Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization
Abstract Purpose To compare integrated slice-specific dynamic shimming (iShim) diffusion weighted imaging (DWI) and single-shot echo-planar imaging (SS-EPI) DWI in image quality and pathological characterization of rectal cancer. Materials and methods A total of 193 consecutive rectal tumor patients...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Cancer Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40644-021-00403-9 |
| _version_ | 1818440393903046656 |
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| author | Jianxing Qiu Jing Liu Zhongxu Bi Xiaowei Sun Xin Wang Junling Zhang Chengwen Liu Jinxia Zhu Naishan Qin |
| author_facet | Jianxing Qiu Jing Liu Zhongxu Bi Xiaowei Sun Xin Wang Junling Zhang Chengwen Liu Jinxia Zhu Naishan Qin |
| author_sort | Jianxing Qiu |
| collection | DOAJ |
| description | Abstract Purpose To compare integrated slice-specific dynamic shimming (iShim) diffusion weighted imaging (DWI) and single-shot echo-planar imaging (SS-EPI) DWI in image quality and pathological characterization of rectal cancer. Materials and methods A total of 193 consecutive rectal tumor patients were enrolled for retrospective analysis. Among them, 101 patients underwent iShim-DWI (b = 0, 800, and 1600 s/mm2) and 92 patients underwent SS-EPI-DWI (b = 0, and 1000 s/mm2). Qualitative analyses of both DWI techniques was performed by two independent readers; including adequate fat suppression, the presence of artifacts and image quality. Quantitative analysis was performed by calculating standard deviation (SD) of the gluteus maximus, signal intensity (SI) of lesion and residual normal rectal wall, apparent diffusion coefficient (ADC) values (generated by b values of 0, 800 and 1600 s/mm2 for iShim-DWI, and by b values of 0 and 1000 s/mm2 for SS-EPI-DWI) and image quality parameters, such as signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of primary rectal tumor. For the primary rectal cancer, two pathological groups were divided according to pathological results: Group 1 (well-differentiated) and Group 2 (poorly differentiated). Statistical analyses were performed with p < 0.05 as significant difference. Results Compared with SS-EPI-DWI, significantly higher scores of image quality were obtained in iShim-DWI cases (P < 0.001). The SDbackground was significantly reduced on b = 1600 s/mm2 images and ADC maps of iShim-DWI. Both SNR and CNR of b = 800 s/mm2 and b = 1600 s/mm2 images in iShim-DWI were higher than those of b = 1000 s/mm2 images in SS-EPI-DWI. In primary rectal cancer of iShim-DWI cohort, SIlesion was significantly higher than SIrectum in both b = 800 and 1600 s/mm2 images. ADC values were significantly lower in Group 2 (0.732 ± 0.08) × 10− 3 mm2/s) than those in Group 1 ((0.912 ± 0.21) × 10− 3 mm2/s). ROC analyses showed significance of ADC values and SIlesion between the two groups. Conclusion iShim-DWI with b values of 0, 800 and 1600 s/mm2 is a promising technique of high image quality in rectal tumor imaging, and has potential ability to differentiate rectal cancer from normal wall and predicting pathological characterization. |
| first_indexed | 2024-12-14T18:11:39Z |
| format | Article |
| id | doaj.art-da94ffbafb4e4ebe88f413688eaecffe |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-12-14T18:11:39Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-da94ffbafb4e4ebe88f413688eaecffe2022-12-21T22:52:17ZengBMCCancer Imaging1470-73302021-04-0121111310.1186/s40644-021-00403-9Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterizationJianxing Qiu0Jing Liu1Zhongxu Bi2Xiaowei Sun3Xin Wang4Junling Zhang5Chengwen Liu6Jinxia Zhu7Naishan Qin8Department of Radiology, Peking University First HospitalDepartment of Radiology, Peking University First HospitalDepartment of Radiology, Peking University First HospitalDepartment of Radiology, Peking University First HospitalDepartment of Gastrointestinal Surgery, Peking University First HospitalDepartment of Gastrointestinal Surgery, Peking University First HospitalMR Collaboration, Siemens Healthcare, Ltd.MR Collaboration, Siemens Healthcare, Ltd.Department of Radiology, Peking University First HospitalAbstract Purpose To compare integrated slice-specific dynamic shimming (iShim) diffusion weighted imaging (DWI) and single-shot echo-planar imaging (SS-EPI) DWI in image quality and pathological characterization of rectal cancer. Materials and methods A total of 193 consecutive rectal tumor patients were enrolled for retrospective analysis. Among them, 101 patients underwent iShim-DWI (b = 0, 800, and 1600 s/mm2) and 92 patients underwent SS-EPI-DWI (b = 0, and 1000 s/mm2). Qualitative analyses of both DWI techniques was performed by two independent readers; including adequate fat suppression, the presence of artifacts and image quality. Quantitative analysis was performed by calculating standard deviation (SD) of the gluteus maximus, signal intensity (SI) of lesion and residual normal rectal wall, apparent diffusion coefficient (ADC) values (generated by b values of 0, 800 and 1600 s/mm2 for iShim-DWI, and by b values of 0 and 1000 s/mm2 for SS-EPI-DWI) and image quality parameters, such as signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of primary rectal tumor. For the primary rectal cancer, two pathological groups were divided according to pathological results: Group 1 (well-differentiated) and Group 2 (poorly differentiated). Statistical analyses were performed with p < 0.05 as significant difference. Results Compared with SS-EPI-DWI, significantly higher scores of image quality were obtained in iShim-DWI cases (P < 0.001). The SDbackground was significantly reduced on b = 1600 s/mm2 images and ADC maps of iShim-DWI. Both SNR and CNR of b = 800 s/mm2 and b = 1600 s/mm2 images in iShim-DWI were higher than those of b = 1000 s/mm2 images in SS-EPI-DWI. In primary rectal cancer of iShim-DWI cohort, SIlesion was significantly higher than SIrectum in both b = 800 and 1600 s/mm2 images. ADC values were significantly lower in Group 2 (0.732 ± 0.08) × 10− 3 mm2/s) than those in Group 1 ((0.912 ± 0.21) × 10− 3 mm2/s). ROC analyses showed significance of ADC values and SIlesion between the two groups. Conclusion iShim-DWI with b values of 0, 800 and 1600 s/mm2 is a promising technique of high image quality in rectal tumor imaging, and has potential ability to differentiate rectal cancer from normal wall and predicting pathological characterization.https://doi.org/10.1186/s40644-021-00403-9Rectal CancerIntegrated slice-specific dynamic shimming (iShim); diffusion weighted imaging (DWI)Imaging qualityTumor differentiation |
| spellingShingle | Jianxing Qiu Jing Liu Zhongxu Bi Xiaowei Sun Xin Wang Junling Zhang Chengwen Liu Jinxia Zhu Naishan Qin Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization Cancer Imaging Rectal Cancer Integrated slice-specific dynamic shimming (iShim); diffusion weighted imaging (DWI) Imaging quality Tumor differentiation |
| title | Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization |
| title_full | Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization |
| title_fullStr | Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization |
| title_full_unstemmed | Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization |
| title_short | Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization |
| title_sort | integrated slice specific dynamic shimming diffusion weighted imaging dwi for rectal cancer detection and characterization |
| topic | Rectal Cancer Integrated slice-specific dynamic shimming (iShim); diffusion weighted imaging (DWI) Imaging quality Tumor differentiation |
| url | https://doi.org/10.1186/s40644-021-00403-9 |
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