Loss of testosterone impairs anti-tumor neutrophil function
It is known that there are sex differences in the incidence and prognosis of certain cancers, including melanoma. In this study, the authors utilize a melanoma model to reveal that castrated mice have a higher metastatic burden associated with androgen dependent impaired neutrophil function.
Main Authors: | Janet L. Markman, Rebecca A. Porritt, Daiko Wakita, Malcolm E. Lane, Daisy Martinon, Magali Noval Rivas, Michael Luu, Edwin M. Posadas, Timothy R. Crother, Moshe Arditi |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2020-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-15397-4 |
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