Intraoperative sedation and postoperative analgesic effects of bupivacaine-dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries: A randomized comparative study in Vietnam
We aimed to compare intraoperative sedation and postoperative analgesic effects of brachial plexus block using bupivacaine-dexmedetomidine mixture (BD) versus bupivacaine alone (B) in upper extremity bone surgeries. We conducted a randomized comparative study at Can Tho City, Vietnam. We recruited p...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Mahidol University
2022-05-01
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| Series: | Pharmaceutical Sciences Asia |
| Subjects: | |
| Online Access: | https://pharmacy.mahidol.ac.th/journal/_files/2022-49-3_2.pdf |
| _version_ | 1811302463303581696 |
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| author | Nhung Thi Cam Tran Khanh Hoang Pham Thang Nguyen Dao Huynh Tran Hung Xuan Tong Chung Van Nguyen |
| author_facet | Nhung Thi Cam Tran Khanh Hoang Pham Thang Nguyen Dao Huynh Tran Hung Xuan Tong Chung Van Nguyen |
| author_sort | Nhung Thi Cam Tran |
| collection | DOAJ |
| description | We aimed to compare intraoperative sedation and postoperative analgesic effects of brachial plexus block using bupivacaine-dexmedetomidine mixture (BD) versus bupivacaine alone (B) in upper extremity bone surgeries. We conducted a randomized comparative study at Can Tho City, Vietnam. We recruited patients aged 15 to 75 years, ASA (American Society of Anesthesiology) I-III grade, indicating bone surgeries of arm or forearm with supraclavicular brachial plexus block by ultrasound guidance. One hundred eight included patients were randomly divided into two groups: the BD group (54 patients) received a 30 ml mixture of 0.25% bupivacaine and 100 mcg dexmedetomidine, and the B group (54 patients) received 30 ml of 0.25% bupivacaine. The BD group had a sedative OAA/S score (Observer Assessment of Alertness/Sedation Scale) of level 4, accounting for 87% more than group B 37%, and an OAA/S score of level 3 in the BD group with 5 cases (9.3%) compared with 9 cases (16.7%) in group B, statistically significant difference with p<0.05. The onset and duration of sedative time in group BD was 9.8±3.5 and 92.7±34.1 minutes. The mean of postoperative analgesic time was 970.5±309.5 minutes in group BD statistically significantly longer than group B’s with 552.7±231.2 minutes (p<0.001). In conclusion, a mixture of bupivacaine-dexmedetomidine in brachial plexus block for arm and forearm surgical fractures had greater sedative and postoperative analgesic effects than that of bupivacaine alone. |
| first_indexed | 2024-04-13T07:29:36Z |
| format | Article |
| id | doaj.art-da975cae28044d8da3fbe2bd4001afc3 |
| institution | Directory Open Access Journal |
| issn | 2586-8470 |
| language | English |
| last_indexed | 2024-04-13T07:29:36Z |
| publishDate | 2022-05-01 |
| publisher | Faculty of Pharmacy, Mahidol University |
| record_format | Article |
| series | Pharmaceutical Sciences Asia |
| spelling | doaj.art-da975cae28044d8da3fbe2bd4001afc32022-12-22T02:56:24ZengFaculty of Pharmacy, Mahidol UniversityPharmaceutical Sciences Asia2586-84702022-05-0149322322910.29090/psa.2022.03.21.184Intraoperative sedation and postoperative analgesic effects of bupivacaine-dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries: A randomized comparative study in VietnamNhung Thi Cam Tran0Khanh Hoang Pham1Thang Nguyen2Dao Huynh Tran3Hung Xuan Tong4Chung Van Nguyen5Hoan My Cuu Long Hospital, Can Tho City, VietnamCan Tho University of Medicine Pharmacy, Can Tho City, VietnamCan Tho University of Medicine Pharmacy, Can Tho City, VietnamCan Tho Central General Hospital, Can Tho City, Vietnam 108 Military Central Hospital, Hanoi, VietnamUniversity of Medicine and Pharmacy at Ho Chi Minh City, VietnamWe aimed to compare intraoperative sedation and postoperative analgesic effects of brachial plexus block using bupivacaine-dexmedetomidine mixture (BD) versus bupivacaine alone (B) in upper extremity bone surgeries. We conducted a randomized comparative study at Can Tho City, Vietnam. We recruited patients aged 15 to 75 years, ASA (American Society of Anesthesiology) I-III grade, indicating bone surgeries of arm or forearm with supraclavicular brachial plexus block by ultrasound guidance. One hundred eight included patients were randomly divided into two groups: the BD group (54 patients) received a 30 ml mixture of 0.25% bupivacaine and 100 mcg dexmedetomidine, and the B group (54 patients) received 30 ml of 0.25% bupivacaine. The BD group had a sedative OAA/S score (Observer Assessment of Alertness/Sedation Scale) of level 4, accounting for 87% more than group B 37%, and an OAA/S score of level 3 in the BD group with 5 cases (9.3%) compared with 9 cases (16.7%) in group B, statistically significant difference with p<0.05. The onset and duration of sedative time in group BD was 9.8±3.5 and 92.7±34.1 minutes. The mean of postoperative analgesic time was 970.5±309.5 minutes in group BD statistically significantly longer than group B’s with 552.7±231.2 minutes (p<0.001). In conclusion, a mixture of bupivacaine-dexmedetomidine in brachial plexus block for arm and forearm surgical fractures had greater sedative and postoperative analgesic effects than that of bupivacaine alone.https://pharmacy.mahidol.ac.th/journal/_files/2022-49-3_2.pdfbrachial plexus blockbupivacainedexmedetomidineintraoperative sedationpostoperative pain reliefultrasound guidance |
| spellingShingle | Nhung Thi Cam Tran Khanh Hoang Pham Thang Nguyen Dao Huynh Tran Hung Xuan Tong Chung Van Nguyen Intraoperative sedation and postoperative analgesic effects of bupivacaine-dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries: A randomized comparative study in Vietnam Pharmaceutical Sciences Asia brachial plexus block bupivacaine dexmedetomidine intraoperative sedation postoperative pain relief ultrasound guidance |
| title | Intraoperative sedation and postoperative analgesic effects of bupivacaine-dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries: A randomized comparative study in Vietnam |
| title_full | Intraoperative sedation and postoperative analgesic effects of bupivacaine-dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries: A randomized comparative study in Vietnam |
| title_fullStr | Intraoperative sedation and postoperative analgesic effects of bupivacaine-dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries: A randomized comparative study in Vietnam |
| title_full_unstemmed | Intraoperative sedation and postoperative analgesic effects of bupivacaine-dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries: A randomized comparative study in Vietnam |
| title_short | Intraoperative sedation and postoperative analgesic effects of bupivacaine-dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries: A randomized comparative study in Vietnam |
| title_sort | intraoperative sedation and postoperative analgesic effects of bupivacaine dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries a randomized comparative study in vietnam |
| topic | brachial plexus block bupivacaine dexmedetomidine intraoperative sedation postoperative pain relief ultrasound guidance |
| url | https://pharmacy.mahidol.ac.th/journal/_files/2022-49-3_2.pdf |
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