The Utility of the Liverpool Adverse Drug Reaction Assessment Tools in the Evaluation of Chemotherapy-Induced Nausea and Vomiting in Children
Introduction: Chemotherapy-induced nausea and vomiting (CINV) are common adverse drug reactions (ADR) experienced by children undergoing treatment for cancer. New paediatric ADR Assessment Causality and Avoidability tools (LCAT and LAAT) of Liverpool are suitable for categorizing factors related to...
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| Format: | Article |
| Language: | English |
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Instituto Nacional de Câncer (INCA)
2023-07-01
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| Series: | Revista Brasileira de Cancerologia |
| Subjects: | |
| Online Access: | https://rbc.inca.gov.br/index.php/revista/article/view/3986 |
| _version_ | 1797225378353250304 |
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| author | Elisangela Costa Lima Thais de Barros Fernandes Marcelo Gerardin Poirot Land Caio Gonzalez Colin Thorbinson Caroline Bains Louise E. Bracken Matthew Peak Barry Pizer |
| author_facet | Elisangela Costa Lima Thais de Barros Fernandes Marcelo Gerardin Poirot Land Caio Gonzalez Colin Thorbinson Caroline Bains Louise E. Bracken Matthew Peak Barry Pizer |
| author_sort | Elisangela Costa Lima |
| collection | DOAJ |
| description |
Introduction: Chemotherapy-induced nausea and vomiting (CINV) are common adverse drug reactions (ADR) experienced by children undergoing treatment for cancer. New paediatric ADR Assessment Causality and Avoidability tools (LCAT and LAAT) of Liverpool are suitable for categorizing factors related to ADR prevention and improving patient care. Still, no studies to date have compared the utility and results of its application for CINV in countries with different levels of development. Objective: To investigate the utility of the Liverpool Adverse Drug Reaction Causality and Avoidability Assessment Tools (LCAT and LAAT) in assessing CINV in children. Method: Prospective observational study of CINV assessment in children aged 4 to 16 years from Alder Hey Children’s Hospital (Liverpool, UK) and “Instituto de Puericultura e Pediatria Martagão Gesteira” (Rio de Janeiro, Brazil). Children (helped by the parents) completed a symptom diary during chemotherapy and for 24 hours after treatment. Information regarding underlying diagnosis, past medical history, and medications administered was collected from the patient record. Case reports were prepared, and the temporal relationship between nausea and vomiting and exposure to chemotherapy, including any strategy to prevent CINV, was recorded. The causality and avoidability were assessed with LCAT and LAAT, respectively. Results: There were 26 reports of CINV in 36 chemotherapy cycles. The causality assessment was ‘definite’ for 24 cases. Twenty ADRs were deemed ‘definitely avoidable’ and four ‘not avoidable’. Selection of inappropriate therapeutic options and non-administration of antiemetic were the most common factors observed in the hospitals studied. Conclusion: The LCAT and LAAT were helpful for assessing CINV in children in two different hospitals.
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| first_indexed | 2024-03-12T22:34:55Z |
| format | Article |
| id | doaj.art-da985bd985b34cd087df04b00618a984 |
| institution | Directory Open Access Journal |
| issn | 2176-9745 |
| language | English |
| last_indexed | 2024-04-24T14:08:04Z |
| publishDate | 2023-07-01 |
| publisher | Instituto Nacional de Câncer (INCA) |
| record_format | Article |
| series | Revista Brasileira de Cancerologia |
| spelling | doaj.art-da985bd985b34cd087df04b00618a9842024-04-03T09:57:31ZengInstituto Nacional de Câncer (INCA)Revista Brasileira de Cancerologia2176-97452023-07-0169310.32635/2176-9745.RBC.2023v69n3.3986The Utility of the Liverpool Adverse Drug Reaction Assessment Tools in the Evaluation of Chemotherapy-Induced Nausea and Vomiting in ChildrenElisangela Costa Lima0Thais de Barros Fernandes1Marcelo Gerardin Poirot Land2Caio Gonzalez3Colin Thorbinson4Caroline Bains5Louise E. Bracken6Matthew Peak7Barry Pizer8Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Farmácia. Rio de Janeiro (RJ), Brazil. Fundação Oswaldo Cruz (Fiocruz), Escola Nacional de Saúde Pública Sérgio Arouca (Ensp).Rio de Janeiro (RJ), Brazil.Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Puericultura e Pediatria Martagão Gesteira. Rio de Janeiro (RJ), Brazil. Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Puericultura e Pediatria Martagão Gesteira. Rio de Janeiro (RJ), Brazil. Alder Hey Children’s NHS Foundation Trust, Paediatric Medicines Research Unit. Liverpool, United Kingdom. Alder Hey Children’s NHS Foundation Trust, Paediatric Medicines Research Unit. Liverpool, United Kingdom. Alder Hey Children’s NHS Foundation Trust, Paediatric Medicines Research Unit. Liverpool, United Kingdom. Alder Hey Children’s NHS Foundation Trust, Paediatric Medicines Research Unit. Liverpool, United Kingdom. Alder Hey Children’s NHS Foundation Trust, Paediatric Medicines Research Unit. Liverpool, United Kingdom. Introduction: Chemotherapy-induced nausea and vomiting (CINV) are common adverse drug reactions (ADR) experienced by children undergoing treatment for cancer. New paediatric ADR Assessment Causality and Avoidability tools (LCAT and LAAT) of Liverpool are suitable for categorizing factors related to ADR prevention and improving patient care. Still, no studies to date have compared the utility and results of its application for CINV in countries with different levels of development. Objective: To investigate the utility of the Liverpool Adverse Drug Reaction Causality and Avoidability Assessment Tools (LCAT and LAAT) in assessing CINV in children. Method: Prospective observational study of CINV assessment in children aged 4 to 16 years from Alder Hey Children’s Hospital (Liverpool, UK) and “Instituto de Puericultura e Pediatria Martagão Gesteira” (Rio de Janeiro, Brazil). Children (helped by the parents) completed a symptom diary during chemotherapy and for 24 hours after treatment. Information regarding underlying diagnosis, past medical history, and medications administered was collected from the patient record. Case reports were prepared, and the temporal relationship between nausea and vomiting and exposure to chemotherapy, including any strategy to prevent CINV, was recorded. The causality and avoidability were assessed with LCAT and LAAT, respectively. Results: There were 26 reports of CINV in 36 chemotherapy cycles. The causality assessment was ‘definite’ for 24 cases. Twenty ADRs were deemed ‘definitely avoidable’ and four ‘not avoidable’. Selection of inappropriate therapeutic options and non-administration of antiemetic were the most common factors observed in the hospitals studied. Conclusion: The LCAT and LAAT were helpful for assessing CINV in children in two different hospitals. https://rbc.inca.gov.br/index.php/revista/article/view/3986drug-related side effects and adverse reactionsnauseavomitingneoplasmschild |
| spellingShingle | Elisangela Costa Lima Thais de Barros Fernandes Marcelo Gerardin Poirot Land Caio Gonzalez Colin Thorbinson Caroline Bains Louise E. Bracken Matthew Peak Barry Pizer The Utility of the Liverpool Adverse Drug Reaction Assessment Tools in the Evaluation of Chemotherapy-Induced Nausea and Vomiting in Children Revista Brasileira de Cancerologia drug-related side effects and adverse reactions nausea vomiting neoplasms child |
| title | The Utility of the Liverpool Adverse Drug Reaction Assessment Tools in the Evaluation of Chemotherapy-Induced Nausea and Vomiting in Children |
| title_full | The Utility of the Liverpool Adverse Drug Reaction Assessment Tools in the Evaluation of Chemotherapy-Induced Nausea and Vomiting in Children |
| title_fullStr | The Utility of the Liverpool Adverse Drug Reaction Assessment Tools in the Evaluation of Chemotherapy-Induced Nausea and Vomiting in Children |
| title_full_unstemmed | The Utility of the Liverpool Adverse Drug Reaction Assessment Tools in the Evaluation of Chemotherapy-Induced Nausea and Vomiting in Children |
| title_short | The Utility of the Liverpool Adverse Drug Reaction Assessment Tools in the Evaluation of Chemotherapy-Induced Nausea and Vomiting in Children |
| title_sort | utility of the liverpool adverse drug reaction assessment tools in the evaluation of chemotherapy induced nausea and vomiting in children |
| topic | drug-related side effects and adverse reactions nausea vomiting neoplasms child |
| url | https://rbc.inca.gov.br/index.php/revista/article/view/3986 |
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