Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drug
Cancer metastasis is a dynamic process during which cancer cells separate from a primary tumor, migrate through the vessel wall into the bloodstream, and extravasate at distant sites to form secondary colonies. During this process, circulating tumor cells are subjected to shear stress forces from bl...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-11-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2017.1416076 |
| _version_ | 1797684299786354688 |
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| author | Annachiara Mitrugno Joanna L. Sylman Rachel A. Rigg Samuel Tassi Yunga Joseph J. Shatzel Craig D. Williams Owen J.T. McCarty |
| author_facet | Annachiara Mitrugno Joanna L. Sylman Rachel A. Rigg Samuel Tassi Yunga Joseph J. Shatzel Craig D. Williams Owen J.T. McCarty |
| author_sort | Annachiara Mitrugno |
| collection | DOAJ |
| description | Cancer metastasis is a dynamic process during which cancer cells separate from a primary tumor, migrate through the vessel wall into the bloodstream, and extravasate at distant sites to form secondary colonies. During this process, circulating tumor cells are subjected to shear stress forces from blood flow, and in contact with plasma proteins and blood cells of the immune and hemostatic system, including platelets. Many studies have shown an association between high platelet count and cancer metastasis, suggesting that platelets may play an occult role in tumorigenesis. This mini-review summarizes recent and emerging discoveries of mechanisms by which cancer cells activate platelets and the role of activated platelets in promoting tumor growth and metastasis. Moreover, the review discusses how aspirin has the potential for being clinically used as an adjuvant in cancer therapy. |
| first_indexed | 2024-03-12T00:27:34Z |
| format | Article |
| id | doaj.art-da9c2bcdc14441018ae10a78d4bf08f7 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:27:34Z |
| publishDate | 2018-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-da9c2bcdc14441018ae10a78d4bf08f72023-09-15T10:31:59ZengTaylor & Francis GroupPlatelets0953-71041369-16352018-11-0129877377810.1080/09537104.2017.14160761416076Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drugAnnachiara Mitrugno0Joanna L. Sylman1Rachel A. Rigg2Samuel Tassi Yunga3Joseph J. Shatzel4Craig D. Williams5Owen J.T. McCarty6Department of Biomedical EngineeringDepartment of Biomedical EngineeringDepartment of Biomedical EngineeringCancer Early Detection & Advanced Research CenterDivision of Hematology & Medical OncologyOregon State UniversityDepartment of Biomedical EngineeringCancer metastasis is a dynamic process during which cancer cells separate from a primary tumor, migrate through the vessel wall into the bloodstream, and extravasate at distant sites to form secondary colonies. During this process, circulating tumor cells are subjected to shear stress forces from blood flow, and in contact with plasma proteins and blood cells of the immune and hemostatic system, including platelets. Many studies have shown an association between high platelet count and cancer metastasis, suggesting that platelets may play an occult role in tumorigenesis. This mini-review summarizes recent and emerging discoveries of mechanisms by which cancer cells activate platelets and the role of activated platelets in promoting tumor growth and metastasis. Moreover, the review discusses how aspirin has the potential for being clinically used as an adjuvant in cancer therapy.http://dx.doi.org/10.1080/09537104.2017.1416076plateletscanceraspirin |
| spellingShingle | Annachiara Mitrugno Joanna L. Sylman Rachel A. Rigg Samuel Tassi Yunga Joseph J. Shatzel Craig D. Williams Owen J.T. McCarty Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drug Platelets platelets cancer aspirin |
| title | Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drug |
| title_full | Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drug |
| title_fullStr | Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drug |
| title_full_unstemmed | Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drug |
| title_short | Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drug |
| title_sort | carpe low dose aspirin the new anti cancer face of an old anti platelet drug |
| topic | platelets cancer aspirin |
| url | http://dx.doi.org/10.1080/09537104.2017.1416076 |
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