Loss of testosterone impairs anti-tumor neutrophil function
It is known that there are sex differences in the incidence and prognosis of certain cancers, including melanoma. In this study, the authors utilize a melanoma model to reveal that castrated mice have a higher metastatic burden associated with androgen dependent impaired neutrophil function.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15397-4 |
| _version_ | 1818343253581234176 |
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| author | Janet L. Markman Rebecca A. Porritt Daiko Wakita Malcolm E. Lane Daisy Martinon Magali Noval Rivas Michael Luu Edwin M. Posadas Timothy R. Crother Moshe Arditi |
| author_facet | Janet L. Markman Rebecca A. Porritt Daiko Wakita Malcolm E. Lane Daisy Martinon Magali Noval Rivas Michael Luu Edwin M. Posadas Timothy R. Crother Moshe Arditi |
| author_sort | Janet L. Markman |
| collection | DOAJ |
| description | It is known that there are sex differences in the incidence and prognosis of certain cancers, including melanoma. In this study, the authors utilize a melanoma model to reveal that castrated mice have a higher metastatic burden associated with androgen dependent impaired neutrophil function. |
| first_indexed | 2024-12-13T16:27:39Z |
| format | Article |
| id | doaj.art-da94dd5ff86540ef8cf0216912c0ab16 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:27:39Z |
| publishDate | 2020-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-da94dd5ff86540ef8cf0216912c0ab162022-12-21T23:38:34ZengNature PortfolioNature Communications2041-17232020-03-0111111510.1038/s41467-020-15397-4Loss of testosterone impairs anti-tumor neutrophil functionJanet L. Markman0Rebecca A. Porritt1Daiko Wakita2Malcolm E. Lane3Daisy Martinon4Magali Noval Rivas5Michael Luu6Edwin M. Posadas7Timothy R. Crother8Moshe Arditi9Department of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical CenterDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical CenterDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical CenterDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical CenterDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical CenterDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical CenterBiostatistics and Bioinformatics Core, Cedars-Sinai Medical CenterUrologic Oncology Program/Uro-Oncology Research Laboratories, Samuel Oschin Comprehensive Center Institute, Cedars-Sinai Medical CenterDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical CenterDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical CenterIt is known that there are sex differences in the incidence and prognosis of certain cancers, including melanoma. In this study, the authors utilize a melanoma model to reveal that castrated mice have a higher metastatic burden associated with androgen dependent impaired neutrophil function.https://doi.org/10.1038/s41467-020-15397-4 |
| spellingShingle | Janet L. Markman Rebecca A. Porritt Daiko Wakita Malcolm E. Lane Daisy Martinon Magali Noval Rivas Michael Luu Edwin M. Posadas Timothy R. Crother Moshe Arditi Loss of testosterone impairs anti-tumor neutrophil function Nature Communications |
| title | Loss of testosterone impairs anti-tumor neutrophil function |
| title_full | Loss of testosterone impairs anti-tumor neutrophil function |
| title_fullStr | Loss of testosterone impairs anti-tumor neutrophil function |
| title_full_unstemmed | Loss of testosterone impairs anti-tumor neutrophil function |
| title_short | Loss of testosterone impairs anti-tumor neutrophil function |
| title_sort | loss of testosterone impairs anti tumor neutrophil function |
| url | https://doi.org/10.1038/s41467-020-15397-4 |
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