Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders
As the main secondary messengers, cyclic AMP (cAMP) and Ca2+ trigger intracellular signal transduction cascade and, in turn, regulate many aspects of cellular function in developing and mature neurons. The group I adenylyl cyclase (ADCY, also known as AC) isoforms, including ADCY1, 3, and 8 (also kn...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.949384/full |
| _version_ | 1828145701490524160 |
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| author | Jiao Chen Qi Ding Lulu An Hongbing Wang |
| author_facet | Jiao Chen Qi Ding Lulu An Hongbing Wang |
| author_sort | Jiao Chen |
| collection | DOAJ |
| description | As the main secondary messengers, cyclic AMP (cAMP) and Ca2+ trigger intracellular signal transduction cascade and, in turn, regulate many aspects of cellular function in developing and mature neurons. The group I adenylyl cyclase (ADCY, also known as AC) isoforms, including ADCY1, 3, and 8 (also known as AC1, AC3, and AC8), are stimulated by Ca2+ and thus functionally positioned to integrate cAMP and Ca2+ signaling. Emerging lines of evidence have suggested the association of the Ca2+-stimulated ADCYs with bipolar disorder, schizophrenia, major depressive disorder, post-traumatic stress disorder, and autism. In this review, we discuss the molecular and cellular features as well as the physiological functions of ADCY1, 3, and 8. We further discuss the recent therapeutic development to target the Ca2+-stimulated ADCYs for potential treatments of psychiatric and neurodevelopmental disorders. |
| first_indexed | 2024-04-11T20:35:33Z |
| format | Article |
| id | doaj.art-da9cd9c6fc9e416880fd6ecec4de7f7d |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T20:35:33Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-da9cd9c6fc9e416880fd6ecec4de7f7d2022-12-22T04:04:23ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.949384949384Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disordersJiao ChenQi DingLulu AnHongbing WangAs the main secondary messengers, cyclic AMP (cAMP) and Ca2+ trigger intracellular signal transduction cascade and, in turn, regulate many aspects of cellular function in developing and mature neurons. The group I adenylyl cyclase (ADCY, also known as AC) isoforms, including ADCY1, 3, and 8 (also known as AC1, AC3, and AC8), are stimulated by Ca2+ and thus functionally positioned to integrate cAMP and Ca2+ signaling. Emerging lines of evidence have suggested the association of the Ca2+-stimulated ADCYs with bipolar disorder, schizophrenia, major depressive disorder, post-traumatic stress disorder, and autism. In this review, we discuss the molecular and cellular features as well as the physiological functions of ADCY1, 3, and 8. We further discuss the recent therapeutic development to target the Ca2+-stimulated ADCYs for potential treatments of psychiatric and neurodevelopmental disorders.https://www.frontiersin.org/articles/10.3389/fphar.2022.949384/fullautismCa2+-stimulated adenylyl cyclasebipolar disorderschizophreniamajor depressive disorderpost-traumatic stress disorder |
| spellingShingle | Jiao Chen Qi Ding Lulu An Hongbing Wang Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders Frontiers in Pharmacology autism Ca2+-stimulated adenylyl cyclase bipolar disorder schizophrenia major depressive disorder post-traumatic stress disorder |
| title | Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders |
| title_full | Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders |
| title_fullStr | Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders |
| title_full_unstemmed | Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders |
| title_short | Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders |
| title_sort | ca2 stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders |
| topic | autism Ca2+-stimulated adenylyl cyclase bipolar disorder schizophrenia major depressive disorder post-traumatic stress disorder |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.949384/full |
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