Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer

Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer

OBJECTIVE: This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis. METHODS: A...

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Bibliographic Details
Main Authors: Rossana de Araújo Catão Zampronha, Ruffo Freitas-Junior, Eddie Fernando Candido Murta, Márcia Antoniazi Michelin, Aline Almeida Barbaresco, Sheila Jorge Adad, Amaurillo Monteiro de Oliveira, Amanda B. Rassi, Glória Jabur Bittar Oton
Format: Article
Language:English
Published: Elsevier España 2013-06-01
Series:Clinics
Subjects:
Human Papillomavirus (HPV)
Cervical Cancer
Prognosis
Survival
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000600809
Description
Summary:OBJECTIVE: This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis. METHODS: A single-center cohort study was conducted with 86 patients who had undergone radical hysterectomy for stage I cervical cancer. Prognostic factors and the presence of HPV 16 and 18 were analyzed using a polymerase chain reaction assay. A univariate analysis using Kaplan-Meier curves was conducted to estimate survival. RESULTS: The prevalence of HPV 16 in the study group was 65.3%, and the prevalence of HPV 18 was 33.3%. The prevalence of infection with both viruses was 26.9%. Overall survival at 5 years was 91% among women with HPV 18 and 96% among those without this virus type (p = 0.133). Among the women with HPV 16, the overall survival was 94%, whereas this rate was 96% among those without this virus type (p = 0.663). Disease-free survival was unaffected by the presence of HPV type 16 or 18. CONCLUSION: In the present study, despite the high prevalence of HPV types 16 and 18, the presence of these virus types did not affect the prognosis of patients with stage I cervical cancer who underwent radical hysterectomy.
ISSN:1807-5932
1980-5322

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