Systemic inflammation response index predicts 3-month outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis
IntroductionA crucial aspect of stroke progression is the inflammatory response. As novel inflammatory and prognostic markers, the systemic immune inflammation index (SII) and the systemic inflammation response index (SIRI) have recently been studied. The objective of our study was to evaluate the p...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1095668/full |
| _version_ | 1811169454072004608 |
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| author | Min Chu Yunhe Luo Daosheng Wang Yang Liu Delong Wang Yong Wang Jing Zhao |
| author_facet | Min Chu Yunhe Luo Daosheng Wang Yang Liu Delong Wang Yong Wang Jing Zhao |
| author_sort | Min Chu |
| collection | DOAJ |
| description | IntroductionA crucial aspect of stroke progression is the inflammatory response. As novel inflammatory and prognostic markers, the systemic immune inflammation index (SII) and the systemic inflammation response index (SIRI) have recently been studied. The objective of our study was to evaluate the prognostic value of SII and SIRI in mild acute ischemic stroke (AIS) patients following intravenous thrombolysis (IVT).MethodsOur study screened the clinical data of patients with mild AIS admitted to the Minhang Hospital of Fudan University for retrospective analysis. The SIRI and SII were examined by the emergency laboratory before IVT. Functional outcome was evaluated 3 months after the onset of stroke using the modified Rankin Scale (mRS). mRS ≥ 2 was defined as an unfavorable outcome. The relationship between SIRI and SII and the 3-month prognosis was determined using both univariate and multivariate analysis. Receiver operating characteristic curve was performed to evaluate the predictive value of SIRI for AIS prognosis.ResultsA total of 240 patients were included in this study. Both SIRI and SII were higher in the unfavorable outcome group than in the favorable outcome group [1.28 (0.70–1.88) vs. 0.79 (0.51–1.08), P < 0.001 and 531.93 (377.55–797.12) vs. 397.23 (263.32–577.65), P < 0.001]. Multivariate logistic regression analyses showed that SIRI was significantly associated with 3-month unfavorable outcome of mild AIS patients [odds ratio (OR) = 2.938, 95% confidence interval (CI) = 1.805–4.782, P < 0.001], conversely, SII had no prognostic value. When SIRI combined with the established clinical factors, the area under the curve (AUC) showed a significant improvement (0.773 vs. 0.683, P for comparison = 0.0017).ConclusionsHigher SIRI could be valuable in predicting poor clinical outcomes for patients with mild AIS following IVT. |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T16:42:39Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-da9d984d899f405b93f37991b8a1598a2023-02-08T06:23:35ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-02-011410.3389/fneur.2023.10956681095668Systemic inflammation response index predicts 3-month outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysisMin Chu0Yunhe Luo1Daosheng Wang2Yang Liu3Delong Wang4Yong Wang5Jing Zhao6Department of Neurology, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Minhang Hospital, Fudan University, Shanghai, ChinaIntroductionA crucial aspect of stroke progression is the inflammatory response. As novel inflammatory and prognostic markers, the systemic immune inflammation index (SII) and the systemic inflammation response index (SIRI) have recently been studied. The objective of our study was to evaluate the prognostic value of SII and SIRI in mild acute ischemic stroke (AIS) patients following intravenous thrombolysis (IVT).MethodsOur study screened the clinical data of patients with mild AIS admitted to the Minhang Hospital of Fudan University for retrospective analysis. The SIRI and SII were examined by the emergency laboratory before IVT. Functional outcome was evaluated 3 months after the onset of stroke using the modified Rankin Scale (mRS). mRS ≥ 2 was defined as an unfavorable outcome. The relationship between SIRI and SII and the 3-month prognosis was determined using both univariate and multivariate analysis. Receiver operating characteristic curve was performed to evaluate the predictive value of SIRI for AIS prognosis.ResultsA total of 240 patients were included in this study. Both SIRI and SII were higher in the unfavorable outcome group than in the favorable outcome group [1.28 (0.70–1.88) vs. 0.79 (0.51–1.08), P < 0.001 and 531.93 (377.55–797.12) vs. 397.23 (263.32–577.65), P < 0.001]. Multivariate logistic regression analyses showed that SIRI was significantly associated with 3-month unfavorable outcome of mild AIS patients [odds ratio (OR) = 2.938, 95% confidence interval (CI) = 1.805–4.782, P < 0.001], conversely, SII had no prognostic value. When SIRI combined with the established clinical factors, the area under the curve (AUC) showed a significant improvement (0.773 vs. 0.683, P for comparison = 0.0017).ConclusionsHigher SIRI could be valuable in predicting poor clinical outcomes for patients with mild AIS following IVT.https://www.frontiersin.org/articles/10.3389/fneur.2023.1095668/fullsystemic immune inflammation indexsystemic inflammation response indexmild acute ischemic strokeintravenous thrombolysis3-month outcome |
| spellingShingle | Min Chu Yunhe Luo Daosheng Wang Yang Liu Delong Wang Yong Wang Jing Zhao Systemic inflammation response index predicts 3-month outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis Frontiers in Neurology systemic immune inflammation index systemic inflammation response index mild acute ischemic stroke intravenous thrombolysis 3-month outcome |
| title | Systemic inflammation response index predicts 3-month outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis |
| title_full | Systemic inflammation response index predicts 3-month outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis |
| title_fullStr | Systemic inflammation response index predicts 3-month outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis |
| title_full_unstemmed | Systemic inflammation response index predicts 3-month outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis |
| title_short | Systemic inflammation response index predicts 3-month outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis |
| title_sort | systemic inflammation response index predicts 3 month outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis |
| topic | systemic immune inflammation index systemic inflammation response index mild acute ischemic stroke intravenous thrombolysis 3-month outcome |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1095668/full |
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