Bioanalysis of the Ex Vivo Labile PACE4 Inhibitory Peptide Ac-[<span style="font-variant: small-caps">d-</span>Leu]LLLRVK-Amba in Whole Blood Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Quantification

Bioanalysis of the Ex Vivo Labile PACE4 Inhibitory Peptide Ac-[<span style="font-variant: small-caps">d-</span>Leu]LLLRVK-Amba in Whole Blood Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Quantification

The calcium-dependent serine endoprotease PACE4 is evaluated as a therapeutic target for prostate cancer. The peptide Ac-[<span style="font-variant: small-caps;">d</span>-Leu]LLLRVK-amba inhibits PACE4 with high affinity and has shown efficacy in preclinical mice xenograft mode...

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Bibliographic Details
Main Authors: Max Sauter, Jonas Haag, Cindy Bay, Florian Leuschner, Walter E. Haefeli, Tim Christian Kuhn, Jürgen Burhenne
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Pharmaceutics
Subjects:
PACE4
UPLC-MS/MS
micro-sampling
metabolism
bioanalysis
peptide
Online Access:https://www.mdpi.com/1999-4923/15/12/2745

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