Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides
Herein, we report the design and characterization of guanosine-containing self-assembling nucleopeptides that form nanosheets and nanofibers. Through spectroscopy and microscopy analysis, we propose that the peptide component of the nucleopeptide drives the assembly into β-sheet structures with hydr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/23/5493 |
| _version_ | 1797547009715994624 |
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| author | Katherine Boback Katherine Bacchi Sarah O’Neill Samantha Brown Jovelt Dorsainvil Jillian E. Smith-Carpenter |
| author_facet | Katherine Boback Katherine Bacchi Sarah O’Neill Samantha Brown Jovelt Dorsainvil Jillian E. Smith-Carpenter |
| author_sort | Katherine Boback |
| collection | DOAJ |
| description | Herein, we report the design and characterization of guanosine-containing self-assembling nucleopeptides that form nanosheets and nanofibers. Through spectroscopy and microscopy analysis, we propose that the peptide component of the nucleopeptide drives the assembly into β-sheet structures with hydrogen-bonded guanosine forming additional secondary structures cooperatively within the peptide framework. Interestingly, the distinct supramolecular morphologies are driven not by metal cation responsiveness common to guanine-based materials, but by the C-terminal peptide chemistry. This work highlights the structural diversity of self-assembling nucleopeptides and will help advance the development of applications for these supramolecular guanosine-containing nucleopeptides. |
| first_indexed | 2024-03-10T14:37:21Z |
| format | Article |
| id | doaj.art-da9a92e6d3e54687bce8cc6c84484e3b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:37:21Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-da9a92e6d3e54687bce8cc6c84484e3b2023-11-20T22:05:38ZengMDPI AGMolecules1420-30492020-11-012523549310.3390/molecules25235493Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing NucleopeptidesKatherine Boback0Katherine Bacchi1Sarah O’Neill2Samantha Brown3Jovelt Dorsainvil4Jillian E. Smith-Carpenter5Department of Chemistry and Biochemistry, Fairfield University, 1073 N. Benson Rd, Fairfield, CT 06824, USADepartment of Chemistry and Biochemistry, Fairfield University, 1073 N. Benson Rd, Fairfield, CT 06824, USADepartment of Chemistry and Biochemistry, Fairfield University, 1073 N. Benson Rd, Fairfield, CT 06824, USADepartment of Chemistry and Biochemistry, Fairfield University, 1073 N. Benson Rd, Fairfield, CT 06824, USADepartment of Chemistry and Biochemistry, Fairfield University, 1073 N. Benson Rd, Fairfield, CT 06824, USADepartment of Chemistry and Biochemistry, Fairfield University, 1073 N. Benson Rd, Fairfield, CT 06824, USAHerein, we report the design and characterization of guanosine-containing self-assembling nucleopeptides that form nanosheets and nanofibers. Through spectroscopy and microscopy analysis, we propose that the peptide component of the nucleopeptide drives the assembly into β-sheet structures with hydrogen-bonded guanosine forming additional secondary structures cooperatively within the peptide framework. Interestingly, the distinct supramolecular morphologies are driven not by metal cation responsiveness common to guanine-based materials, but by the C-terminal peptide chemistry. This work highlights the structural diversity of self-assembling nucleopeptides and will help advance the development of applications for these supramolecular guanosine-containing nucleopeptides.https://www.mdpi.com/1420-3049/25/23/5493nucleopeptideself-assemblyguanosineG-quartet |
| spellingShingle | Katherine Boback Katherine Bacchi Sarah O’Neill Samantha Brown Jovelt Dorsainvil Jillian E. Smith-Carpenter Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides Molecules nucleopeptide self-assembly guanosine G-quartet |
| title | Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides |
| title_full | Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides |
| title_fullStr | Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides |
| title_full_unstemmed | Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides |
| title_short | Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides |
| title_sort | impact of c terminal chemistry on self assembled morphology of guanosine containing nucleopeptides |
| topic | nucleopeptide self-assembly guanosine G-quartet |
| url | https://www.mdpi.com/1420-3049/25/23/5493 |
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