In-Vitro Experimental Modeling of Oscillatory Respiratory Flow in a CT-Scanned OSAHS Tract
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a highly prevalent respiratory disorder. The knowledge of respiratory flow is an essential prerequisite for the establishment and development of OSAHS physiology, pathology, and clinical medicine. We made the first in-vitro experimental attempt to...
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MDPI AG
2020-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/22/7979 |
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| author | Zhenshan Zhu Yaping Ju Chuhua Zhang |
| author_facet | Zhenshan Zhu Yaping Ju Chuhua Zhang |
| author_sort | Zhenshan Zhu |
| collection | DOAJ |
| description | Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a highly prevalent respiratory disorder. The knowledge of respiratory flow is an essential prerequisite for the establishment and development of OSAHS physiology, pathology, and clinical medicine. We made the first in-vitro experimental attempt to measure the oscillatory flow velocity in a computed tomography (CT) scanned extra-thoracic airway (ETA) model with OSAHS by using the particle image velocimetry (PIV) technique. In order to mimic respiration flow, three techniques were adopted to address difficulties in in-vitro experimental modeling: (1) fabricating the obstructive ETA measurement section with the CT-scanned data of an OSAHS patient airway; (2) maintaining the measurement accuracy by using the optical index-matching technique; (3) reproducing the oscillatory respiratory flow rates with the compiled clinical data of transient tidal volumes. The in-vitro measurements of oscillatory respiratory flow velocity manifested the time evolution of the complex OSAHS flow patterns, and the potential wall collapse of the ETA model with OSAHS. |
| first_indexed | 2024-03-10T14:57:18Z |
| format | Article |
| id | doaj.art-da950939966546949e10cd5242b3f6db |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T14:57:18Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-da950939966546949e10cd5242b3f6db2023-11-20T20:29:47ZengMDPI AGApplied Sciences2076-34172020-11-011022797910.3390/app10227979In-Vitro Experimental Modeling of Oscillatory Respiratory Flow in a CT-Scanned OSAHS TractZhenshan Zhu0Yaping Ju1Chuhua Zhang2Department of Fluid Machinery and Engineering, School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an 710049, ChinaDepartment of Fluid Machinery and Engineering, School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an 710049, ChinaDepartment of Fluid Machinery and Engineering, School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an 710049, ChinaObstructive sleep apnea-hypopnea syndrome (OSAHS) is a highly prevalent respiratory disorder. The knowledge of respiratory flow is an essential prerequisite for the establishment and development of OSAHS physiology, pathology, and clinical medicine. We made the first in-vitro experimental attempt to measure the oscillatory flow velocity in a computed tomography (CT) scanned extra-thoracic airway (ETA) model with OSAHS by using the particle image velocimetry (PIV) technique. In order to mimic respiration flow, three techniques were adopted to address difficulties in in-vitro experimental modeling: (1) fabricating the obstructive ETA measurement section with the CT-scanned data of an OSAHS patient airway; (2) maintaining the measurement accuracy by using the optical index-matching technique; (3) reproducing the oscillatory respiratory flow rates with the compiled clinical data of transient tidal volumes. The in-vitro measurements of oscillatory respiratory flow velocity manifested the time evolution of the complex OSAHS flow patterns, and the potential wall collapse of the ETA model with OSAHS.https://www.mdpi.com/2076-3417/10/22/7979in-vitro experimental modelingCT-scanned OSAHS modeloscillatory respiratory flow ratesparticle image velocimetry techniqueoptical index matching |
| spellingShingle | Zhenshan Zhu Yaping Ju Chuhua Zhang In-Vitro Experimental Modeling of Oscillatory Respiratory Flow in a CT-Scanned OSAHS Tract Applied Sciences in-vitro experimental modeling CT-scanned OSAHS model oscillatory respiratory flow rates particle image velocimetry technique optical index matching |
| title | In-Vitro Experimental Modeling of Oscillatory Respiratory Flow in a CT-Scanned OSAHS Tract |
| title_full | In-Vitro Experimental Modeling of Oscillatory Respiratory Flow in a CT-Scanned OSAHS Tract |
| title_fullStr | In-Vitro Experimental Modeling of Oscillatory Respiratory Flow in a CT-Scanned OSAHS Tract |
| title_full_unstemmed | In-Vitro Experimental Modeling of Oscillatory Respiratory Flow in a CT-Scanned OSAHS Tract |
| title_short | In-Vitro Experimental Modeling of Oscillatory Respiratory Flow in a CT-Scanned OSAHS Tract |
| title_sort | in vitro experimental modeling of oscillatory respiratory flow in a ct scanned osahs tract |
| topic | in-vitro experimental modeling CT-scanned OSAHS model oscillatory respiratory flow rates particle image velocimetry technique optical index matching |
| url | https://www.mdpi.com/2076-3417/10/22/7979 |
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