The global establishment of a highly-fluoroquinolone resistant Salmonella enterica serotype Kentucky ST198 strain |
| title_fullStr | The global establishment of a highly-fluoroquinolone resistant Salmonella enterica serotype Kentucky ST198 strain |
| title_full_unstemmed | The global establishment of a highly-fluoroquinolone resistant Salmonella enterica serotype Kentucky ST198 strain |
| title_short | The global establishment of a highly-fluoroquinolone resistant Salmonella enterica serotype Kentucky ST198 strain |
| title_sort | global establishment of a highly fluoroquinolone resistant salmonella enterica serotype kentucky st198 strain |
| topic | Kentucky Poultry QRDR ST198 SGI1 MDR Salmonella dissemination |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00395/full |
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