Synthesis and Dual Histamine H1 and H2 Receptor Antagonist Activity of Cyanoguanidine Derivatives

Synthesis and Dual Histamine H1 and H2 Receptor Antagonist Activity of Cyanoguanidine Derivatives

Premedication with a combination of histamine H1 receptor (H1R) and H2 receptor (H2R) antagonists has been suggested as a prophylactic principle, for instance, in anaesthesia and surgery. Aiming at pharmacological hybrids combining H1R and H2R antagonistic activity, a series of cyanoguanidines 14–35...

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Bibliographic Details
Main Authors: Bassem Sadek, Rudi Alisch, Armin Buschauer, Sigurd Elz
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Molecules
Subjects:
dual H1/H2 receptor antagonists
mepyramine
roxatidine
tiotidine
ranitidine
Online Access:http://www.mdpi.com/1420-3049/18/11/14186

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